2021
DOI: 10.1016/j.neuron.2021.09.011
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Pharmacogenomics: A road ahead for precision medicine in psychiatry

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Cited by 32 publications
(34 citation statements)
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References 202 publications
(244 reference statements)
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“…Individual differences in response to psychopharmacology are known to be influenced by genetic and environmental factors (7,8). Pharmacogenomics research aims to identify genetic variants that contribute to this variability and is one of the most promising pillars of precision medicine strategies (9).…”
Section: Introductionmentioning
confidence: 99%
“…Individual differences in response to psychopharmacology are known to be influenced by genetic and environmental factors (7,8). Pharmacogenomics research aims to identify genetic variants that contribute to this variability and is one of the most promising pillars of precision medicine strategies (9).…”
Section: Introductionmentioning
confidence: 99%
“…Individual differences in response to pharmacological treatment are known to be influenced by genetic and environmental factors (8,9). Pharmacogenomic research aims to identify genetic variants that contribute to this variability and is one of the most promising pillars of precision medicine strategies (10). To date, while most known pharmacogenomic variants are associated with ADME processes (absorption, distribution, metabolism, and excretion), markers associated with disease and disorder risk can also be assessed to investigate treatment outcomes (11).…”
Section: Introductionmentioning
confidence: 99%
“…This suggests that investigating the association between genetic liability to the disorder and response to antipsychotics might be fruitful, with a hypothesis being that heavier genetic burden could be associated with poorer treatment response. As treatment outcomes in schizophrenia are multifaceted and depend on complex factors including treatment adherence (10), many studies on this matter have investigated treatment response by focusing on individuals with the most severe symptomatology, often using samples of those with TRS (16). However, the evidence for schizophrenia risk alleles being predictors of TRS is inconclusive, and the largest study on this topic suggests that the schizophrenia PRS is not substantially elevated in those with this diagnosis (17).…”
Section: Introductionmentioning
confidence: 99%
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“…Recent genome-wide association studies (GWAS) have pointed towards a small number of variants that could explain between 1% and 10% of the variance in clozapine pharmacokinetics after accounting for non-genetic factors 14,15 , and these may also have downstream relevance for ADRs 16 . Unfortunately, these studies have only been carried out in individuals of European ancestry, a clear limitation given the known diversity of drug-metabolising enzyme alleles worldwide, and the potential lack of transferability of genomic predictors across populations 13 . The Eurocentrism of clozapine pharmacogenomics studies is also particularly problematic as the prescription patterns and outcomes of this drug seem to be ancestrally stratified to some extent: For example, doses recommended for individuals of East Asian ancestry and indigenous populations of the Americas are lower than those typically prescribed to Europeans, to compensate for a generally slower clozapine metabolism in those populations 17 .…”
Section: Introductionmentioning
confidence: 99%