Pharmacognostic and phytochemical studies on Ayurvedic drugs Ativisha and Musta

Adams, Sebastian John; Kuruvilla, Gina R.; Krishnamurthy, K. V.; Muthialu, Nagarajan; Venkatasubramanian, Padma

doi:10.1590/s0102-695x2013005000040

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…The production of data on leaf histochemistry is of great importance for the quality control of raw materials in the production of phytotherapeutic agents (Adams et al, 2013;Andrade et al, 2017;Santos et al, 2013). Based on histological data, new species with pharmacological potential can be studied as to the chemical nature of their cellular compounds (Oliveira et al, 2015;Vasconcelos et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Histochemical Screening of Leaves Compared to in situ and in vitro Calluses of Solanum aculeatissimum Jacq.

Dantas¹,

Melo²,

Pereira³

et al. 2017

JAS

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Solanum aculeatissimum Jacq. is a shrub considered to have valuable medicinal potential in folk medicine in China and Nepal. The fruit extract is used for toothache, scabies, headache, dandruff and lice infestation. A limited number of reports address techniques of tissue culture for this plant. Therefore, the objective of the present study was to establish the species in vitro from seeds and subsequently to compare the production of primary and secondary metabolites in the plant's leaves in situ and in vitro and in calluses obtained from leaf segments. Seedlings were established from seeds in Murashige and Skoog (MS) medium with a 50% salt concentration.The seedlings were kept under a photoperiod of 16 h of photosynthetically active radiation at 45-55 µmol m -2 s -1 provided by fluorescent bulbs. The callus induction experiment followed a completely randomized design consisting of 2 doses of kinetin (KIN), 2.5 and 10 mg L -1 , in the absence or presence of light. Segments were inoculated in glass bottles containing 50% MS medium, 30 g L -1 of sucrose, 3.5 g L -1 of agar and 1 mg L -1 of 2,4-D (2,4-dichlorophenoxyacetic acid), with the pH adjusted to 5.7±0.03. We observed that in vitro cultivation of calluses resulted in greater secondary metabolite production and accumulation, regardless of KIN concentration. In calluses, the best alternative for potentiation occurred in cultivation in the absence of light when compared to the tissues of both in situ and in vitro leaves.

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Section: Introductionmentioning

confidence: 99%

Histochemical Screening of Leaves Compared to in situ and in vitro Calluses of Solanum aculeatissimum Jacq.

Dantas¹,

Melo²,

Pereira³

et al. 2017

JAS

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“…A interpretação dos resultados histoquímicos permite a comparação de órgãos, espécie ou materiais provenientes de diferentes ambientes ou épocas (ADAMS et al, 2013). O Lugol é constituído por Iodeto de Potássio (KI), um sal iônico que provoca a ruptura das pontes de hidrogênio e a consequente separação das várias unidades de glucose que constituem a macromolécula de amido, desta forma o KI permite que o iodo se acumule na molécula de amido .…”

Section: Metodologia De Pesquisa De Campounclassified

Ciências biológicas: as diversas manifestações da vida

2023

Ciências Biológicas: As Diversas Manifestações Da Vida

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“…[3] The therapeutic potential of Aconitum spp. have been scientifically validated for neurological effects on CNS, [4] antiproliferative, [5] anti-microbial, [6] and anti-rheumatism activity. [7] The pharmacological effects of Aconitum roots, the official part of the plant, are attributed to a diverse array of secondary metabolites, including flavonoids, phenolic acids, diterpenoid alkaloids, phenylpropanoids; [8,9] Aconitum spp.…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic potential of Aconitum spp. have been scientifically validated for neurological effects on CNS, [4] anti‐proliferative, [5] anti‐microbial, [6] and anti‐rheumatism activity [7] …”

Section: Introductionmentioning

confidence: 99%

Anti‐rheumatic potential vis‐à‐vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India)

Kumar,

Misra,

Rawat

et al. 2024

Chemistry & Biodiversity

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Aconitum spp. are important medicinal plants mentioned in Ayurveda as Ativisa or Vatsanabha. The present study aims to evaluate anti‐rheumatic potential in seven Aconitum species and correlation with aconitine and hypaconitine content. Anti‐rheumatic potential was analyzed through in vitro xanthine oxidase inhibition, anti‐inflammatory and ROS scavenging assays; and quantification of aconitine and hypaconitine with RP‐HPLC method validated as per ICH guidelines. The findings reveal that A. palmatum possessed the most promising response (IC50 = 12.68±0.15 µg/ml) followed by A. ferox (IC50= 12.912±1.87 µg/ml) for xanthin oxidase inhibition. We observed a wide variation in aconitine and hypaconitine content ranging from 0.018%‐1.37% and 0.0051%‐0.077% respectively on dry weight basis. Aconitine and hypaconitine showed moderate positive correlation (r= 0.68 and 0.59 respectively) with anti‐rheumatic potential. The study identifies potential alternative species of Aconitum that can help in sustainable availability of quality raw material.

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Pharmacognostic and phytochemical studies on Ayurvedic drugs Ativisha and Musta

Cited by 21 publications

References 16 publications

Histochemical Screening of Leaves Compared to in situ and in vitro Calluses of Solanum aculeatissimum Jacq.

Histochemical Screening of Leaves Compared to in situ and in vitro Calluses of Solanum aculeatissimum Jacq.

Ciências biológicas: as diversas manifestações da vida

Anti‐rheumatic potential vis‐à‐vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India)

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