Pharmacoengineering of Lipid Nanoarchitectonics in Modulating Particle Uptake by Lung Macrophages

Thalla, Maharshi; Banerjee, Subham

doi:10.1002/9783527832095.ch12

Cited by 2 publications

(1 citation statement)

References 158 publications

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“…Lastly, regulatory considerations will also play a crucial role in the future of lipid nanoparticles [66]. As these systems become more complex and multifunctional, regulatory bodies will need to adapt their guidelines to ensure safety and efficacy [66][67][68][69][70][71].…”

Section: Future Directionmentioning

confidence: 99%

Lipid-based nanoparticles and their recent advances

Onteru Sujeevan

2024

GSC Adv. Res. Rev.

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Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may arise, lipid nanoparticles offer numerous benefits for loading biomolecules, improving pharmacokinetics, and enhancing therapeutic effects. It is important to address stability and loading challenges when encapsulating biomolecules and consider potential immunogenic responses that may impact biocompatibility and safety.

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