Pharmacodynamic interaction of the sedative effects of Ternstroemia pringlei (Rose) Standl. with six central nervous system depressant drugs in mice

Balderas, José Luis; Reza, Victoria; Ugalde, M.; Hernández‐Guzmán, Laura; Serrano, Miriam Isabel; Aguilar, Abigaı́l; Navarrete, Andrés

doi:10.1016/j.jep.2008.05.035

Cited by 13 publications

(7 citation statements)

References 27 publications

(49 reference statements)

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“…tested the sedative effect of an aqueous extract of the dried fruits of Ternstroemia pringlei (rose) in synergy with 6 CNS depressant drugs and found that the aqueous extract can induce a sedative effect in a dose-dependent manner and potentiate the sedative effect of buspirone, diazepam, diphenhydramine, haloperidol or pentobarbital and produce an attenuation of the sedative effect of ethanol. They believe that this plant has hard non-predictive interactions with CNS depressant drugs; thereafter the combination of this plant with CNS depressant drugs should be avoided [80]. However, other researchers have reported different issues, such as super-additive interactions, which imply us further studies are still needed to confirm the drug interactions and other side effects of Ternstroemia pringlei before it becomes an recommended treatment for insomnia.…”

Section: Resultsmentioning

confidence: 99%

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

Shi¹,

Dong²,

Zhao³

et al. 2014

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Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the γ-aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects, numerous studies focusing on the neurotransmitter GABA and herbal medicines have been conducted. Traditional herbal medicines, such as Piper methysticum and the seed of Zizyphus jujuba Mill var. spinosa, have been widely reported to improve sleep and other mental disorders. These herbal medicines have been applied for many years in folk medicine, and extracts of these medicines have been used to study their pharmacological actions and mechanisms. Although effective and relatively safe, natural plant products have some side effects, such as hepatotoxicity and skin reactions effects of Piper methysticum. In addition, there are insufficient evidences to certify the safety of most traditional herbal medicine. In this review, we provide an overview of the current state of knowledge regarding a variety of natural plant products that are commonly used to treat insomnia to facilitate future studies.

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Section: Resultsmentioning

confidence: 99%

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

Shi¹,

Dong²,

Zhao³

et al. 2014

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“…The gastroprotection exerts by natural products and crude extract mixtures in the traditional medicine plays an important role, because the mix of traditional herbal remedies is frequently used in several countries, mainly for the treatment of gastrointestinal diseases (Farzaei et al, ; Schmeda‐Hirschmann & Yesilada, ). In the evaluation of newly isolated compounds, the interaction studies are an important aspect to evaluate, especially in those with a pharmaceutical potential (Balderas et al, ; Ugalde et al, ). Nonetheless, few studies have evaluated natural product‐natural product interactions, especially in those that come from plants with an important traditional use (Navarrete et al, ; Rodríguez‐Ramos et al, ; Ugalde et al, ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic interaction of 3α‐hydroxymasticadienonic acid and diligustilide against indomethacin‐induced gastric damage in rats

Pineda-Peña

Meza-Pérez

Chávez-Piña

et al. 2019

Drug Development Research

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The aims of the study were to evaluate the pharmacodynamic interaction between 3α-hydroxymasticadienonic acid and diligustilide (DLG), isolated from the plants Amphiptherygium adstringens and Ligusticum porteri, respectively, using the indomethacininduced gastric injury model, as well as their individual gastroprotective efficacy in this model. Male Wistar rats were orally administered with 3α-hydroxymasticadienonic acid, DLG or the mixture of 3α-hydroxymasticadienonic acid-DLG (at a fixed-ratio combination of 1:1, 1:3, and 3:1). Thirty minutes later, the gastric damage was induced by a single oral dose of indomethacin (30 mg/kg). Three hours later, the gastric injury (mm 2 ) was determined. 3α-hydroxymasticadienonic acid and DLG as individual compounds showed a gastroprotective effect against indomethacin-induced gastric damage (p < .05).The effective dose (ED 50 ) values for each compound were 6.96 ± 1.25 mg/kg for 3α-hydroxymasticadienonic acid and 2.63 ± 0.37 mg/kg for DLG. The isobolographic analysis performed showed that the combination exhibited super-additive interaction as the experimental ED 50 values (Zexp) were lower than theoretical additive dose values (Zadd; p < .05). Our results identify the super-additive (synergist) interaction between 3α-hydroxymasticadienonic acid and DLG and the gastric safety of both compounds in the indomethacin-induced gastric injury model, suggesting their potential in the future as a strategy to decrease the gastric damage associated to the chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs). K E Y W O R D S3α-hydroxymasticadienonic acid, diligustilide, gastric injury, isobolographic analysis, NSAIDs

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“…It is noteworthy that other plant species with the popular name "tila" are also used in México for "nervios", but they have been identified as species from the genus Ternstroemia. In the case of Ternstroemia pringlei the methanol and aqueous extracts from the fruits elicited sedative, but not anxiolytic, activity (Balderas et al, 2008;Lozada-Lechuga et al, 2010).…”

Section: Tilia Americana Var Mexicana (Schltdl) Hardin Malvaceaementioning

confidence: 96%

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

Gutierrez

Reyes-Chilpa

Jaime

2014

Revista Brasileira de Farmacognosia

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Pharmacodynamic interaction of the sedative effects of Ternstroemia pringlei (Rose) Standl. with six central nervous system depressant drugs in mice

Cited by 13 publications

References 27 publications

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

Pharmacodynamic interaction of 3α‐hydroxymasticadienonic acid and diligustilide against indomethacin‐induced gastric damage in rats

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

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