Pharmacogenomics of genetic polymorphism within the genes responsible for SARS‐CoV‐2 susceptibility and the drug‐metabolising genes used in treatment

AL-Eitan, Laith N.; Alahmad, Saif Zuhair

doi:10.1002/rmv.2194

Cited by 23 publications

(18 citation statements)

References 101 publications

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“…Além disso, observa-se que há uma diferença nas frequências dos alelos entre as populações (Al-Eitan & Alahmad, 2020). Foi descoberto quatros SNPs no gene TMPRSS2 (rs77675406, rs112657409, rs713400 e rs11910678) que são importantes para que ocorra o processo de infecção desse vírus nos indivíduos (Al-Eitan & Alahmad, 2020).…”

Section: Discussionunclassified

“…Além disso, os pacientes com o genótipo II têm uma chance significativamente maior de sobrevivência do que os pacientes com outros genótipos. A prevalência do genótipo DD é maior em pacientes com infecções pulmonares graves e está significativamente correlacionada com uma alta taxa de mortalidade (Al-Eitan & Alahmad, 2020 (Yamamoto et al, 2020).…”

Section: Variantes Genéticas De Ace1 E Ace2unclassified

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Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2)

Galisa

Almeida

Soares

et al. 2021

RSD

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Este estudo teve como objetivo realizar uma revisão bibliográfica sobre a influência da suscetibilidade genética na incidência e mortalidade de COVID-19. Trata-se de uma revisão descritiva da literatura realizada nas bases de dados PUBMED e Science direct utilizando os seguintes descritores: genetic susceptibility” AND “COVID-19”. Os critérios de inclusão foram artigos científicos disponíveis gratuitamente, nos idiomas inglês, espanhol e português e que foram publicados em 2020. Foram excluídos os artigos duplicados entre as bases. Ao final 58 estudos seguiam os critérios estabelecidos. Os genes ACE2 e TMPRSS2, têm potencial para intervenção profilática e terapêutica nos estágios iniciais de infecção por SARS-CoV-2, desempenhando um papel crucial para a entrada do vírus nas células hospedeiras. Além disso, o lócus do Antígeno Leucocitário Humano (HLA), parece ser crucial para influenciar a suscetibilidade e a gravidade do COVID-19. Indivíduos do sexo masculino apresentam uma maior taxa de mortalidade e de gravidade para a COVID-19, sendo relacionado a uma expressão mais significativa de ACE2 e diferenças na regulação epigenética de ACE2. A suscetibilidade genética pode contribuir para a variabilidade clínica interindividual associada ao COVID-19, permitindo uma avaliação de risco baseada em evidências levando a medidas preventivas personalizadas e opções terapêuticas.

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Section: Discussionunclassified

Section: Variantes Genéticas De Ace1 E Ace2unclassified

Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2)

Galisa

Almeida

Soares

et al. 2021

RSD

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“…Patients with the II genotype have lower mortality in comparison with ID and DD genotypes. In contrast, patients with the DD genotype had severe lung infections and high mortality [69].…”

Section: Host Gene Variability Virus Entry Replication and Antigen Presentationmentioning

confidence: 94%

Host gene variability and SARS-CoV-2 infection: A review article

Kaidashev¹,

Shlykova²,

Измайлова³

et al. 2021

Heliyon

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SARS-CoV-2 is a global threat that influenced healthcare systems around the world. This virus caused an infection in humans with different clinical signs and syndromes, severity, and mortality. The key components of the COVID-19 molecular pathogenesis are coronavirus entry and replication, antigen presentation, humoral and cellular immunity, cytokine storm, coronavirus immune evasion. The analysis of recent literature displayed possible molecular targets in the key components of the COVID-19 pathogenesis. Some of these targets might have gene polymorphisms that influenced the COVID-19 course. Unfortunately, several findings are still putative or extrapolated from SARS and MERS experimental investigations or clinical trials. We systematised original data about gene polymorphisms of possible molecular targets and associations with the COVID-19 course. Most data were obtained for angiotensin-converting enzymes 1 and 2, TMPRSS2 gene polymorphisms. Only a few results were found for gene polymorphisms of adhesion molecules, interferon system components, cytokines, and transcriptional factors, oxidative stress and metabolic molecules, as well as haemocoagulation. Understanding the host gene variability and its associations with COVID-19 can provide insights into the disease pathogenesis, individual susceptibility to SARS-CoV-2 infection, severity, complications, and mortality prognosis for the disease. Besides, these data might help in the identification of appropriate targets for intervention.

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“…First discovered in the 1960s, the coronaviruses (CoV) are a group of enveloped single-stranded RNA viruses with a large genome that can infect different species and cell types [ 102 , 103 ]. Within the past few decades, CoVs have been thrust into the media spotlight after being identified as the cause of a number of lethal diseases in humans.…”

Section: Coronaviruses In the Middle East: Mers-cov And Sars-cov-2mentioning

confidence: 99%

Bat-Borne Coronaviruses in Jordan and Saudi Arabia: A Threat to Public Health?

AL-Eitan

Tarkhan

Alghamdi

et al. 2020

Viruses

Self Cite

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Emerging infectious diseases are of great concern to public health, as highlighted by the ongoing coronavirus disease 2019 (COVID-19) pandemic. Such diseases are of particular danger during mass gathering and mass influx events, as large crowds of people in close proximity to each other creates optimal opportunities for disease transmission. The Hashemite Kingdom of Jordan and the Kingdom of Saudi Arabia are two countries that have witnessed mass gatherings due to the arrival of Syrian refugees and the annual Hajj season. The mass migration of people not only brings exotic diseases to these regions but also brings new diseases back to their own countries, e.g., the outbreak of MERS in South Korea. Many emerging pathogens originate in bats, and more than 30 bat species have been identified in these two countries. Some of those bat species are known to carry viruses that cause deadly diseases in other parts of the world, such as the rabies virus and coronaviruses. However, little is known about bats and the pathogens they carry in Jordan and Saudi Arabia. Here, the importance of enhanced surveillance of bat-borne infections in Jordan and Saudi Arabia is emphasized, promoting the awareness of bat-borne diseases among the general public and building up infrastructure and capability to fill the gaps in public health preparedness to prevent future pandemics.

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Pharmacogenomics of genetic polymorphism within the genes responsible for SARS‐CoV‐2 susceptibility and the drug‐metabolising genes used in treatment

Cited by 23 publications

References 101 publications

Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2)

Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2)

Host gene variability and SARS-CoV-2 infection: A review article

Bat-Borne Coronaviruses in Jordan and Saudi Arabia: A Threat to Public Health?

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