Pharmacokinetic interaction study of combining imatinib with dasatinib in rats by UPLC–MS/MS

Zhou, Yunfang; Wang, Shuanghu; Ding, Tao; Wu, Mei; Geng, Peiwu; Zhang, Qingwei; Ma, Jianshe

doi:10.3109/03639045.2015.1004182

Cited by 6 publications

(4 citation statements)

References 35 publications

(29 reference statements)

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“…There are many receptor tyrosine kinases already on the market, such as imatinib, erlotinib, gefitinib, and sunitinib [16–18]. Imatinib is a cytochrome of CYP3A4 and CYP2C8 substrate, which can markedly increase plasma concentrations of the CYP3A4 substrate and reduce hepatic CYP3A4 activity in humans [19].…”

Section: Discussionmentioning

confidence: 99%

Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Wei

Wang

Chen

et al. 2017

BioMed Research International

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The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with anlotinib (treatment group) or saline (control group) by oral administration, probe drugs phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam were administered to rats by oral administration. Blood samples were obtained at a series of time-points and the concentrations of five probe drugs in plasma were determined by a UHPLC-MS/MS method. The results showed that treatment with anlotinib had no significant effect on rat CYP1A2, CYP2D2, and CYP2C6. However, anlotinib had a significant inductive effect on CYP2D1 and CYP3A1/2. Therefore, caution is needed during the concomitant use of anlotinib with other drugs metabolized by CYP2D1 and CYP3A1/2 because of potential drug-anlotinib interactions.

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Section: Discussionmentioning

confidence: 99%

Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Wei

Wang

Chen

et al. 2017

BioMed Research International

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“…Conversely, several marketed polyherbal formulations are available without labeled claim on relative percentage composition of individual curcuminoids. 12 Several methods were reported for the estimation of curcumin in different pharmaceutical and herbal formulations by using UV, 13 HPLC, 14 UPLC, 15 HPTLC, 16 FT-IR 17 and others hyphenated methods. 18,19 However, these techniques are not suitable for analyzing compounds in combinations of polyherbal formulations like Ayurvedic or Chinese medicinal products, since they contain more than one herb.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of UV-Spectrophotometric method for the Estimation of Curcumin in Standardised Polyherbal Formulations

Singh¹,

Avupati²

2017

JYP

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Objective: We aimed to develop and validate a simple UV-spectrophotometric method relates to the estimation of curcumin in standardised polyherbal formulations. Methods: Pure curcumin was received as generous gift sample from Andhra University, India, all solvents and reagents of analytical reagent (AR) grade were procured from local suppliers and readily used for the method development. The method validation parameters were evaluated as per International Conference on Harmonization (ICH) guidelines. Further, this method was applied for the assay of curcumin in marketed product Live-well™, CUMIN (standardised turmeric extract (STE) fortified with standardised black pepper (SBE) extract) capsules using UV-spectrophotometric method. Results and Discussion: It was confirmed from the results of method validation characteristics such as specificity, linearity, range, precision, accuracy, and robustness were keeping within the limits of acceptance criteria defined under ICH guidelines, 76.0560% of curcumin was estimated to be present in each Live-well™, CUMIN capsule containing a minimum 95% of the total curcuminoids (label claimed). Conclusion:In summary, our method was found to be reliable in detecting the unknown percentage of curcumin in Live-well™, CUMIN capsule formulation. Also, the method was proved to be specific, linear, precise, accurate and robust to use for routine analysis of polyherbal formulations containing curcumin as their principal component in the extracts.Key words: UV-spectrophotometric method, Curcumin, ICH Guidelines, Live-well™, CUMIN. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…Since the properties of intestinal mucus cannot be tuned in vivo , we assessed the effect of particle size and concentration. To study the effect of particle size, we administered (i) DAS nanoparticles with D h of 200 nm and (ii) unprocessed DAS particles with a D h of 1.2 μm (similar to pure curcumin nanoparticles of intermediate size), both at a dose of 10 mg kg −1 , which is clinically relevant [81,82]. To study the effect of particle concentration, we administered two different doses (10 and 15 mg kg −1 ) of pure DAS nanoparticles (D h = 200 nm).…”

Section: Resultsmentioning

confidence: 99%

An experimental and theoretical approach to understand the interaction between particles and mucosal tissues

Sverdlov

Cohen

Sosnik

2022

Preprint

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Nanonization of poorly water-soluble drugs has shown great potential in improving their oral bioavailability by enhancing the dissolution rate and saturation solubility. Moreover, due to particle size reduction and larger surface area, the number of contact points with the gastrointestinal mucus favors adhesion. Similar phenomena could be anticipated when nano-pollutants come into direct contact with mucosal tissues. However, the fundamental features that govern the interaction of particles with mucus have not been investigated in a systematic and rational way before. In this work, we synthesize mucin hydrogels of different pore sizes with rheological properties that closely mimic the properties of freshly extracted porcine mucin. By using fluorescent pure curcumin particles, we characterize the effect of particle size (hydrodynamic diameter of 200 nm, and 1.2 and 1.3 μm), concentration (18, 35, and 71 μg mL−1), and hydrogel crosslinking density (which is directly related to the stiffness and governs the average pore size) on the diffusion-driven particle penetration in vitro. Next, we derive a phenomenological model that describes the physics behind the diffusion-derived penetration of particles into the mucin network and considers the contributions of the particle size, the particle concentration, and the crosslinking density of the mucin hydrogel. Finally, we challenge our experimental-theoretical approach by preliminarily assessing the oral pharmacokinetics of an anti-cancer model drug, namely dasatinib, in pristine and nanonized forms and two clinically relevant doses in rats. For of a dose of 10 mg kg−1, drug nanonization leads to a significant ~8- and ~21-fold increase of the drug oral bioavailability and half-life, respectively, with respect to the unprocessed micron-sized drug. When the drug dose of pure drug nanoparticles (which is directly related to the local concentration of the drug in the gastrointestinal tract) was increased to 15 mg mL−1, the oral bioavailability increased though not significantly, suggesting the saturation of the penetration sites in the mucus, as demonstrated by the in vitro model. Our overall results reveal the potential of this experimental-theoretical approach, shed light on the interaction of particulate matter and mucosal tissues, and pave the way for the development of tools that enable a more rational design of nano-drug delivery systems for mucosal administration and the assessment of risk factors related to the exposure of mucosal tissues to nano-pollutants.

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Pharmacokinetic interaction study of combining imatinib with dasatinib in rats by UPLC–MS/MS

Cited by 6 publications

References 35 publications

Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Development and Validation of UV-Spectrophotometric method for the Estimation of Curcumin in Standardised Polyherbal Formulations

An experimental and theoretical approach to understand the interaction between particles and mucosal tissues

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