Pharmacognostical and Pharmacological Review on <i>Tridax procumbens Linn</i>

Ahmed, Syed Sagheer; Prakash, K. V.; Tabassum, Saba; Salma, Noor; Devi, K

doi:10.5958/2321-5836.2019.00003.x

Cited by 6 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some people regard these plants as valuable because they were created with the intention of providing man with food, medicinal treatment, and other benefits [7]. Herbal remedies Both emerging and industrialized nations engage in considerable research, and in recent years, the need for plant-based medications has increased [8].…”

Section: IImentioning

confidence: 99%

Evaluation of antimicrobial activity of hydro-alcoholic extract of thunbergia fragrans

M¹,

Aishwarya²,

Balu³

et al. 2022

J Pharm Med H Sci

View full text Add to dashboard Cite

Hydroalcoholic extract of Thunbergia fragrans was investigated for phytochemical as well as Anti-microbial screening. Phytochemical evaluation of the plant extract revealed the presence of Flavonoids, Phenols, Tannins, and other constituents. The extract was prepared by maceration technique, the solvent was used in ratio of 70:30 [ethanol: water]. The obtained hydro alcoholic extract was tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus. Whereas the extract showed no significant antimicrobial effects even though Thunbergia Fragrans is believed to be used to treat open wounds in Indian siddha medicine, further studies are required to find out the full potential of the plant.

show abstract

Section: IImentioning

confidence: 99%

Evaluation of antimicrobial activity of hydro-alcoholic extract of thunbergia fragrans

M¹,

Aishwarya²,

Balu³

et al. 2022

J Pharm Med H Sci

View full text Add to dashboard Cite

show abstract

“…20 The research to observe drug design needs a long time, but screening to find out potential compounds as drug candidates at this time, the in silico approach can be used. 21,22,23 In silico is a research approach that uses computer simulation and available database information. 24 This computation method can predict the interaction between ligand and target protein, as well as its bond energy.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Study of 7,8-Dihydroxyflavone as a Neuroprotective Agent in Ischemic Stroke via TRKB Regulation and Glutaminase Inhibition

Muhammad,

Adnani,

Arviana

et al. 2023

MNJ

View full text Add to dashboard Cite

Background: Stroke, particularly ischemic stroke, is one of the leading causes of death worldwide. Ischemic stroke causes a failure of oxidative phosphorylation and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, all of which result in cell death. Neuroprotective agents are given to prevent the infarct area from expanding. Objective: This study aims to predict an in silico interaction by 7,8-dihydroxyflavone as neuprotective agent through TrkB signaling and inhibiting Glutaminase activity. Methods: In silico simulation with 7,8-dihydroxyflavone (DHF) as neuroprotective agent using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol software. This study analyzes the pharmacokinetics, pharmacodynamics, and protein-ligand interactions between 7,8-DHF as a ligand with TrkB (4AT5) and Glutaminase (5JYO) as protein target, compared to their native ligand. Results: 7,8 DHF binds to 4AT5 and 5JYO with lower bond energy (-9.4 Kcal/mol and -6.3 Kcal/mol, respectively) than the native ligand (-5 Kcal/mol and -5.9 Kcal/mol, respectively). It means that 7,8-DHF may increase protective mechanism. Conclusion: These findings tend to increase downstream signaling pathways, leading to increased TrkB expression, which induces protective mechanisms, and decreased glutamate expression, which reduces glutamate toxicity.

show abstract

“…The increasing ischemic stroke prevalence, along with a few effective treatments, there is the urgent need for more research to find safe and effective neurotherapeutics that affect the pathophysiological pathways and reduce the ischemic stroke prevalence. 10,11 The development of neuroprotective agents can be used to prevent spreading the infarct area by the activation of endogenous neurotrophins mechanism, such as BDNF that can reduce cell damage due to blood flow obstruction. 6,12 TrkC signaling may play an important role as a neuroprotector by neuron survival mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…19 Long-term research is required to examine therapeutic discovery, but in the meantime, in silico screening can be performed to discover molecules that would make decent therapeutic candidates. 20,21,11 A study strategy known as in silico makes use of database data and computer simulation. 22 This computational technique can projected the bond energy and interaction between the ligand and the target protein.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotectant of 7,8-Dihydroxyflavone in Ischemic Stroke Through Modulation Glutathione S-Transferase and Tyrosine Receptor Kinase C: A Bioinformatics Study

Violita,

Arviana,

Muhammad

et al. 2023

MNJ

View full text Add to dashboard Cite

Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide. Several biological mechanisms underlying this disease such as failure of glutamate reuptake and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, resulted in cell death and brain tissue damage. Neurotherapeutics agents are given to affect the pathophysiological pathways and prevent expanding infarct area. Objective: This study aims to analyze the modulation of Gluthatione S-Transferase (GST) and Tyrosine kinase receptor C (TrkC) by 7,8-DHF as neuroprotective agent in ischemic in silico. Methods: This study used in silico simulation to predict 7,8-dihydroxyflavone (DHF) as neuroprotective agent by using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol. This study analyzes the pharmacodynamics, pharmacokinetics, and molecular interactions between 7,8-DHF as a ligand with GST (13GS) and TrkC (6KZC) as protein target, compared to their native ligand. Results: 7,8-DHF may increase intracellular endogenous antioxidants mainly GST and stimulate TrkC to activate further neuron survival signaling. 7,8 DHF has a much lower bond energy (-8.1 Kcal/mol) when it binds to GST compared to the native ligand (-5.9 Kcal/mol). Besides, binding affinity between 7,8-DHF-TrkC was -9 Kcal/mol, while native ligand-TrkC was -10.6 Kcal/mol. This study showed that there were the same amino acid residues between 7,8-DHF-GST and 7,8-DHF-TrkC, compared to their native ligand. Conclusion: As an adaptive response to hypoxia caused by ischemic stroke, these findings are likely to induce protective mechanism through indirectly TrkC activation which regulates neurogenesis and increasing intracellular endogenous antioxidants.

show abstract

Pharmacognostical and Pharmacological Review on Tridax procumbens Linn

Cited by 6 publications

References 0 publications

Evaluation of antimicrobial activity of hydro-alcoholic extract of thunbergia fragrans

Evaluation of antimicrobial activity of hydro-alcoholic extract of thunbergia fragrans

Bioinformatics Study of 7,8-Dihydroxyflavone as a Neuroprotective Agent in Ischemic Stroke via TRKB Regulation and Glutaminase Inhibition

Neuroprotectant of 7,8-Dihydroxyflavone in Ischemic Stroke Through Modulation Glutathione S-Transferase and Tyrosine Receptor Kinase C: A Bioinformatics Study

Contact Info

Product

Resources

About