Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough

Mas, Sergi; Gassó, Patricia; Álvarez, Santiago; Ortiz, Jacint; Sotoca, JM; Francino, Antonio; Carné, Xavier; Lafuente, Amàlia

doi:10.1097/fpc.0b013e328348c6db

Cited by 50 publications

(46 citation statements)

References 24 publications

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“…[13][14][15] The evidence of ABO rs495828 functionality found here further supports associations previous published between this polymorphism and different traits. [9][10][11][12] The main limitation of this study is the small sample size. Taking this into account we cannot rule out that rs495828 may be involved, at least in part, in determining ACE activity.…”

Section: Discussionmentioning

confidence: 96%

“…9,10 While the T allele was found to be a protection factor for hypertension, the same allele was a risk factor for the cough in patients treated with ACEI. If the T allele gives rise to lower ACE activity, it could lead to lower risk of hypertension and higher bradykinin levels thus triggering the cough in patients treated with ACEI, which would fit with our previous results perfectly (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity

Gassó

Ritter

Mas

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction: ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied. Subjects and methods: We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age-and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8). Results: A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029). Conclusion: These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity

Gassó

Ritter

Mas

et al. 2014

J Renin Angiotensin Aldosterone Syst

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“…Several candidate gene studies [5][6][7][8][9][10] have been carried out to identify the association between polymorphisms and cough, but no genes have been confirmed to predispose to ACEI-induced cough [11][12][13]. Candidate genes are usually selected according to the pathogenic mechanism.…”

Section: Introductionmentioning

confidence: 99%

Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension

Luo

et al. 2014

Pharmacogenetics and Genomics

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“…Second, cases were recruited to participate in a pharmacogenetic study of ACE inhibitors. 13 For this reason, all cases were being treated with this antihypertensive drug. Thus, our group of cases could represent a clinical subgroup of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…12 In a previous study, we associated the minor allele of the rs495828 polymorphism of the ABO gene with the incidence of cough induced by treatment with ACE inhibitors in females (P¼6.0Â10 À4 ). 13 According to the hypothesis that ACE activity could be an important marker of hypertension risk, our objective is the identification of genetic polymorphisms associated with hypertension risk that are related to this quantitative trait. As several polymorphisms in the ACE gene have been related to the level of ACE activity in different populations, we included a complete analysis of genetic variability of the ACE gene, using an extensive LD mapping approach with haplotype-tagging single-nucleotide polymorphisms (SNPs) selected from HapMap data for this gene.…”

Section: Introductionmentioning

confidence: 99%

A common variant of the ABO gene protects against hypertension in a Spanish population

et al. 2012

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The objective of this study was to establish whether genetic polymorphisms that could be related to angiotensin-converting enzyme (ACE) levels are associated with hypertension. A total of 10 haplotype-tagging single-nucleotide polymorphisms in ACE, the ACE I/D polymorphism, and 2 polymorphisms in the ABO (rs495828 and rs8176746) were investigated for association with hypertension in 269 hypertensive patients and 254 healthy controls. All analyses were adjusted for age and body mass index, and corrected for multiple testing. Only one polymorphism of the ABO gene (rs495828) presented nominal pointwise Po0.05 values (odds ratio¼0.33, 95% CI 0.19-0.58, P¼6Â10 À5 ) and achieved Po3.8Â10 À3 , the nominal P-value considered significant after Bonferroni correction. Analysis of the genotype frequencies showed that the model that correctly explained the observed association was the recessive model (odds ratio¼0.03, 95% CI 0.01-0.15, P¼1Â10 À6 ). These results indicate that genetic variants that could be related to ACE activity are good predictors of hypertension, and identify ABO as a good candidate gene for genetic studies of hypertension risk. Further studies are required to confirm this association.

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Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough

Cited by 50 publications

References 24 publications

Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity

Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity

Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension

A common variant of the ABO gene protects against hypertension in a Spanish population

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