Pharmacogenetics: The Scientific Basis

Banjoko, Bosun

doi:10.5772/25900

Cited by 1 publication

(4 citation statements)

References 62 publications

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“…Genetics is the study concerned with hereditary and variation [1]. One in all the foremost fundamental properties of all living organisms is that the ability to reproduce.…”

Section: Geneticsmentioning

confidence: 99%

“…Variation in drug metabolism and drug response among individuals of the identical weight and on the identical drug dose is because of temporary causes like transient enzyme inhibition, induction or permanent causes like genetic mutation, gene deletion or amplification [1].…”

Section: Variationmentioning

confidence: 99%

“…The underpinning factors for the growing importance of pharmacogenetics are the need to stop adverse drug reaction, obtain maximum benefits from drug therapy and reduce therapeutic failure [1].…”

Section: Consequencesmentioning

confidence: 99%

“…The history of genetic variations in drug responses is traced to the 1950s with the observations that relaxant suxamethonium chloride and medicines metabolized by Nacetyl transferase exhibit differences in response in patients [1]. One in 3500 caucasians was found to possess the less efficient variant of the enzyme, butyryl chlolinesterase that metabolizes suxamethonium chloride; an anesthetic.…”

Section: Introductionmentioning

confidence: 99%

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A Few Words about Pharmacogenetics

Franjić¹

2022

JCMR

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Pharmacogenetics deals with genetically determined variations in response to drugs. Pharmacogenetics studies interindividual differences in DNA sequence that lead to a variable response to drug therapy. The ultimate goal of pharmacogenetics is to establish treatment on the principles of the personalized medicine in which each person, ie patient, is approached as an individual. The way to achieve this is to use molecular diagnostic methods to determine the pharmacogenetic status of the patient and to provide the possibility of adjusting the treatment to his needs.

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“…Genetics is the study concerned with hereditary and variation [1]. One in all the foremost fundamental properties of all living organisms is that the ability to reproduce.…”

Section: Geneticsmentioning

confidence: 99%

Section: Variationmentioning

confidence: 99%

Section: Consequencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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