Pharmacogenomics in drug discovery and development

Singh, Baldeep; Jain, Preeti; Devaraja, K; Aggarwal, Sadhna

doi:10.1016/b978-0-443-15336-5.00007-5

Cited by 1 publication

(2 citation statements)

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“…With the recent advent of pharmacogenetics, researchers have been able to quickly identify genetic polymorphisms associated with individual differences in medication sensitivity (see reviews by Evans and Johnson, 2001 ; Singh, 2023 ). Pharmacogenomics is based on the premise that polymorphisms, i.e., differences in the structure of a specific gene or networks of genes, can determine individual differences related to drug metabolism and response.…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacogenomics is based on the premise that polymorphisms, i.e., differences in the structure of a specific gene or networks of genes, can determine individual differences related to drug metabolism and response. Nevertheless, there are issues with healthcare inequalities due to the cost, the underrepresentation of certain groups in genetic databases, as well as issues with data privacy, informed permission and discrimination based on genetic analyses (see review by Singh, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between sensory processing sensitivity and medication sensitivity: brief report

Jagiellowicz,

Acevedo,

Tillmann

et al. 2024

Front. Psychol.

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Sensory processing sensitivity (SPS) is a biological/temperament trait that is associated with greater awareness of and reactivity to the environment, which results in amplified responses to various stimuli, and possibly medications. We investigated the relationship between SPS and medication sensitivity in three studies. Participants (ages 18–81) were recruited from university (Study 1: N = 125; Study 2: N = 214) and online (Study 3: N = 351) samples. In each study, participants completed a medication sensitivity scale, the standard highly sensitive person (HSP) scale to assess SPS, and a negative affectivity (NA) scale as a control variable. All three studies found moderate, significant correlations between SPS and medication sensitivity (r = 0.34, p < 0.001: r = 0.21, p = 0.003; r = 0.36, p < 0.001, respectively). Correlations remained significant, and similar, when controlling for NA and gender; and there were no significant interactions with gender. In sum, our results suggest that SPS is associated with medication sensitivity, even when considering NA and gender. Thus, future work might consider SPS when investigating recommended medication, medication dosage, effectiveness, and adverse drug reactions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%