Pharmacokinetic Parameters of Ciprofloxacin in Bangladeshi Volunteers: A Preliminary Evaluation

Abstract

The present study has attempted to establish a High-performance liquid chromatography (HPLC) method to determine ciprofloxacin in plasma, in order to evaluate the bioavailability of ciprofloxacin. In this study, initially 8 (eight) Bangladeshi Bangalee healthy male volunteers and 7 (seven) Bangladeshi Tribal healthy male volunteers received 500 mg tablet of pioneer brand of ciprofloxacin in oral route. Blood samples were collected at 0, 30, 60, 120, 180, 360, 540 and 720 minutes after drug administration. After 1 week of washout period, same volunteers of two groups received 200 mg injection of pioneer brand of ciprofloxacin in intravenous route. HPLC with ultraviolet detection was used to quantify plasma ciprofloxacin concentrations.

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study

“…The pharmacokinetic status of Bangladeshi population is still not very clearly understood, though couple of studies revealed that orally administered medicines achieve adequate concentration to demonstrate desired pharmacological effects (Chowdhury et al, 2010;Chowdhury et al, 2011;Chowdhury et al, 2014). The present study was not designed to ascertain or clarify the correlation of kinetics with dynamics.…”

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

“…Though some initiative and effort was made towards understanding the pharmacokinetics of antimicrobials in Bangladeshi children 22 and adult population [23][24] , very little development has been achieved. There were different challenges like selection of volunteers, laboratory facilities, establishment of laboratory methods and hospitalization of volunteers, for which this type of pharmacokinetic study could not be conducted before in this region.…”