Pharmacokinetic and pharmacodynamic interactions of Tinospora cordifolia aqueous extract and hypoglycemic drugs in streptozotocin-induced diabetes in rats

Vora, Amisha; Varghese, Alice; Kachwala, Yusuf; Laddha, Ankit P.; Bhaskar, Emmanuel; Akhtar, Jamal; Yadav, Pawan Kumar

doi:10.4103/pm.pm_272_19

Cited by 4 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an another study on mice the pharmacodynamic interactions between TC extracts and anti-diabetic drugs [Metformin(MET), sitagliptin(SITA), glibenclamide(GLI)] was studied and seen that the combination of TC extract in dosage 400mg/kg with each of this drug (MET-90mg/kg, SITA-10mg/kg, GLI-1mg/kg) leads to the reduction of blood glucose levels in fasting. It is also seen to normalise the symptoms of dyslipidemia by reducing the levels of total cholesterol and triglycerides (Vora et al, 2020).…”

Section: Medical Applicationsmentioning

confidence: 99%

Tinospora Cordifolia: A Magical Wand With Immense Medicinal Applications

Arora¹

2021

PLANT ARCHIVES

View full text Add to dashboard Cite

Tinospora cordifolia, a herb with a potential of boosting the immune system of a person is fully packed with nutrition be it carbohydrates, vitamin C, protein, fat, bioactive phytochemicals etc which one can have for relieving the person from illness and providing significant health benefits. When it comes to healthy herbs and plants Tinospora cordifolia never fails as a choice to cure the diseases and the symptoms associated with it. It helps in the treatment and management of diabetes, cancer, HIV-AIDS, toxicity from aflatoxins, osteoporosis, inflammation, leprosy, arthritis etc by the helps of various phytochemicals present in it. Alkaloids like Tinocordiside, Palmatine, Magnoflorine helps in cancer, syringin works as a great anti-allergen, magnoflorine as an anti-inflammatory etc.

show abstract

Section: Medical Applicationsmentioning

confidence: 99%

Tinospora Cordifolia: A Magical Wand With Immense Medicinal Applications

Arora¹

2021

PLANT ARCHIVES

View full text Add to dashboard Cite

show abstract

“…Coadministration of the TC aqueous extract (TCE) with the commonly prescribed oral hypoglycemic drugs (metformin, sitagliptin, and glibenclamide) in the therapeutic management of diabetes mellitus showed no significant pharmacokinetic interaction. Instead, it offered a significant improvement in the glycemic control and the conditions associated with diabetes mellitus in streptozotocin-induced diabetic male albino rats, proving safety and efficacy for the combination therapy of TCE with the above standard drugs in the management of diabetes and associated conditions [47]. Improved wound healing efficacy was observed with a combination of the oral TC methanolic extract and the local insulin therapy in alloxan-induced diabetic rats [48].…”

Section: Anti-hyperglycemic Activitymentioning

confidence: 99%

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Priya¹,

Balasubramanian²,

Shanmugaraj³

et al. 2022

Phyton

View full text Add to dashboard Cite

For thousands of years, plant based herbal medicines have been utilized by millions of people all over the world. Plant materials or products are used in different folk/traditional medical systems, such as the Chinese, African and Indian medical systems, like Siddha, Ayurveda, Unani, and Homeopathy. Tinospora cordifolia (TC) is a medicinal plant belonging to the family Menispermaceae. It is a big deciduous, climbing shrub growing prevalently in the tropical part of Indian subcontinent regions such as India, Pakistan, Nepal, Bhutan, Bangladesh and Srilanka, and in Myanmar, and China. Guduchi, Giloy, Shindilkodi, and Amritha are all the common names for this plant. Extracts from different parts of this herbal plant have been used to treat many diseases. In Ayurvedic medicine, extract from this plant is used for preparing "rasayanas", which is known to cure diabetes, skin diseases, allergic conditions, jaundice, cardiovascular diseases, rheumatoid arthritis, poisoning, and microbial infections. T. cordifolia has a many bioactive phytochemicals that have been isolated from its aerial parts and roots. Many bioactive principles have been reported from this plant which belong to various classes like alkaloids, aliphatic compounds, diterpenoid lactones, phenolics, flavonoids, glycosides, sesquiterpenoids, lignans, steroids and polysaccharides. T. cordifolia possesses medicinal properties such as antioxidant, antiallergic, antiinflammatory, antimicrobial, antiviral, antidote, antitumor, antileprotic, antispasmodic, and antidiabetic properties. The present review will provide a comprehensive therapeutic potential of T. cordifolia.

show abstract

“…for 28 days in STZ‐induced diabetes rats, no pharmacokinetic interactions were observed. However, improvement was observed in glycemic control and the conditions associated with diabetes mellitus (Vora et al, 2020). Thus, owing to in vivo inhibitory action against CYP1A2, 2C9, 2C19, 2D6, and 3A4, Tinospora cordifolia has potential to interact with several hypoglycemic agents.…”

Section: Selection Criterionmentioning

confidence: 99%

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Thikekar

Thomas

Chitlange

2021

Phytotherapy Research

View full text Add to dashboard Cite

Global diabetes epidemic is the major cause of fatality and lethality. As per IDF 2019 report, diabetes caused 4.2 million deaths, approximately 463 million people are living with diabetes and by 2045, this will rise to 700 million. Nowadays, the physicians and common people in both developed and developing countries are using medicinal plants and their formulations to treat diseases with the postulation that organic commodities are safe for consumption. These plants may act as inhibitors or inducers of the Cytochrome P450 or transport and efflux proteins or both and may alter gastrointestinal, renal functions leading to Herb‐Drug Interactions. This review intends to focus on the frequently employed medicinal plants, their traditional uses, their Cytochrome P450 inhibition or induction activity, phytochemical, and pharmacological effects, established HDI with the help of in vitro tools, in vivo pharmacokinetics and pharmacodynamics studies to understand the impact of herbs on ADME of the drug and whether it is beneficial, harmful or has no effect respectively. This review will help the physicians and other health care professionals as a reference guide to update their knowledge and expertise about HDI. However, more quality research in this area is needed to evaluate the efficacy of many herbal medicines, thereby reducing side effects and improving the safety of patients.

show abstract

Pharmacokinetic and pharmacodynamic interactions of Tinospora cordifolia aqueous extract and hypoglycemic drugs in streptozotocin-induced diabetes in rats

Cited by 4 publications

References 34 publications

Tinospora Cordifolia: A Magical Wand With Immense Medicinal Applications

Tinospora Cordifolia: A Magical Wand With Immense Medicinal Applications

Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

Contact Info

Product

Resources

About