Pharmacokinetic Model and Arterial Input Function Selection in Dynamic Contrast Enhanced-MRI in Head and Neck Cancers

Assili, Sanam; Kazerooni, Anahita Fathi; Rad, Hamidreza Saligheh

doi:10.5812/iranjradiol.21291

Cited by 1 publication

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“…Dynamic contrast enhanced MRI, such as diffusion MRI, provides images with high spatial resolution and facilitates the evaluation of tumor vasculature or response to antiangiogenic therapies. Nevertheless, it requires the use of intravenous contrast and relatively complicated post-processing of acquired images [7] [19] [20]. The helpfulness of diffusion MRI in the evaluation of stroke led to its exploration as an early marker of tumor response to therapy, and over the last 22 years, similar early diffusion changes have been demonstrated to occur in both preclinical and clinical settings.…”

Section: Brain Tumorsmentioning

confidence: 99%

Diffusion and Perfusion Magnetic Resonance Imaging:Fundamentals and Advances

Assili

2016

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Over the past few decades, magnetic resonance imaging has been utilized as a powerful imaging modality to evaluate the structure and function of various organs in the human body, such as the brain. Additionally, diffusion and perfusion MR imaging have been increasingly used in neurovascular clinical applications. In diffusion weighted magnetic resonance imaging, the mobility of water molecules is explored in order to obtain information about the microscopic behaviour of the tissues. In contrast, perfusion weighted imaging uses tracers to exploit hemodynamic status, which enables researchers and clinicians to consider this imaging modality as an early biomarker of certain brain diseases. In this review, the fundamentals of physics for diffusion and perfusion MR imaging -both of which are highly sensitive to microenvironmental alterations at the cellular level -as well as their application in the treatment of aging, Alzheimer's disease, brain tumors and cerebral ischemic injury were discussed.

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Section: Brain Tumorsmentioning

confidence: 99%