Pharmacokinetic parameters of ondansetron in rats after oral solution and transdermal invasomes gel: A comparison study

Salih, Omar Saeb; Al-Akkam, Entidhar Jasim

doi:10.51847/hs5a27ei6o

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…The drug's maximum plasma concentration (Cmax) and time to Cmax (Tmax) were determined. AUC0-72 is the area under the plasma concentration-time curve from 0 to 72 hours [10,11].…”

Section: Detection Of Pocz In Plasma Sample By Hplcmentioning

confidence: 99%

Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug

Abdulqader¹,

Rajab²

2023

J Adv Pharm Educ Res

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“…The drug's maximum plasma concentration (Cmax) and time to Cmax (Tmax) were determined. AUC0-72 is the area under the plasma concentration-time curve from 0 to 72 hours [10,11].…”

Section: Detection Of Pocz In Plasma Sample By Hplcmentioning

confidence: 99%

Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug

Abdulqader¹,

Rajab²

2023

J Adv Pharm Educ Res

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Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine

Dwivedi,

Bala,

Madaan

et al. 2024

Journal of Complementary and Integrative Medicine

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Health care workers have faced a significant challenge because of the rise in cancer incidence around the world during the past 10 years. Among various forms of malignancy skin cancer is most common, so there is need for the creation of an efficient and safe skin cancer treatment that may offer targeted and site-specific tumor penetration, and reduce unintended systemic toxicity. Nanocarriers have thus been employed to get around the issues with traditional anti-cancer drug delivery methods. Invasomes are lipid-based nanovesicles having small amounts of terpenes and ethanol or a mixture of terpenes and penetrate the skin more effectively. Compared to other lipid nanocarriers, invasomes penetrate the skin at a substantially faster rate. Invasomes possess a number of advantages, including improved drug effectiveness, higher compliance, patient convenience, advanced design, multifunctionality, enhanced targeting capabilities, non-invasive delivery methods, potential for combination therapies, and ability to overcome biological barriers,. These attributes position invasomes as a promising and innovative platform for the future of cancer treatment. The current review provides insights into invasomes, with a fresh organizational scheme and incorporates the most recent cancer research, including their composition, historical development and methods of preparation, the penetration mechanism involving effect of various formulation variables and analysis of anticancer mechanism and the application of invasomes.

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Pharmacokinetic Study of Oral Disulfiram Suspension and Topical Transdermal Nano-Invasomes Gel in Wistar Rats

Al-Zheery,

Kassab

2024

Al-Rafidain J Med Sci

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Background: Disulfiram (DSF), an FDA-approved pharmaceutical for the management of alcoholism, has demonstrated its efficacy against several kinds of cancer. DSF has limited solubility, a fast metabolism, a short duration of action, and instability in physiological environments, mostly caused by rapid degradation in the acidic gastric environment. Objective: A transdermal gel containing disulfiram, which was loaded into invasomes, was developed to improve the stability of DSF and enable its effective distribution to tumor tissues. Methods: This study included 72 Wistar rats weighing 200±35 g, which were separated into two groups, each of which included 12 animals. Rats were orally provided a dose of 5 mg of pure DSF suspension via oral gavage, and DSF nano-invasomal transdermal gel was then applied to their skin. DSF is determined in rats' plasma by reverse-phase high-performance liquid chromatography (RP-HPLC). Results: The results showed that the maximum effect (Cmax, Tmax, and AUC0-72) were (Cmax=57.3±0.2, Tmax=3.6±0.01 and 562±3. 3ng.h/ml) for oral and (Cmax=138±0.4, Tmax=5.5±0.01 and 2819±6.6 ng. h/ml) for transdermal routes, respectively. Results showed that the time and concentration needed to achieve the maximum effect (Cmax and Tmax) were significantly different between DSF-oral suspension and transdermal invasomal gel (p<0.05). The relative bioavailability for the transdermal route was five times that of the oral route after a single dose administered for 72 hours. Conclusions: The nano-invasomal transdermal gel filled with DSF demonstrated a more convenient way of administering DSF compared to the oral route.

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Pharmacokinetic parameters of ondansetron in rats after oral solution and transdermal invasomes gel: A comparison study

Cited by 4 publications

References 17 publications

Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug

Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug

Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine

Pharmacokinetic Study of Oral Disulfiram Suspension and Topical Transdermal Nano-Invasomes Gel in Wistar Rats

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