Pharmacodynamic studies on the isolated active fraction of Acacia farnesiana (L.) willd

Kingsley, Bino; Kayarohanam, Saminathan; Brindha, P.; Subramoniam, A.

doi:10.4103/0973-1296.133277

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…In third tube which called (extract) the level of utilized glucose from the media is 14%. In fourth tube which called (mixture) the level of utilized of glucose from the media is 69.4% significantly increased glucose uptake by isolated rat diaphragm as compared to control, that agree with previous study which used Acacia farnesiana (L.) extract the isolated hemidiaphragm, glucose uptake was increased by treatment at 40 μg/ml of extract [24].…”

Section: Discussionsupporting

confidence: 88%

“…In comparison with the group which treated the plant extract at dose 400mg\kg showed mordent decrease in the blood glucose level of diabetic rats to 96-123at the time interval 2,4h respectively. the group which treated the plant extract at dose 200mg\kg given least in blood glucose level of diabetic rats to 100.2-114 at the time interval 2,4h respectively, this compatible with the other studies which used extract from different species of Acacia; Acacia farnesiana (L.) willd water extract at a dose of 50 mg/kg showed significant glucose lowering activity at 30 and 90 min after glucose loading in normal fed rats [24]. Study by Rahmatullah M[25] which used Acacia catechu prepared from boiling the wood in water the different doses of extract was administered.…”

Section: Discussionsupporting

confidence: 83%

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The Effect of Ethanolic Extract of Acacia Seyal Bark on Induced Diabetic rats

Elhasan

Ahmed²,

Abdelgadir

et al. 2022

Preprint

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Background: Diabetes mellitus Type 2 is a chronic metabolic disorder characterized by insulin insensitivity that leads to a decrease in glucose transport into the other cells. Many drugs are being developed, while no cure is available regarding to this disease although, there are limitations due to high cost and certain side effects. The Traditional Medicines are preferred due to lesser side effects and low cost. Acacia species have wide traditional medicinal using as anti-diabetic, antimicrobial, and anti-inflammatory activities. Objective: The study aimed to examine the effect of ethanolic extract of Acacia Seyal bark in induced diabetic rats. Materials and methods: Acacia Seyal bark was extracted in ethanol 80%. The Ethanolic extract was analyzed for phytochemicals screening tests using standard methods. To investigate the effect of the extract thirty induced diabetic albino rats introduced by injection of glucose 2g\kg were divided to 5 groups equally; Group 1 was treated with 10mg\kg of glibenclamide, group 2 left as control treated with distilled water 10mg\kg, Group 3 was treated with 200mg of plant extract, Group 4 was treated with 400mg of plant extract, and Group 5 was treated with 800mg of plant extract. The Glucose Tolerant Test were done after 1 hour, 2 hour and 4 hour to determine blood glucose level of rats. Estimation of in vitro glucose uptake by rat diaphragm experiment was done to evaluate the glucose utilization capacity of extract. Results: The effect of different concentration of ethanolic extract of Acacia Seyal bark on the blood glucose level of diabetic induced rats is significantly different (0.05 p 0.01 <p). The phytochemical screening of extract indicated the presence of Saponin, Tannins Steroids, Triterpens, and Anthraquinone, While the absence of flavonoids. In vitro glucose consumption by diaphragm study the level of utilized glucose from the media is 69.4% in the presence of extract compared to control group. Conclusion: Study concluded that the ethanolic bark extract of A. seyal showed significant anti-diabetic activity. This results might have a great potential for translation to humans and the obtained data might set the stage for clinical trials investigating the effects of anti-diabetic effect in patients with diabetes mellitus type2. In the best of our knowledge, this is the first study that has conducted to study the anti-diabetics effect of ethanolic extract of Acacia Seyal bark in diabetic rats. Key words: Acacia Seyal Bark, Diabetes mellitus type 2, Ethanolic extract, Anti diabetic activity, Phytochemical screening. Glucose Tolerance Test.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 83%

The Effect of Ethanolic Extract of Acacia Seyal Bark on Induced Diabetic rats

Elhasan

Ahmed²,

Abdelgadir

et al. 2022

Preprint

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“…In addition, several species of this genus are used as ornamental lumberyard, in tanneries due to the presence of tannins, for extraction of gums. Its flower essences are used in perfumery, fixing dunes, and formation of hedges (Ramli et al, 2011;Kingsley et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Morphological analysis of fruits, seeds, and seedling germination Acacia farnesiana (L.) Willd

Melo¹,

Silva²,

Alves³

et al. 2016

Afr. J. Agric. Res.

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The understanding of the morphology of fruits, seeds and seedlings is very important on the identification and the preservation of species. The work describes and illustrates morphological characteristics of fruits, seeds, germination, and seedlings of Acasia farnesiana. The fruits were collected manually from parent trees selected at random, in the municipality of Sousa State of Paraíba. After collection, they were packed in polyethylene bags and taken to the Seed Analysis Laboratory, Universidade Federal da Paraiba, Areia-PB. Subsequently, evaluations were made of the morphological and morphometric characteristics of fruit, seed germination stages, and seedling. The fruit is of type nucule vegetable, plain, dry, polysemy, glabrous, linear-format wavy and late dehiscence. The seeds are stenospermics, format obovoid, apex rounded, and base slightly rounded. The germination is epigealphanerocotyledonal, starting on the third day and may be terminated on the seventh day after sowing. It was possible to describe and illustrate in detail the morphology of fruit, seeds, germination stages, and seedling of the species, considering the characteristics of easy recognition, standardization, rapid achievement, and high probability of establishment in the field.

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“…This species is an important option for recovery of degraded pastures, whilst its fruits can be used for animal feeding (Erkovan et al, 2013) and its leaves can be explored due to its antifungal properties and for phytotherapy medicines production (Kingsley et al, 2014).…”

mentioning

confidence: 99%

Temperature and pre-germinative treatments for overcoming Acacia farnesiana (L.) Willd. (Fabaceae) seeds dormancy

Paulo¹,

Edna²,

Antonio³

et al. 2016

Afr. J. Agric. Res.

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Acacia farnesiana L. is a species known for its uses in recovery of degraded pastures, animal feeding, medical and fungicide properties. However, it is one of the most problematic invasive species in agriculture, due to the little known dormancy aspects of its seeds that results in the propagation and dispersion to distinct areas and the establishment of the invasive plant. The knowledge on ecophysiological characteristics of invasive species seeds aiming at the dormancy process is important for the comprehension of aggressive regeneration unities, and allows the development of strategies against infestation of new areas and reduction of soil seed banks. The objective of this research was to assess how A. farnesiana seeds overcome dormancy using different temperatures and pre-germinative treatments. The study was conducted in Federal University of Paraiba, using seeds obtained from fruits of ten matrix trees in Paraiba State, Brazil. The completely randomized design was adopted, with treatments arranged in a 3 x 15 factorial scheme representing temperatures and pregerminative treatments with four replicates. Parameters related to germination percentage, germination and emergency index were assessed, with best results observed in seeds scarified with sandpaper 80 followed by imbibitions of water at environmental temperature (25-30°C) for 24 h.

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Pharmacodynamic studies on the isolated active fraction of Acacia farnesiana (L.) willd

Cited by 4 publications

References 13 publications

The Effect of Ethanolic Extract of Acacia Seyal Bark on Induced Diabetic rats

The Effect of Ethanolic Extract of Acacia Seyal Bark on Induced Diabetic rats

Morphological analysis of fruits, seeds, and seedling germination Acacia farnesiana (L.) Willd

Temperature and pre-germinative treatments for overcoming Acacia farnesiana (L.) Willd. (Fabaceae) seeds dormancy

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