Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission

Nudmamud-Thanoi, Sutisa; Iamjan, Sri-arun; Kerdsan-Phusan, Walailuk; Thanoi, Samur

doi:10.1016/j.neulet.2019.02.046

Cited by 1 publication

(2 citation statements)

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“…Moreover, a significant association between an SLC1A2 SNP, the synonymous G603 A (rs752949) in exon 5, has also suggested the susceptibility of this gene to risk-taking behaviour in alcohol dependence. These findings provide evidence to support the involvement of the EAAT2 gene in aspects of drug dependence [ 17 ]. Additionally, SLC1A2 polymorphism was shown to significantly influence other mental health disorders related to the total episode recurrence rate in bipolar disorders, with G homozygotes reporting the highest number ( p = 0.004) [ 26 ].…”

Section: Discussionmentioning

confidence: 58%

“…Recently, Veldic et al (2019) discovered that the SLC1A2 gene is associated with a higher risk of pathological conditions related to changes in the extracellular glutamate levels [ 16 ]. Indeed, the SLC1A2 gene is considered a strong candidate for drug dependence and associated psychosis since its variants are hypothesized to be associated with schizophrenia, and schizophrenia’s symptoms, including paranoid hallucinations and delusions, resemble drug-induced psychosis [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis

Yahya

Guad

et al. 2023

JPM

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SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype.

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Section: Discussionmentioning

confidence: 58%