Pharmacogenetics of methotrexate in rheumatoid arthritis: A systematic review

Restrepo, Luisa F.; Giraldo, Rodrigo; Londoño, John; Pinzón, Carlos; Cortes, Ani; Ballesteros, G.; Santos, Ana Maria Ribeiro dos

doi:10.1016/j.rcreue.2016.08.002

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…An increasing number of SNPs have been found to be possibly associated with the efficacy and toxicity of MTX. The newly discovered genotypes include C347G in ATIC and 5′-UTR 28-bp repeat and 3′-UTR 6-bp deletion in TYMS, which may influence both efficacy and toxicity of MTX; similarly, factors that may affect MTX associated toxicity are, for example, A2756G in MS and A66G in MTRR [ 29 , 39 , 45 , 46 ]. The genes and their SNPs that might be associated with the effects and side effects of MTX are summarized in Table 1 .…”

Section: The Pharmacogenetics Of Mtxmentioning

confidence: 99%

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A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

Wang

Peng

2020

Journal of Ophthalmology

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Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. There is no comparatively systematic review on MTX associated side effects and its risk factors. This review aimed to reveal novel clinical approaches of MTX and its adverse effects in order to provide a reference for ophthalmic scholars in clinical application of MTX.

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Section: The Pharmacogenetics Of Mtxmentioning

confidence: 99%

“…To prevent MTX associated side effects, it is common to take folate [as either folic acid (FA) or folinic acid (FLA)] in clinic [ 46 , 105 , 106 ]. However, there is no consistent and evidence-based guideline for folate supplementation in ophthalmic patients.…”

Section: The Side Effects Of Mtxmentioning

confidence: 99%

A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

Wang

Peng

2020

Journal of Ophthalmology

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“…Respons terhadap metotreksat sangat bervariasi di antara pasien. 4 Penelitian-penelitian sebelumnya memberikan kesimpulan yang masih diperdebatkan berkaitan dengan prediktor terjadinya remisi pada pasien AR yang diterapi dengan DMARD. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang berhubungan dengan remisi pada pasien AR.…”

Section: Pendahuluanunclassified

Hubungan Antara Parameter Klinis Dan Laboratoris Dengan Status Remisi Penyakit Pada Pasien Artritis Reumatoid Yang Mendapat Terapi Metotreksat

Suryana

Sari

Tamayanti

et al. 2019

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Artritis reumatoid (AR) adalah penyakit autoimun yang etiologinya belum diketahui. Metotreksat adalah DMARD (disease-modifying antirheumatic drug) yang paling sering digunakan pada AR, namun respons terhadap metotreksat bervariasi di antara populasi. Data mengenai faktor klinis dan laboratoris yang berhubungan dengan remisi pada AR yang diterapi dengan metotreksat masih tidak konsisten. Penelitian ini bertujuan untuk mengetahui faktor-faktor klinis dan laboratoris yang berhubungan dengan remisi pada pasien AR yang mendapat terapi metotreksat. Data diperoleh dari pasien AR yang memenuhi kriteria ACR-EULAR 2010 dengan desain penelitian observasional dan pendekatan potong lintang. Data meliputi jenis kelamin, usia onset penyakit, durasi penyakit, indeks masa tubuh (IMT), tender joint count (TJC), swollen joint count (SJC), visual analog scale (VAS) nyeri, disease activity score (DAS)-28 awal, laju endap darah (LED), anti-cyclic citrullinated protein (CCP), dan rheumatoid factor (RF). Variabel dianalisis secara statistik dengan uji chi square dilanjutkan regresi logistik multipel. Penelitian ini melibatkan 88 pasien AR, terdiri dari 85,2% wanita (n = 75) dan 14,8% pria (n = 13), rerata usia 54,78±11,34. Proporsi remisi pasien adalah 26,1%. Dari analisis bivariat dengan uji chi square didapatkan variabel yang berhubungan bermakna terhadap remisi, yaitu usia onset (p = 0,037), VAS nyeri (p = 0,030) dan LED (p = 0,038). Dapat disimpulkan bahwa usia onset, VAS nyeri, dan LED berhubungan bermakna dengan remisi penyakit pasien AR yang diterapi dengan metotreksat.

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Polymorphisms for the Clinical Efficacy and Toxicity of Methotrexate in Patients with Rheumatoid Arthritis: Systemic Review

Alharthi,

Magadmi,

Jamal

2024

International J. of Pharmacology

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Pharmacogenetics of methotrexate in rheumatoid arthritis: A systematic review

Cited by 4 publications

References 55 publications

A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

Hubungan Antara Parameter Klinis Dan Laboratoris Dengan Status Remisi Penyakit Pada Pasien Artritis Reumatoid Yang Mendapat Terapi Metotreksat

Polymorphisms for the Clinical Efficacy and Toxicity of Methotrexate in Patients with Rheumatoid Arthritis: Systemic Review

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