Pharmacodynamics assessment of β-carboline from the roots of Psammosilene tunicoides as analgesic compound

Hou, Yanming; Dong, Bangjian; Peng, Ying; Peng, Cheng; Wang, Mengyue; Li, Xiaobo

doi:10.1016/j.jep.2022.115163

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…Beta-carbolines in general have been shown to have very interesting chemical characteristics including optoelectronic properties, potential as anti-cancer agents, and many other bioactivities [77][78][79][80] . Specifically, the molecules formed through the Mcb pathway in Marinactinospora thermotolerans have been shown to have antimalarial, cytotoxic, and anti-inflammatory activities 81,82 . TsrM catalyzes the reaction to 2-methyl-L-tryptophan via a unique cobalamin-dependent radical SAM mechanism and is the first step towards the synthesis of the antibiotic thiostrepton A [83][84][85] .…”

Section: Initial Halogen-product Diversification Through Complementin...mentioning

confidence: 99%

A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules

Reed,

Brooks,

Wells

et al. 2024

Nat Commun

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Halogen-containing molecules are ubiquitous in modern society and present unique chemical possibilities. As a whole, de novo fermentation and synthetic pathway construction for these molecules remain relatively underexplored and could unlock molecules with exciting new applications in industries ranging from textiles to agrochemicals to pharmaceuticals. Here, we report a mix-and-match co-culture platform to de novo generate a large array of halogenated tryptophan derivatives in Escherichia coli from glucose. First, we engineer E. coli to produce between 300 and 700 mg/L of six different halogenated tryptophan precursors. Second, we harness the native promiscuity of multiple downstream enzymes to access unexplored regions of metabolism. Finally, through modular co-culture fermentations, we demonstrate a plug-and-play bioproduction platform, culminating in the generation of 26 distinct halogenated molecules produced de novo including precursors to prodrugs 4-chloro- and 4-bromo-kynurenine and new-to-nature halogenated beta carbolines.

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Section: Initial Halogen-product Diversification Through Complementin...mentioning

confidence: 99%

A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules

Reed,

Brooks,

Wells

et al. 2024

Nat Commun

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“…[2] β-Carboline scaffold is distributed widely in nature. Examples include seeds [3] and fruits [4] of Peganum harmala L, roots of Psammosilene tunicoides, [5] Evodiae fructus herb, [6] Picrasma quassioides, [7] Vochysia divergens, [8] marine sponge Hyritos reticulatus, [9] marine tunicate Cnemidocarpa stolonifera, [10] and marine bryozoan Pterocella vesiculosa. [11] Owing to their important biological activities, [12] many of these alkaloids were also prepared synthetically.…”

Section: Introductionmentioning

confidence: 99%

The Progress in Pictet‐Spengler β‐Carboline Synthesis under Green Conditions

Mousa,

Adly,

Mahmoud

et al. 2024

ChemistrySelect

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Abstractβ‐Carboline ring is widely distributed in nature and several β‐carboline alkaloids were extracted from marine creatures, bacteria, fungi, food stuffs, plants, and mammals. Synthetic β‐carbolines derivatives were reported to exhibit various biological activities. This review highlighted the recent progress achieved in the last decade in the Pictet‐Spengler synthesis of β‐carboline derivatives with a special focus on the green methods and green catalysts used for the synthesis.

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Pharmacodynamics assessment of β-carboline from the roots of Psammosilene tunicoides as analgesic compound

Cited by 2 publications

References 42 publications

A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules

A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules

The Progress in Pictet‐Spengler β‐Carboline Synthesis under Green Conditions

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