Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats

Xu, Shixi; Peng, Jun; Li, Yuan‐Jian; He, Lingyun; Chen, Fei; Jie, Zhang; Ding, Jinsong

doi:10.1016/j.jep.2011.11.023

Cited by 31 publications

(12 citation statements)

References 17 publications

(26 reference statements)

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“…The C max of rutaecarpine has been reported to be 2.4 ± 3.0 ng/ml after oral administration of 40 mg/kg to rats for 18 days. Levels of rutaecarpine and evodiamine detected in vivo from TR extracts are much higher (22.8 ± 4.4 and 78.8 ± 23.5 ng/ml, respectively) than that of rutaecarpine alone and evodiamine alone given to rats at similar concentrations (Ding et al, 2008;Xu et al, 2012).…”

Section: Pharmacokinetic Parametersmentioning

confidence: 87%

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

et al. 2020

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Herbal medicine is a major part of traditional Chinese medicine (TCM), which is evolved as a system of medical practice from ancient China. The use of herbal medicine is mainly based on practice and theories and concepts rooted in ancient philosophy. In the era of evidence-based medicine, it is essential to accurately evaluate herbal remedy with standard/modern medical practice approaches. Tetradium ruticarpum (A. Juss.) Hartley (TR), a medicinal plant with diversify bioactive components, has been broadly used to treat pain and gastrointestinal disorders in TCM. However, TR has also been reported to have potential toxicity by long-term use or excessive doses, though the associated compounds are yet to be identified. TR is usually processed, and/or combined with other herbs in TCM formulas in order to achieve a synergistic effect or reduce its toxicity. Since processing or polyherbal formulation of TR may lead to changes in its chemical composition and contents, quality, efficacy and toxicity, comparison of TR samples before and after processing, as well as its combination with other medicines, would provide useful knowledge of bioactive compounds, efficacy and toxicity of this valuable medicinal plant. Here we reviewed the recent studies about the phytochemistry, pharmacokinetic behaviors and toxicity of TR under various processing or polyherbal formulation conditions, which would expand our understanding of mechanisms of TR's efficacy and toxicity and be valuable for quality control in industrial manufacturing, future medicinal research, and safety and rational use of TR in TCM.

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Section: Pharmacokinetic Parametersmentioning

confidence: 87%

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

et al. 2020

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“…Benth ( Tetradium ruticarpum ), is a well-known Chinese herbal drug that has been used to treat hypertension for hundreds of years ( 10 ). Modern pharmacological research isolated a quinazolinocarboline alkaloid from Wu-Chu-Yu, which is termed rutaecarpine ( 11 , 12 ). Previous studies have demonstrated the role of rutaecarpine in decreasing blood pressure in a number of animal models, including spontaneously hypertensive rats (SHR) and 2-kidney and 1-clip rats ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine

et al. 2018

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The traditional Chinese herb Wu-Chu-Yu has been used to treat hypertension for hundreds of years. A previous study indicated that rutaecarpine was the effective component of Wu-Chu-Yu, which lowered blood pressure by elevating the expression level of calcitonin gene-related peptide (CGRP). The present study was performed to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in CGRP expression and release induced by rutaecarpine. Dorsal root ganglia (DRG) obtained from Sprague-Dawley rats were cultured to analyze the mRNA expression and release of CGRP. Calcium influx, as an indicator of TRPV1 activation, was measured in 293 cells with stable overexpression of TRPV1. The results demonstrated that the amount of CGRP in the cell culture supernatant and the mRNA expression of CGRPα and CGRPβ in DRG was upregulated by rutaecarpine in a concentration-dependent manner, and was inhibited by the TRPV1 receptor antagonist capsazepine. In addition, intracellular Ca2+ levels were increased by Rut in the aforementioned 293 cell line, indicating the activation of TRPV1 by Rut. Therefore, it was concluded that TRPV1 was involved in the expression and release of CGRP stimulated by rutaecarpine, which provided novel mechanistic understanding of the treatment of hypertension using the Chinese herb Wu-Chu-Yu.

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“…Evodiae fructus , also known as Wu-Chu-Yu, is the immature fruit with stems of Evodia rutaecarpa Benth (ER). ER is widely used in TCM for the treatment of inflammation, headache, diarrhea, and hypertension [ 4 , 11 , 12 ]. Our previous in vitro study revealed that ZJW inhibits the activities of activator protein 1 (AP-1) and nuclear factor-κB (NF-κB), as well as cellular transformation in HepG2 cells [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice

Chou

Hsiang

et al. 2017

BMC Complement Altern Med

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BackgroundZuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mechanisms of ZJW and its alkaloid components on cancers are still unclear.MethodsHere we investigated the anti-cancer effects and mechanisms of ZJW, CC, ER, berberine, and evodiamine in cells and in intrahepatic xenograft mice.ResultsTreatment of HepG2 cells with ZJW, CC, ER, berberine, and evodiamine significantly displayed cytotoxic effects in a dose- and time-dependent manner. Hierarchical cluster analysis of gene expression profiles showed that CC and ZJW shared a similar mechanism for the cytotoxic effects, suggesting that CC was the active ingredient of ZJW for anti-cancer activity. Network analysis further showed that c-myc was the likely key molecule involved in the regulation of ZJW-affected gene expression. A human hepatoma xenograft model was established by intrahepatic injection of HepG2 cells containing nuclear factor-κB-driven luciferase genes in immunocompetent mice. In vivo bioluminescence imaging showed that cells had been successfully transplanted in mouse liver. Oral administration of ZJW for 28 consecutive days led to a significant decrease in the accumulation of ascites, the ratio of tumor-to-liver, and the number of transplanted cells in livers.ConclusionsIn conclusion, our findings suggested for the first time that ZJW significantly suppressed human cancer cell growth in orthotopic HepG2 xenograft-bearing immunocompetent mice. Moreover, c-myc might play a potent role in the cytotoxic mechanisms of ZJW, CC, ER, berberine, and evodiamine.

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Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats

Cited by 31 publications

References 17 publications

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine

Exploration of anti-cancer effects and mechanisms of Zuo-Jin-Wan and its alkaloid components in vitro and in orthotopic HepG2 xenograft immunocompetent mice

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