volume 21, issue 3, P821-846 2007
DOI: 10.1016/j.idc.2007.07.004
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Scott J. Bergman, Cristian Speil, Michael Short, Janak Koirala

Abstract: The study of pharmacokinetics includes the absorption, distribution, metabolism, and elimination of drugs. The pharmacologic effect that a medication has on the body is known as pharmacodynamics. With antimicrobials, pharmacokinetic and pharmacodynamic parameters become especially important because of the association between host drug concentrations, microorganism eradication, and resistance. This article focuses on the pharmacokinetic changes that can occur with antimicrobials when they are used in patients a…

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