Pharmacogenetics of aminoglycoside-related ototoxicity: a systematic review
D Gaafar,
N Baxter,
N Cranswick
et al.
Abstract:Background
Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the development of ototoxicity.
Objectives
To evaluate the pharmacogenetic determinants of AG-related ototoxicity.
Methods
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