Pharmacogenomics: From Basic Research to Clinical Implementation

Scheinfeldt, Laura B.

doi:10.3390/jpm11080800

Cited by 2 publications

(1 citation statement)

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“…The recognized influence of genetic differences on the way drugs interact with the body has the capacity to improve the efficiency of medications and lower the risk of adverse drug effects. 1 Drug responses often vary widely among individual patients, not only in terms of positive responses but also adverse drug reactions. 2 The primary objective of effective therapeutics is to match patients with drugs that have a high probability of being effective and causing minimal harm.…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy

Lonah,

Arieselia,

Setiawan

et al. 2023

j. urban health res.

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The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450

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Section: Introductionmentioning

confidence: 99%