Pharmacognostic and Physicochemical Standardization of Nigella sativa and Allium cepa Seeds

Chachoo, Manzoor Ahmad; Jain, Kirti

doi:10.20510/ukjpb/5/i6/166567

Cited by 4 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…The higher ash values in the flour can be associated with the loss of inorganic material during the extraction with ethanol (Table 3). In general, the ash represents the content of inorganic salts (silicates, oxalates, phosphates) in the plant material, whereas the acid-insoluble ash corresponds to the content of silica and calcium oxalate [21] . The consumption of acid-insoluble ash must be limited since it contributes to renal oxalate deposition (Chaplin 1977).…”

Section: Parameter I3g (Mean) He-es Acceptance Requirementsmentioning

confidence: 99%

“…The organoleptic and physicochemical HE-Es properties could be useful as HE-Es' quality parameters (identity and purity) and to detect adulteration and inadequate manipulation of the plant materials [13,21,25] . The toxicological analyses showed a low total count of bacteria and fungi (Table 3) and absence of pathogenic bacteria (Salmonella spp., Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli) and the analyzed toxins (B1, B2, G1, and G2).…”

Section: Parameter I3g (Mean) He-es Acceptance Requirementsmentioning

confidence: 99%

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Effect of a Standardized Hydroalcoholic Extract of Echeveria subrigida on Mice Glycemia and In Vitro Kinetics of α-Glucosidase Inhibition

-Mercado¹,

-Vargas²,

-Valenzuela³

et al. 2022

IJPS

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Leaf extracts ofEcheveria subrigida show antioxidant, antibacterial, anti-mutagenic, and α-glucosidase inhibitory activities. The inhibitory α-glucosidase is associated with the content of quercetin-3-O-glucoside and isorhametin-3-O-glucoside. The aims of this study were to analyze the effect on mice glycemia and in vitro kinetics of α-glucosidase inhibition of the hydroalcoholic extract of Echeveria subrigida standardized in the content of isorhametin-3-O-glucoside. The high-performance liquid chromatography method was validated to quantitate isorhametin-3-O-glucoside. Hydroalcoholic extract of Echeveria subrigida identity was characterized by its organoleptic, physicochemical, pharmacological and toxicological parameters. The effects on glycemia were carried out in 6 w old male Balb-C mice and using the following treatments; hydroalcoholic extract of Echeveria subrigida at 50, 100 and 200 mg/kg b.w.; positive control glibenclamide or acarbose at 10 mg/kg b.w. The inhibition kinetics of hydroalcoholic extract of Echeveria subrigida was determined by the Lineweaver-Burk plots. Hydroalcoholic extract of Echeveria subrigida had 4.87±0.14 mg isorhametin-3-O-glucoside/g, complied with the World Health Organization parameters for standardized extracts and induced a mixed inhibition on α-glucosidase. Hydroalcoholic extract of Echeveria subrigida (200 mg/kg b.w) and glibenclamide treatments showed similar percent hypoglycemia, 49.1 % and 52 %, respectively. The anti-hyperglycemic assay showed that similar percent reductions in glucose-levels were found in the treatments with hydroalcoholic extract of Echeveria subrigida (100 mg/kg, 29.32 %; 200 mg/kg, 28.99 %) and acarbose (10 mg/kg, 19.87 %). The standardized hydroalcoholic extract of Echeveria subrigida showed hypoglycemic and anti-hyperglycemic activities, stability, and innocuity, suggesting its potential to prevent/treat diabetes mellitus.

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Section: Parameter I3g (Mean) He-es Acceptance Requirementsmentioning

confidence: 99%

Section: Parameter I3g (Mean) He-es Acceptance Requirementsmentioning

confidence: 99%

Effect of a Standardized Hydroalcoholic Extract of Echeveria subrigida on Mice Glycemia and In Vitro Kinetics of α-Glucosidase Inhibition

-Mercado¹,

-Vargas²,

-Valenzuela³

et al. 2022

IJPS

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Microscopic and pharmacognostic standardization ofAstragalus scorpiurusBunge

Uza

Dastagir

2021

Microscopy Res & Technique

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The aim of the current study was to assess and compare the microscopic and pharmacognostic features of the selected parts of Astragalus scorpiurus Bunge. It is an annual and prostrate herb. Anatomy of leaves, stem, and root depicted a typical dicot structure. It will provide information regarding standardization and authentication. The powder drug study (Light Microscopy and Scanning Electron Microscopy) revealed the presence of xylem and phloem vessels, epidermal fragments, cortical cells, fibers, parenchyma tissue, calcium oxalate crystals, nonglandular trichomes, anomocytic stomata, and so on. It will be helpful in identification and quality control.Pollen and seeds micro-morphological features were observed through LM and SEM.These will play a vital role in the taxonomical identification of taxa and provide satisfactory information for taxonomists. Fluorescence analysis revealed different colors under visible and UV light. Extractive values were determined. Powder of the plant parts revealed high extraction in methanol followed by ethanol. Elemental and nutritional profiling were evaluated during two phenological periods that is, vegetative and postflowering period. There were significant phenological variations in mineral and nutritional status of the herb. These parameters are crucial for drug prescription and drug designing. These also provided information regarding nutraceutical and therapeutic value of this herb.

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Black seeds of Nigella sativa: A remedy for advanced cancer therapeutics with special reference to nanotechnology

Ahmad

Imran

Kumar

et al. 2022

Black Seeds (Nigella Sativa)

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Pharmacognostic and Physicochemical Standardization of Nigella sativa and Allium cepa Seeds

Abstract: Standardization is the code of conduct in order to ensure the proper identification, authentication and also for the standardization of crude herbal drugs. The quality of herbal drugs is the sum of all factors which contribute directly or indirectly to the safety,

Cited by 4 publications

References 3 publications

Effect of a Standardized Hydroalcoholic Extract of Echeveria subrigida on Mice Glycemia and In Vitro Kinetics of α-Glucosidase Inhibition

Effect of a Standardized Hydroalcoholic Extract of Echeveria subrigida on Mice Glycemia and In Vitro Kinetics of α-Glucosidase Inhibition

Microscopic and pharmacognostic standardization ofAstragalus scorpiurusBunge

Black seeds of Nigella sativa: A remedy for advanced cancer therapeutics with special reference to nanotechnology

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