Pharmacokinetic herb‐drug interaction between ginger and crizotinib

Revol, Bruno; Gautier-Veyret, Élodie; Arrivé, Capucine; Sam‐Laï, Nathalie Fouilhé; McLeer-Florin, Anne; Pluchart, Hélène; Pinsolle, J.; Toffart, Anne‐Claire

doi:10.1111/bcp.13862

Cited by 23 publications

(30 citation statements)

References 17 publications

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“…Can delay or reduce drug absorption; 1 h time-lag between application [69] Minerals, vitamins, drugs obstruction risk with drugs that inhibit peristaltic movements Opioids Garlic Inhibition of CYP2E1 [70], but not 2D6 and 3A4 [70,71]; induces pGP [72] Cyclosporine, tacrolimus Elevated bleeding risk due to platelet inhibition suspected [53,73]; contradicting clinical data [73,74] Monitor patients on anticoagulants when starting/ending garlic preparations; caution with antiplatelet drugs (NSAIDs, especially ASA) [75][76][77]; cases of interactions with dabigatran (pGP) [78], phenprocoumon (CYP2C9) [79], and crizotinib (CYP3A4, 2C9; pGP) [80]; no effect in a clinical study with warfarin (CYP2C9) [81]; elevated tacrolimus AUC in rats [82] CYP2C9, 3A4 and pGP substrates with narrow therapeutic window, such as cyclosporine, tacrolimus Inhibits platelet aggregation in vitro [83] Caution with anticoagulant and platelet-aggregation inhibiting drugs (NSAIDs) Inhibits UDP1A6 in vitro [86]; CYP3A4 and 2C9 inhibition suspected, but no relevant influence in small clinical studies [87][88][89][90][91]; case report of warfarin interaction, probably due to CYP2C9 inhibition [92] Caution with CYP3A4 and 2C9 substrates with small therapeutic windows (such as cyclosporine)…”

Section: Flaxseedmentioning

confidence: 99%

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Lippert

Renner

2022

JCM

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Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.

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Section: Flaxseedmentioning

confidence: 99%

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Lippert

Renner

2022

JCM

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“…Derivatives of ginger such as gingerol, shogaols, galanolactone, and diterpenoid were also established to reduce nausea and vomiting [92]. Others revealed that the reports of management of nausea and vomiting in cancer patients are also available in the literature [93].…”

Section: Antiemeticmentioning

confidence: 99%

Pharmacological Potentials of Ginger

Balogun¹,

AdeyeOluwa²,

Ashafa³

2020

Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials

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Zingiber officinale, belonging to the family Zingiberaceae, is a popular spice and herb used as delicacy and to manage numerous diseases such as diabetes, hypertension, cancer, ulcer, diarrhea, cold, cough, spasm, vomiting, etc. in folk medicine from China, India, and Arabia Peninsula to other continents of the world including Africa (Nigeria, Egypt, and so on). Though this review is aimed at summarizing the pharmacological potentials of this well-endowed spice, interestingly, we found out that these reported ethnobotanical uses are attributed to a number of inherent chemical constituents including gingerol, 6-, 8-, 10-gingerol, 6-shogaol, 6-hydroshogaol, oleoresin, etc., eliciting various pharmacological effects, not limited to antioxidant, antitumor/anticancer, anti-inflammatory, antihyperglycemic, antihypertensive, anticholesterolemic, antibiotic/antimicrobial, neuroprotective, antiulcer/gastroprotective, antiemetic, hepatoprotective, and antiplatelet aggregation, safety profiles established through a number of studies (in vitro, in vivo, and cell lines), though some of these potentials are yet to be explored. Sadly, even few of these established effects are yet to be experimented in clinical trials, and only until these are intensified would there be prospect toward drug development for preventive and curative treatments. In conclusion, we are able to highlight and sum up the therapeutic implications of ginger and its related derivatives in the management of ailments confronting humanity.

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“…Compelling evidence has shown that some herbal medicines cause serious organ damage, which constrains their clinical application. 25-27…”

Section: Introductionmentioning

confidence: 99%

“…Compelling evidence has shown that some herbal medicines cause serious organ damage, which constrains their clinical application. [25][26][27] The anti-fibrotic and anti-hepatocarcinoma properties may rest with either the suppression of cell proliferation or the induction of cell death, which would be reflected by a change in cell viability. The ultimate objective of this study was to investigate the cell death patterns induced by TFPCE and Th-A.…”

Section: Introductionmentioning

confidence: 99%

Nonselective Cell Necrosis Mediated by the Total Flavones of Penthorum Chinensis Pursh and Thonningianin-A in Human Hepatic and Hepatoma Cells

Shen

Guo

et al. 2022

Natural Product Communications

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Penthorum chinensis Pursh (PCP), family Penthoraceae, has been used for hundreds of years in China. With the launch of PCP tablets, clinical applications focused on liver fibrosis and hepatocarcinoma. The purpose of this research was to explore the selectivity and toxicity of the active pharmacodynamic ingredients of PCP in vitro. The total flavones of PCP (TFPCE) and thonningianin-A (Th-A), a major flavone in TFPCE, were investigated on the cell death patterns in human hepatoma cells (HepG2) and human hepatic cells (LO2), followed by a concentration detection of LDH in the supernatants. Apoptosis and necrosis detection kits were used to validate the patterns of cell death caused by TFPCE and Th-A. Finally, the cytotoxicity of both TFPCE and Th-A were reproduced in the colorectal adenocarcinoma cells (NCI-H716). The results indicated that TFPCE inhibits the cell viability of HepG2 cells at a concentration lower than 25 μg/mL. Alternatively, the cell viability of LO2 cells dramatically decreased in the treatment of TFPCE at 25 μg/mL. The effects of Th-A on the cell viability of HepG2 cells and LO2 cells were consistent with TFPCE. LDH detection indicated that TFPCE and Th-A increased the LDH concentration of the supernatants in a dose-dependent way, indicating the pattern of cell necrosis. Fluorescence staining verified the necrosis cell death caused by TFPCE and Th-A. A dose-dependent tendency was obtained in NCI-H716 cells, indicating that the cell viability of NCI-H716 cells was significantly suppressed with the treatment of TFPCE and Th-A. Our results bring the potential toxicity of PCP to the forefront of public attention. Therefore, the clinical application of P chinensis is required to focus more on its cytotoxic effect.

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Pharmacokinetic herb‐drug interaction between ginger and crizotinib

Cited by 23 publications

References 17 publications

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Pharmacological Potentials of Ginger

Nonselective Cell Necrosis Mediated by the Total Flavones of Penthorum Chinensis Pursh and Thonningianin-A in Human Hepatic and Hepatoma Cells

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