Pharmacokinetic Comparison of 20(R)‐ and 20(S)‐Ginsenoside Rh1 and 20(R)‐ and 20(S)‐Ginsenoside Rg3 in Rat Plasma following Oral Administration of Radix Ginseng Rubra and Sheng‐Mai‐San Extracts

Fan, Xiaomei; Xu, Yan; Zhu, Daling; Ji, Yibing

doi:10.1155/2017/6451963

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…[ 26 ] KYU'S and Xiaomei Fan demonstrated RG can modulate antioxidant enzymes, which has biochemical and functional effects for the heart. [ 27 , 28 ] Studies have shown that Radix Aconiti Lateralis Preparata and its active component can improve left ventricular systolic and diastolic function, which is of great importance to improve chronic HF. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Nuanxin capsule for heart failure

et al. 2018

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ObjectiveTo assess the efficacy and safety of Nuanxin capsule for patients with heart failure (HF).MethodsA systematic literature search was performed in 6 databases: PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan-fang Data Information Site, Chinese BioMedical Database (CBM), VIP Chinese Science and Technique Journals Database from the date of its inception up to November 2016. Review Manager 5.2 software was used for assessment of risk of bias, data synthesis and subgroup analysis. Begg and Egger tests were used for assessing symmetries of funnel plot by software Stata 12.0. We conducted the GRADE system to assess the quality of evidence.Results12 trials involving 1418 participants were eligible. Compared with western medicine (WM) alone, Nuanxin capsule plus WM showed statistical significance in total effective rate (RR 1.18, 95% condidence interval [CI] 1.13–1.25). According to subgroup analysis, the 6-months group and the 12-months group have better effect than the 3-month group. As for 6-minute walking distance (6MWT), Nuanxin capsule plus WM compared with WM has significantly increased walking distance (weighted mean difference [WMD] 42.56, 95% CI 34.27–50.85). Nuanxin capsule plus WM has significantly decreased in mortality (RR 0.29, 95% CI 0.18–0.46) and re-admission rate (RR 0.48, 95% CI 0.39–0.60) compared with WM. Nuanxin capsule plus WM was beneficial for B-type natriuretic peptide (−240.47, 95% CI −332.45–148.49). gger's and Begg's test showed that there was no publication bias exist (P = .937). Influence analysis showed that no single study affected the overall result. The GRADE quality of the evidence was very low to Moderate across the different outcomes.ConclusionsDespite of the apparently positive findings, we cannot draw a sound conclusion that Nuanxin capsule has positive effect in patients with HF, because of the insufficient evidence.

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Section: Discussionmentioning

confidence: 99%

Nuanxin capsule for heart failure

et al. 2018

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“…Various methods were developed for studying pharmacokinetics of complex mixtures. High-pressure liquid chromatography mass spectrometry techniques (HPLC MS) can be used for specific and sensitive detection of individual active compounds in blood plasma, taking into account their stereochemistry [ 23 ]. Different modifications of HPLC MS allow for simultaneous detection of up to ten individual components of plant extracts in biological samples [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

A Use of Tritium-Labeled Peat Fulvic Acids and Polyphenolic Derivatives for Designing Pharmacokinetic Experiments on Mice

et al. 2021

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Natural products (e.g., polyphenols) have been used as biologically active compounds for centuries. Still, the mechanisms of biological activity of these multicomponent systems are poorly understood due to a lack of appropriate experimental techniques. The method of tritium thermal bombardment allows for non-selective labeling and tracking of all components of complex natural systems. In this study, we applied it to label two well-characterized polyphenolic compounds, peat fulvic acid (FA-Vi18) and oxidized lignin derivative (BP-Cx-1), of predominantly hydrophilic and hydrophobic character, respectively. The identity of the labeled samples was confirmed using size exclusion chromatography. Using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT ICR MS), key differences in the molecular composition of BP-Cx-1 and FA-Vi18 were revealed. The labeled samples ([3H]-FA-Vi18 (10 mg/kg) and [3H]-BP-Cx-1 (100 mg/kg)) were administered to female BALB/c mice intravenously (i.v.) and orally. The label distribution was assessed in blood, liver, kidneys, brain, spleen, thymus, ovaries, and heart using liquid scintillation counting. Tritium label was found in all organs studied at different concentrations. For the fulvic acid sample, the largest accumulation was observed in the kidney (Cmax 28.5 mg/kg and 5.6 mg/kg, respectively) for both routes. The organs of preferential accumulation of the lignin derivative were the liver (Cmax accounted for 396.7 and 16.13 mg/kg for i.v. and p.o. routes, respectively) and kidney (Cmax accounted for 343.3 and 17.73 mg/kg for i.v. and p.o. routes, respectively). Our results demonstrate that using the tritium labeling technique enabled successful pharmacokinetic studies on polyphenolic drugs with very different molecular compositions. It proved to be efficient for tissue distribution studies. It was also shown that the dosage of the polyphenolic drug might be lower than 10 mg/kg due to the sensitivity of the 3H detection technique.

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“…Recently, Rg3 has been studied for the different efficacy of two forms. (Kwok et al, 2012;Fan et al, 2017;}. Among many ginsenoside saponins, Rg3 is well known in the public, but not much research has been done, such as Rb1, Rg1, and Rb2.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Ginsenoside Rg3 and Metabolic Syndrome

et al. 2020

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Metabolic syndrome is an important public health issue and is associated with a more affluent lifestyle. Many studies of metabolic syndrome have been reported, but its pathogenesis remains unclear and there is no effective treatment. The ability of natural compounds to ameliorate metabolic syndrome is currently under investigation. Unlike synthetic chemicals, such natural products have proven utility in various fields. Recently, ginsenoside extracted from ginseng and ginseng root are representative examples. For example, ginseng is used in dietary supplements and cosmetics. In addition, various studies have reported the effects of ginsenoside on metabolic syndromes such as obesity, diabetes, and hypertension. In this review, we describe the potential of ginsenoside Rg3, a component of ginseng, in the treatment of metabolic syndrome.

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Pharmacokinetic Comparison of 20(R)‐ and 20(S)‐Ginsenoside Rh1 and 20(R)‐ and 20(S)‐Ginsenoside Rg3 in Rat Plasma following Oral Administration of Radix Ginseng Rubra and Sheng‐Mai‐San Extracts

Cited by 8 publications

References 32 publications

Nuanxin capsule for heart failure

Nuanxin capsule for heart failure

A Use of Tritium-Labeled Peat Fulvic Acids and Polyphenolic Derivatives for Designing Pharmacokinetic Experiments on Mice

Relationship Between Ginsenoside Rg3 and Metabolic Syndrome

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