Pharmacogenetics: implications for obstetric anesthesia

Landau, Ruth

doi:10.1016/j.ijoa.2005.03.005

Cited by 11 publications

(5 citation statements)

References 81 publications

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“…The greatest contribution to propofol’s individual response is seen in the variants of the CYP2C9 , CYP2B6 , UGT1A9 , SULT1A1 , NQO1 genes, involved in the biotransformation pathway of the anaesthestic and also of transporting proteins: especially P-glycoprotein and serum albumin, encoded by the ABCB1 and ALB genes, as well as the receptor genes GABRA1 and ADRA1A 4 , 9 , 10 . The crucial role can be probably played by three of the genes mentioned above: CYP2B6 (OMIM123930), CYP2C9 (OMIM601130) and UGT1A9 (OMIM606434), coding for metabolizing enzymes: cytochromes P-450 2B6 and 2C9, and UDP-glucuronosyltransferase 1A9, acting mainly in the liver.…”

Section: Introductionmentioning

confidence: 99%

“…proved the correlation between mutation p.M236W in the GABRA1 gene and the influence of etomidat anaesthetic on the receptor 22 . Moreover, studies have shown that polymorphism of the adrenergic receptor gene ( ADRA1A , OMIM104221) influences the expression of these proteins, the post-translational processes and pharmacological response by the receptor interfering with the signal transduction, what may change the regulation of a number of relevant parameters in anaesthesia 9 .…”

Section: Introductionmentioning

confidence: 99%

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Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia

Zakerska-Banaszak

Skrzypczak-Zielińska

Tamowicz

et al. 2017

Sci Rep

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The individual response of patients to propofol results from the influence of genetic factors. However, the state of knowledge in this matter still remains insufficient. The aim of our study was to determine genetic predictors of variable pharmacokinetics and pharmacodynamics of propofol within selected 9 genes coding for propofol biotransformation enzymes, receptors and transporters. Our studies are the first extensive pharmaocgenetics research of propofol using high throughput sequencing technology. After the design and optimization of long range PCR-based next-generation sequencing experiment, we screened promoter and coding sequences of all genes analyzed among 87 Polish patients undergoing general anaesthesia with propofol. Initially we found that two variants, c.516 G > T in the CYP2B6 gene and c.2677 T > G in the ABCB1 gene, significantly correlate with propofol’s metabolic profile, however after Bonferroni correction the P-values were not statistically significant. Our results suggest, that variants within the CYP2B6 and ABCB1 genes correlate stronger with propofol’s metabolic profile compared to other 7 genes. CYP2B6 and ABCB1 variants can play a potentially important role in response to this anaesthetic and they are promising object for further studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia

Zakerska-Banaszak

Skrzypczak-Zielińska

Tamowicz

et al. 2017

Sci Rep

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“…Carriers with two null alleles in the CYP2D6 gene or a combination of one null allele with a second allele with reduced function are characterized by reduced or completely absent enzymatic activity of the 2D6 isoenzyme (5-10% of Europeans). These patients are characterized by rapid accumulation of narcotic analgesic, and they need to prescribe lower doses [17].…”

Section: P H a R M A C O G E N E T I C S : R E L E V A N C E F O R T mentioning

confidence: 99%

THESIGNIFICANCE OF PHARMACOGENETIC TESTING FOR BETTER ANAESTHETIC OUTCOME AND LESSSURGICALSTRESS. Literature Review

Татжикова¹,

Кантемирова²,

Жидовинов³

et al. 2020

AREM

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The review is devoted to the problem of optimizing the anesthetic manual based on pharmacogenetic data in order to achieve an adequate depth of anesthesia and stress protection and reduce the number of adverse drug reactions. We analyzed the data of Pub Med and Web of Science databases to investigate the influence of genetic polymorphism on the body's response to the main groups of drugs used for anesthesia, and changes in the effects of drug interaction. Specifically, we have reported that the use of preoperative genetic screening for a set of markers (polymorphic alleles of a number of cytochromes) is a promising tool in the anesthesiologist's practice.

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“…Genetic variability is seen in both the pharmacodynamics (i.e., the opioid receptors) and the pharmacokinetics (i.e., metabolism) of opioids. [20] A mutation in the μ-opioid receptor (A118G) exhibits greater binding and potency of β-endorphins to the receptor. This genetic polymorphism exists at a much higher rate in the South East Asian population (35-47%) compared to the Caucasian population (11.5%).…”

Section: Opioidsmentioning

confidence: 99%

Postoperative analgesia for gynecological laparoscopy

Gibbison

Kinsella

2009

Saudi J Anaesth

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Gynecological laparoscopy is a commonly performed procedure. Providing anesthesia for this can present a challenge, particularly in the day surgery population. Poor analgesia, nausea, and vomiting can cause distress to the patient and increased cost for the health system, because of overnight admission. In this review we discuss anesthetic and analgesic techniques for day-case gynecological laparoscopy. The principles include multimodal analgesia, the use of the oral route wherever possible, and the contribution of the surgeon.

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Pharmacogenetics: implications for obstetric anesthesia

Cited by 11 publications

References 81 publications

Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia

Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia

THESIGNIFICANCE OF PHARMACOGENETIC TESTING FOR BETTER ANAESTHETIC OUTCOME AND LESSSURGICALSTRESS. Literature Review

Postoperative analgesia for gynecological laparoscopy

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