Pharmacokinetic herb–drug interaction of Xuesaitong dispersible tablet and aspirin after oral administration in blood stasis model rats

Dai, Guoliang; Jiang, Zhitao; Bai, Yong; Zhang, Qian; Zhu, Lei; Bai, Xiaohui; Ju, Wenzheng; Pan, Ronghua

doi:10.1016/j.phymed.2017.01.010

Cited by 16 publications

(4 citation statements)

References 20 publications

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“…In most instances, in vitro and animal studies are conducted to evaluate the effect of herbal extracts and phytochemical constituents on pharmacokinetic and pharmacodynamic properties of probe drugs [16][17][18][19][20][21][22]. However, preclinical investigations often do not correlate with findings in human subjects [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Critical evaluation of causality assessment of herb–drug interactions in patients

Awortwe

Makiwane

Reuter

et al. 2018

Brit J Clinical Pharma

114

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The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to herb-drug interactions (HDI) in patients taking herbs and prescribed medications based on published evidence. Electronic databases of PubMed, the Cochrane Library, Medline and Scopus were searched for randomized or nonrandomized clinical studies, case-control and case reports of HDI. The data were extracted and the causal relationship of ADRs as consequences of HDI assessed using Horn's drug interaction probability scale or Roussel Uclaf Causality Assessment Method scoring systems. The mechanism of interaction was ascertained using Stockley's herbal medicine interaction companion. Forty-nine case reports and two observational studies with 15 cases of ADRs were recorded. The majority of the patients were diagnosed with cardiovascular diseases (30.60%), cancer (22.45%) and renal transplants (16.32%) receiving mostly warfarin, alkylating agents and cyclosporine, respectively. HDI occurred in patients resulting in clinical ADRs with different severity. Patients may poorly respond to therapeutic agents or develop toxicity due to severe HDI, which in either scenario may increase the cost of treatment and/or lead to or prolong patient hospitalization. It is warranted to increase patient awareness of the potential interaction between herbs and prescribed medicines and their consequences to curb HDI as a potential health problem.

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Section: Introductionmentioning

confidence: 99%

Critical evaluation of causality assessment of herb–drug interactions in patients

Awortwe

Makiwane

Reuter

et al. 2018

Brit J Clinical Pharma

114

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“…Overexpression of SGPL1 promoted HHL-5 hepatocyte apoptosis, which revealed that Rg1 served an anti-apoptotic effect by downregulating SGPL1. Furthermore, Rg1 is one of the main components of the current prescription drug Xuesaitong in China ( 35 ). Xuesaitong is mainly used to treat cardiovascular and cerebrovascular diseases, such as cerebral infarction ( 36 , 37 ) and coronary heart disease ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg1 exerts anti‑apoptotic effects on non‑alcoholic fatty liver cells by downregulating the expression of SGPL1

Xie

Cao

et al. 2022

Mol Med Rep

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Non-alcoholic fatty liver disease (NAFLD) has a high incidence, and can lead to liver cirrhosis and even hepatocellular carcinoma in severe cases. To the best of our knowledge, there is currently no safe and effective treatment for the management of this disease. Ginsenoside Rg1 (Rg1) is an active monomer derived from ginseng and notoginseng. In the present study, HHL-5 hepatocytes were used to establish an in vitro cell model of NAFLD by medium- and long-chain fat emulsion treatment, and the effects of Rg1 on adipose accumulation, apoptosis and the expression levels of apoptosis-related proteins in HHL-5 hepatocytes were examined. The results demonstrated that Rg1 inhibited the accumulation of fat in HHL-5 cells, while inhibiting apoptosis, and Rg1 downregulated the expression levels of the pro-apoptotic protein Bax and upregulated the expression levels of the anti-apoptotic protein Bcl-2, indicating that Rg1 could promote the stability or integrity of mitochondria and exert an anti-apoptotic effect by regulating Bcl-2 family proteins. In addition, Rg1 markedly downregulated the expression levels of sphingosine-1-phosphate lyase 1 (SGPL1), a key enzyme in the sphingosine signaling pathway, in HHL-5 cells with steatosis, and increased the expression levels of the downstream pro-survival signals phosphorylated (p-)Akt and p-Erk1/2. Furthermore, overexpression of SGPL1 abolished the anti-apoptotic effect of Rg1 on SGPL1-overexpressing HHL-5 cells with steatosis, and downregulated the expression levels of pro-survival proteins, such as Bcl-2, p-Akt and p-Erk1/2, whereas the expression levels of pro-apoptotic Bax were markedly increased. In conclusion, although there are some reports regarding the protective effect of Rg1 on fatty liver cells, to the best of our knowledge, the present study is the first to report that Rg1 may exert an anti-apoptotic effect on fatty liver cells by regulating SGPL1 in the sphingosine signaling pathway. Rg1 is the main component of the prescription drug Xuesaitong in China; therefore, the findings of the present study may provide a theoretical molecular basis for the use of Rg1 or Xuesaitong in the treatment of patients with NAFLD.

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“…Dai et al found that aspirin was able to significantly alter the absorption, distribution and disposition of two key active compounds of the herbal formula Xuesaitong, while the herbal formula did not exert a significant effect on aspirin (Dai et al, 2017).…”

Section: Interactions Of Common Otc Painkillers and Herbal Remediesmentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications

Sun

Tsai

2023

Biomedical Chromatography

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Pain is one of the most common reasons for seeking medical intervention, and self‐medication with over‐the‐counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb–drug interactions between traditional herbs and four major pain medications—acetaminophen, aspirin, ibuprofen and naproxen—are compiled and analyzed. In terms of analytical methods, high‐performance liquid chromatography using an isocratic eluent system coupled to biological sample clean‐up is the most common, while a wide variety of detectors have been observed, including a photodiode array, variable wavelength detector, electrochemical detector and tandem mass spectrometer. Both synergistic and anti‐synergistic effects were observed for acetaminophen and aspirin, while only synergistic effects have been found for naproxen. Currently, no interactions have been reported for ibuprofen.

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Pharmacokinetic herb–drug interaction of Xuesaitong dispersible tablet and aspirin after oral administration in blood stasis model rats

Cited by 16 publications

References 20 publications

Critical evaluation of causality assessment of herb–drug interactions in patients

Critical evaluation of causality assessment of herb–drug interactions in patients

Ginsenoside Rg1 exerts anti‑apoptotic effects on non‑alcoholic fatty liver cells by downregulating the expression of SGPL1

Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications

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