Pharmacognostic and physicochemical study of Urtica urens L.: A drug used in Homoeopathy

Patel, Satish; Biswas, Bibaswan; Rambabu, K.; Jhansi, Shyaga; Potu, Ramchander; Sundaram, EN; Arya, Renu

doi:10.4103/ijrh.ijrh_50_18

Cited by 2 publications

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“…Narrative review articles without any research contribution. 7 8 9 10 Book chapters 11 and pharmacognostic and physiochemical studies of drugs for gout and/or hyperuricaemia 12 13 were excluded. The summaries of three types of the included studies are given in Supplementary Table S1 , S2 , and S3 (available in the online version).…”

Section: Methodsmentioning

confidence: 99%

A Systematic Review of Homoeopathic Research on Gout and Hyperuricaemia: Road Ahead

Gautam,

Goel,

Sahoo

2023

Homœopathic Links

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Objective This study aimed to systematically review the literature on homeopathic researches on gout and hyperuricaemia. Materials and Methods A comprehensive online and manual search for research studies on the efficacy of homeopathy in gout and/or hyperuricaemia in clinical trials, in vitro and in vivo experimentation was conducted. All types of studies related to the homeopathic treatment of gout and hyperuricaemia in a human trial, animal experimentations and in vitro experiments on hyperuricaemia, published from January 2001 to January 2022 were considered for review. The methodology was assessed by Jadad scoring for clinical trials, the internal validity of randomised controlled trials by the Cochrane collaboration tool, model validity by Mathie's criteria and the internal validity of observational studies and case reports by the Joanna Briggs Institute (JBI) criteria and JBI appraisal checklist, respectively. Results A total of 16 articles related to homoeopathy on hyperuricaemia and gout were identified, including one preliminary qualitative study, six clinical observational studies, two double-blind, randomised placebo-controlled trials, three case reports, and four animal experiments including one in vitro trial also. Methodological quality analysed by Jaded scoring was diverse, ranging from 0 to 4; by the Cochrane collaboration tool, out of two randomised controlled trials, one had a high risk of bias, while the other had a low risk of bias; observational out of seven studies, only two had a ‘low' risk of bias, three had a ‘moderate' risk and two had a ‘high' risk of bias; JBI appraisal checklist for case report showed two had a ‘low' & one had a ‘moderate' risk of bias. Conclusion This review demonstrates the effectiveness of homoeopathy in all clinical studies, case reports and in vivo and in vitro models studied under the review, but it is difficult to reach a definite conclusion due to a small number of good quality clinical trials, randomised trials and of laboratory experiments.

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Section: Methodsmentioning

confidence: 99%

A Systematic Review of Homoeopathic Research on Gout and Hyperuricaemia: Road Ahead

Gautam,

Goel,

Sahoo

2023

Homœopathic Links

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Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial

Nayak

Pattanaik²,

Chattopadhyay

et al. 2020

Journal of Complementary and Integrative Medicine

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ObjectivesThe quality of management of hyperuricemia has remained sub-optimal owing to unavoidable toxicities, limitations, and dearth of novel advances. Homeopathy has remained under-researched in hyperuricemia. We investigated the clinical effectiveness of three treatment regimens – individualized homeopathy (IH), Urtica urens mother tincture (UUMT), and both (IH + UUMT) along with lifestyle modifications in a sample of 90 patients with hyperuricemia.MethodsAn open, randomized (1:1:1), 3 parallel arms (IH, UUMT, and IH + UUMT), pragmatic trial was conducted at National Institute of Homoeopathy, Kolkata. Outcome measures were serum uric acid (primary), Gout Assessment Questionnaire version 2 (GAQ2, secondary), and Measure Yourself Medical Outcome Profile version 2 (MYMOP2, secondary); all measured at baseline, and after 3 and 6 months. Intention- to-treat sample was analyzed to detect group differences by unpaired t tests.ResultsAttrition rate was 8.9% (IH: 3, UUMT: 3, IH + UUMT: 2). Groups were comparable at baseline. Reductions in serum uric acid over 3 months were comparatively higher (p=0.057) in the UUMT group than others, however, the differences were narrowed over 6 months (p=0.119). Per protocol analysis of serum uric acid level revealed similar trend of significantly higher reduction in the UUMT group than the other two (3 months: p=0.001; 6 months: p=0.007). No significant differences existed in reductions of GAQ2 scores among the three groups. Few significant differences were detected in MYMOP scores over 3 months favoring IH against others (symptom 2, p=0.001 and wellbeing score, p=0.002), and also over 6 months favoring IH + UUMT against others (symptom 1, p<0.001).ConclusionAlthough all three therapies showed similar improvements, the IH + UUMT group had more positive direction of effects than IH or UUMT alone; however, no definite conclusion could be arrived at. Further trials are warranted with larger sample size. Trial registration: CTRI/2018/05/014026.

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Pharmacognostic and physicochemical study of Urtica urens L.: A drug used in Homoeopathy

Cited by 2 publications

References 1 publication

A Systematic Review of Homoeopathic Research on Gout and Hyperuricaemia: Road Ahead

A Systematic Review of Homoeopathic Research on Gout and Hyperuricaemia: Road Ahead

Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial

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