Pharmacognostical Evaluation, Phytochemical Analysis and Antioxidant Activity of the Roots of Achillea tenuifolia LAM.

Manayi, Azadeh; Mirnezami, Tahmineh; Saeidnia, Soodabeh; Ajani, Yousef

doi:10.5530/pj.2012.30.3

Cited by 19 publications

(19 citation statements)

References 5 publications

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“…In some studies, radical-scavenging activities of the plant extracts were tested. [ 62 63 ] For this plant, antioxidant activity compared with the alkamides and cichoric acid that are the characteristic compounds of Echinacea . The free radical-scavenging activity of the extracts was related to their cichoric acid contents, while alkamides were inactive against free radicals.…”

Section: Biological Activitymentioning

confidence: 99%

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods

Manayi¹,

Vazirian²,

Saeidnia³

2015

Phcog Rev

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159

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Echinacea purpurea (Asteraceae) is a perennial medicinal herb with important immunostimulatory and anti-inflammatory properties, especially the alleviation of cold symptoms. The plant also attracted scientists’ attention to assess other aspects of its beneficial effects. For instance, antianxiety, antidepression, cytotoxicity, and antimutagenicity as induced by the plant have been revealed in various studies. The findings of the clinical trials are controversial in terms of side effects. While some studies revealed the beneficial effects of the plant on the patients and no severe adverse effects, some others have reported serious side effects including abdominal pain, angioedema, dyspnea, nausea, pruritus, rash, erythema, and urticaria. Other biological activities of the plant such as antioxidant, antibacterial, antiviral, and larvicidal activities have been reported in previous experimental studies. Different classes of secondary metabolites of the plant such as alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins are believed to be biologically and pharmacologically active. Actually, concurrent determination and single analysis of cichoric acid and alkamides have been successfully developed mainly by using high-performance liquid chromatography (HPLC) coupled with different detectors including UV spectrophotometric, coulometric electrochemical, and electrospray ionization mass spectrometric detectors. The results of the studies which were controversial revealed that in spite of major experiments successfully accomplished using E. purpurea, many questions remain unanswered and future investigations may aim for complete recognition of the plant's mechanism of action using new, complementary methods.

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Section: Biological Activitymentioning

confidence: 99%

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods

Manayi¹,

Vazirian²,

Saeidnia³

2015

Phcog Rev

Self Cite

159

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“…The plant extract activity against free radical was examined by DPPH method which described previously [23]. The absorptions at 517 nm were measured after 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…Total phenolics content of the plant extract was examined and expressed as gallic acid equivalent (μg GAE/ mg EXT) using Folin Ciocalteu method [23]. The sample absorbance was compared to gallic acid calibration curve.…”

Section: Methodsmentioning

confidence: 99%

Biological activity and microscopic characterization of Lythrum salicaria L

et al. 2013

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BackgroundThere are several plants have been used worldwide in the folk medicine with high incidence for treatment of human disorders, of which Lythrum salicaria belongs to the Lythraceae family has traditionally reputation for some medicinal usage and recently many biological and pharmacological activity of the plant have been studied.MethodsIn this study, microscopic characterizations of the aerial parts of the plant were determined. Moreover, the plant extract (aqueous methanol 80%) was subjected to an anti-diabetic activity test (in a rat model of streptozocin induced diabetes), anti-Helicobacter pylori (using disc diffusion method) along with antioxidant activity against DPPH (stable free radical) tests. Besides, total flavonoids, phenols, tannins, as well as polysaccharides contents have been assessed using spectroscopic methods.ResultsThe microscopic properties of the plant fragments revealed anomocytic stomata, conical shape trichomes, and abundant spherical pollen grains as a characteristic pattern for the aerial parts of the plant. The extract of the plant at concentration of 15 g/kg showed mild lowering activity on blood glucose level to 12.6% and 7.3% after 2 and 3 h of administration. Additionally, clinically isolated H. pylori strain was inhibited with the plant extract at concentration of 500 mg/mL (zone of inhibition: 17 ± 0.08 mm). Moreover, IC50 values for DPPH inhibition of the plant extract, vitamin E, BHA were examined as 13.5, 14.2, and 7.8 μg/mL, respectively. Total flavonoids, phenols, tannin, and polysaccharides contents of the extract were successfully evaluated as 5.8 ± 0.4 μg QE/mg EXT, 331 ± 3.7 μg GAE/mg EXT, 340 ± 2.3 μg TAE/mg EXT, 21 ± 0.2 μg GE/mg EXT, respectively.ConclusionsThe results suggested that L. salicaria has low anti-diabetic and anti-Helicobacter pylori effects, but high antioxidant activity, just the same as positive standard (vitamin E), which might be attributed to the high content of phenolic compounds in the extract.

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“…The previous study revealed that the oil of the plant compromised of several monoterpenes and sesquiterpenes [ 9 - 12 ]. There is also a report on the phytochemical content of the root extract demonstrating the presence of tannins, sterols and terpenoids [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Presence of phthalate derivatives in the essential oils of a medicinal plant Achillea tenuifolia

et al. 2014

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BackgroundPhthalate, esters of phthalic acid, are mainly applied as plasticizers and cause several human health and environment hazards. The essential oils of Achillea species have attracted a great concern, since several biological activities have been reported from varieties of these medicinal species. On the other side, due to the problems regarding the waste disposal in developing countries, phthalate derivatives can easily release from waste disposal to the water and soil resulting in probable absorption and accumulation by medicinal and dietary plants. As a matter of fact, although the toxicity of phthalate derivatives in human is well-known, food crops and medicinal plants have been exposing to phthalates that can be detected in their extracts and essential oils. Achillea tenuifolia (Compositea) is one of these herbaceous plants with traditional applications which widely growing in Iran.FindingThe plant root was subjected to hydro-distillation for 4 h using Clevenger type apparatus to obtain its essential oil before and after acid treatment. Both of the hydro-distilled essential oils were analysed by GC-MS method resulted in recognition of their constituent. Phthalate contamination as (1, 2-benzenedicarboxylic acid, bis (2-methylpropyl) ester (5.4%) and phthalic acid (4.5%), were identified in the first and second extracted oils, respectively.ConclusionAs a warning, due to the potential role of phthalates to cause reproductive toxicity, disturb of endocrine system and causing cancers, medicinal plants have to be considered through quality control for detection of these compounds.

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Pharmacognostical Evaluation, Phytochemical Analysis and Antioxidant Activity of the Roots of Achillea tenuifolia LAM.

Cited by 19 publications

References 5 publications

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods

Biological activity and microscopic characterization of Lythrum salicaria L

Presence of phthalate derivatives in the essential oils of a medicinal plant Achillea tenuifolia

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