Pharmacokinetic Modifications and Drug-Drug Interactions in Clinical Monitoring of the Elderly: A Short Review

Quintas, Luis Eduardo M.; Gram, Karla Regina S.

doi:10.4172/2153-2435.1000141

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…A method needs to separate the desired components satisfactorily, they need to generate the required result and they must be reproducible and robust so that they can be used time after time without problems. The selection of suitable HPLC conditions to achieve a desired separation is often both confusing and time consuming in order to have an efficient method development process, the following three things to keep in mind [48].…”

Section: Effective Hplc Methods Developmentmentioning

confidence: 99%

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Jena¹

2012

Pharm Anal Acta

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The analytical technique of High Performance Liquid Chromatography (HPLC) is used extensively thought the pharmaceutical industry. It allows simultaneously both qualitative and quantitative information of a drug. It is used to provide information on the composition of drug related samples. The information obtained may be qualitative, indicating what compounds are present in the sample. The information obtained may be qualitative, providing the actual amount of compounds in the sample. HPLC is used in all the different stages in the creation of new drug discoveries and also used routinely in the drug manufacturing process. The HPLC techniques is highly accessible to the author's knowledge this review represents the most exhaust description of instrumentation, method development, recent advancement, area of application. This article reviews the most recent advances in sample preparation, separation and the mass spectrometric aspects of high-throughput for method development.

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Section: Effective Hplc Methods Developmentmentioning

confidence: 99%

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Jena¹

2012

Pharm Anal Acta

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“…In this the carrier molecule is a drug which helps in overcoming side effects caused by the parent active drug, improving site specificity etc. The best example of mixed drug is Paracodol, a generic pain killer which is thecombination of paracetamol and codeine [25].…”

Section: Prodrug: Categorizationmentioning

confidence: 99%

Cutting Edge Approach on Prodrug: Contrivance for Target Drug Delivery

Varsha¹,

Rao²,

Rao³

2011

JBB

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Drug administration procedures are very much vital and are considered to be the prime-most criteria during the drug design and its appliance. Scrutinizing this, drugs are designed in such a way, bringing some change in their persona like bioavailability and bioequivalence. One such approach called prodrug, first started in 1950's is still a fertile area of research because of it's insist persona. Prodrugs are the shrouded drugs which are one or two chemical or enzymatic steps away from the active parent drug. Present review delineates about the prodrug action, types of prodrugs, new prodrug therapies, nanotech allied prodrugs.

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Do FSH/LH ratio and gonadal hormone levels predict clinical improvement in postmenopausal schizophrenia women?

González-Rodríguez

Bernardo

Penadés

et al. 2017

Arch Womens Ment Health

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Menopause is a process characterized by a decline in estrogen levels and is therefore a period of biological vulnerability for psychotic relapse in women with schizophrenia. Our goal was to correlate not only gonadal hormone levels but also follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels with improvement in specific clinical symptoms. Thirty-seven acutely ill postmenopausal schizophrenia women with a newly initiated, clinically determined change in antipsychotic medication participated in a 12-week prospective observational outcome study. Scales used were the PANSS scale for psychotic symptoms, the PSP for functioning, and CGI for global clinical impression. Circulating FSH, LH, estradiol, progesterone, and testosterone serum levels were determined by chemiluminescent immunoassay. Partial correlational analyses were performed along with a Bonferroni significance correction (p < 0.0007). After adjustment for confounding factors, the FSH/LH ratio correlated positively with mean changes in PANSS positive scores, and there was a correlation with worsening of CGI total and cognitive scores. Testosterone was also positively associated with improvement in PANSS positive scores. However, after correction for multiple testing, the initial correlations were no longer statistically significant. In summary, while the hormone assays we did in this small sample did not prove to be significantly linked to clinical improvement in any of the schizophrenia symptom domains, we recommend further investigation of pituitary, adrenal, and gonadal hormone ratios as potential markers of clinical improvement in this population.

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Pharmacokinetic Modifications and Drug-Drug Interactions in Clinical Monitoring of the Elderly: A Short Review

Cited by 5 publications

References 32 publications

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

HPLC: Highly Accessible Instrument in Pharmaceutical Industry for Effective Method Development

Cutting Edge Approach on Prodrug: Contrivance for Target Drug Delivery

Do FSH/LH ratio and gonadal hormone levels predict clinical improvement in postmenopausal schizophrenia women?

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