Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences

Oga, Enoche Florence; Sekine, Satoshi; Shitara, Yoshihisa; Horie, Toshiharu

doi:10.1007/s13318-015-0296-z

Cited by 53 publications

(40 citation statements)

References 144 publications

(44 reference statements)

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“…16 Also, there are indications that the botanicals ginkgo (Ginkgo biloba), garlic (Allium sativum) and ginseng (Panax ginseng) may interact with anticoagulants. 17,18 In a follow up study, the available data can be further analysed to see if potentially harmful combinations are reported.…”

Section: Papermentioning

confidence: 99%

Consumption of plant food supplements in the Netherlands

et al. 2018

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The use of food supplements containing herbs or other botanical ingredients (plant food supplements, PFS) is on the rise. In some cases, PFS can contain compounds that are toxic and may pose a health risk. To assess the potential health risks, information on the consumption of PFS is required, however, this was lacking for the Netherlands. In the current study, the consumption of PFS was investigated for several subgroups in the Dutch population, including children. Data from the Dutch National Food Consumption Surveys were used to get a first impression on the consumption of PFS. To obtain more detailed information, a specific PFS consumption survey was performed using online questionnaires. First, a screening survey was performed among a representative sample of 75 100 adults and children of the Dutch population, followed by a main survey among 739 selected PFS users in eight different age and gender subgroups. The prevalence of PFS users in the Dutch population was approximately 10% for men, 17% for women and 13% for children. A wide variety of PFS was used, with around 600 different PFS reported, containing 345 different botanicals. The most frequently used botanicals were echinacea (Echinacea purpurea), ginkgo (Ginkgo biloba), cranberry (Vaccinium macrocarpon), ginseng (Panax ginseng) and algae (such as species belonging to the genus Spirulina or Chlorella). Because PFS are widely used in the Dutch population, it is important to evaluate the potential risks associated with PFS consumption in the Netherlands, including potential herb-drug interactions. The data collected in this study are of great value to assess these risks.

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Section: Papermentioning

confidence: 99%

Consumption of plant food supplements in the Netherlands

et al. 2018

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“…Whether concurrent use of conventional drugs and herbs can lead to adverse reactions is controversial (Ma & Ma, 2016;Oga, Sekine, Shitara, & Horie, 2016). The use of herbal medicine alone or in combination with RD-related medications was not included in the final multiple regression model.…”

Section: Incidence Risk Of Lea In Each Rdmentioning

confidence: 99%

Liver enzyme abnormalities of inpatients with rheumatic diseases: A 10‐year retrospective study in a Korean medicine hospital

Lee

Kang

et al. 2018

Phytotherapy Research

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Herbal medicines have been used as a treatment option for rheumatic disease (RD), but they often produce liver enzyme abnormality. This study examines the incidence of herb-induced liver injury (HILI) and the relationship between risk factors and liver enzyme abnormality (LEA) in inpatients with RD. HILI was analyzed using the Roussel Uclaf causality assessment method liver injury criteria and causality assessment. Multivariable analysis was performed to assess the relationship between patient characteristics and LEA in RD. The features of LEA were also examined in each RD. Among 352 patients included in this study, 105 patients showed LEA on admission, of which 6 had fulfilled the Roussel Uclaf causality assessment method criteria. The incidence risks of LEA and HILI were 12.55% and 0.58%, respectively. Multivariable analysis showed that LEA on admission and occasional use of alcohol could be risk factors for LEA on follow-up. In an additional analysis with each RD, all rheumatoid arthritis patients with LEA were taking nonsteroidal anti-inflammatory drugs, steroids, and disease-modifying antirheumatic drugs, and 4 out of 5 gout patients with LEA were taking steroids. The use of herbal medicine in RD is relatively safe. However, regular monitoring of liver enzyme tests and examination of alcohol consumption are required.

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“…Plants are widely used as a first line remedy for the infection in malaria-endemic areas, with reports of up to 80 % of the local population in some developing countries dependent on these as their primary source of healthcare [1]. Willcox and Bodeker [2] prepared a database with 1277 plant species from 160 families being used to treat malaria or fever.…”

Section: The Disease 'Malaria'mentioning

confidence: 99%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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Malaria is a potentially lethal disease caused by species of the plasmodium parasite. Despite the advances in the interventions for its control and approaches to manage fatality, morbidity and mortality rates associated with malaria are still high. At present, artemisinin-based combination therapy is the first line of treatment. However, there is the need to explore newer approaches as reduced effectiveness and multi-drug resistance (even to artemisinin) has been reported in some regions and is expected to widen in scope. Phytomedicines have shown promise for the management of this debilitating disease and there are abundant resources in most of the areas where this disease is endemic. This report would systematically review the literature, emphasizing the challenges encountered in the control of malaria, active phytochemicals currently utilised in the management, drug delivery approaches as well as the nanotechnology-based systems that could be exploited in its treatment. These phytomedicines, either delivered conventionally or via the use of advanced delivery systems may suggest new strategies towards the better management of malaria.

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Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences

Cited by 53 publications

References 144 publications

Consumption of plant food supplements in the Netherlands

Consumption of plant food supplements in the Netherlands

Liver enzyme abnormalities of inpatients with rheumatic diseases: A 10‐year retrospective study in a Korean medicine hospital

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

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