Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Chakraborty, Manodeep; Kamath, Jagadish V

doi:10.7897/2230-8407.050463

Cited by 9 publications

(21 citation statements)

References 12 publications

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“…were observed in 100% of the rats in CT-ISO (Cardiotoxic group with isoproterenol). Similar type of observation was also made by some other researchers 15,17 . However, 55.56% of rats in CT-ISO-PRO (Cardiotoxic group with isoproterenol after propranolol treatment), 75% of rats in CT-ISO-P (Cardiotoxic group with isoproterenol after peanut treatment) and 88.89% of rats in CT-ISO-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol) showed almost normal histological architecture of heart (photomicrograph 1).…”

Section: Resultssupporting

confidence: 88%

“…In the present study, the percent changes of body weight were almost similar to the findings reported by the various investigators from different countries 15 Again, in this study marked histological changes such as widespread myocardial disorganization improvement in histological architecture of isoproterenol induced cardiotoxic rats 18 .…”

Section: Discussionsupporting

confidence: 91%

“…Whereas, mild histological changes such as mild multifocal degeneration (photomicrograph 2), scanty lymphocyte infiltration (photomicrograph 3) was observed in rest of the rats. Different researchers of other countries observed almost similar type of findings by using different nuts and herbal plant 7,15 . On the contrary, some researchers observed that low dose of Tylophora indica herbal plant leaves failed to show any …”

Section: Resultssupporting

confidence: 53%

“…Scoring: 15,17 The histological changes of heart tissue in experimental animals determined by scoring method depending on the severity where score 0 = no change, score 1 = mild change (small multifocal degeneration with slight degree of inflammation, scanty inflammatory cell infiltration, absence of hyalinization of muscle fiber, reduced interstitial space), score 2 = moderate change (extensive myofibrillar degeneration, mild necrosis with inflammation, mild hyalinization of muscle fiber, mild inflammatory cell infiltration), score 3 = marked change (widespread myocardial disorganization, hyalinization of muscle fiber, degeneration of myofibrils, infiltration of lymphocyte and macrophage, loss of integrity of myocardial cell membrane, necrosis with diffuse inflammation, increased interstitial space).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, some other researchers found that consumption of peanut 5 times per week (about 155g of nuts/week) reduced the risk of death from coronary heart diseases by 35% 14 . Recently in an experimental study some researchers observed significant improvement in the histological structure in rats treated with conventional cardioprotective drug propranolol (â-blocker) along with Semecarpus anacardium (a species of nut closely related to cashew) nut extract in isoproterenol treated cardiotoxic rats 15 .…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Naz

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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Background: Cardiotoxicity (CT) can be developed due to prolonged use of higher doses of some drugs, exposure to some chemicals, toxins or infectious agents and also by some disease conditions. Natural plant foods such as peanut (Arachis hypogaea L.) may have free radical scavenging activity, thereby can be used for the prevention and management of heart disease. Objective: To observe the protective effect of peanut (Arachis hypogaea L.) and its combined action with propranolol on histological changes in isoproterenol induced cardiotoxic rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka in 2012. For this purpose, 20 Wistar albino rats, age 85-100 days, weighing 120 to 150g (initial body weight) were included in the peanut treated group. They were sub-divided into CT-ISO-P (Cardiotoxic group with isoproterenol after peanut treatment) and CT-ISO-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut supplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT-ISO (Cardiotoxic group with isoproterenol) and CT-ISO-PRO (Cardiotoxic group with isoproterenol after propranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats were sacrificed on 22 nd day. The heart was removed and preserved in 10% formalin for histological processing. To find out the histopathological changes of heart tissue, histological slides were prepared and were observed under microscope in the Department of Pathology, SSMC. Histological findings were categorized by scoring as mild, moderate and severe histological changes. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Result: In this study, percent change from initial body weight to final body weight was significantly (p<0.01) lower both in CT-ISO-P and CT-ISO-C as compared to that of BC. Again, histological score was significantly (p<0.01) higher in CT-ISO in comparison to that of BC. Moreover, these scores were significantly lower in CT-ISO-PRO (p<0.01), CT-ISO-P (p<0.05) and CT-ISO-C (p<0.05) in comparison to that of CT-ISO. Similarly, this score was significantly (p<0.01) lower in CT-ISO-C when compared to that of CT-ISO-P. Conclusion: The present study revealed that peanut can preserve almost normal histological architecture of heart tissue in isoproterenol induced cardiotoxic rats. However, the combined therapy of peanut with propranolol showed synergistic effect on preventing histological changes in heart tissue.

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Section: Resultssupporting

confidence: 88%

Section: Discussionsupporting

confidence: 91%

Section: Resultssupporting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Naz

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

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Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity

Bhatt¹,

Sebastian²,

Joshi³

2017

Journal of Ayurveda and Integrative Medicine

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BackgroundMangiferin is a highly potent antioxidant present in mango leaves which is utilized for therapeutic purposes.ObjectiveThe present study was undertaken to evaluate the cardioprotective effect of mangiferin against cyclophosphamide induced cardiotoxicity.Materials and methodsRats were treated with 100 mg/kg of mangiferin in alone and interactive groups for 10 days. Apart from normal and mangiferin control groups, all the groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on Day 1 and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile and histopathological evaluation.ResultsMangiferin treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidant levels. Compared to cyclophosphamide control group, mangiferin treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score and mortality.ConclusionThe present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.

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2023

IJPSR

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Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD's is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globally. There is hence a need of research of new molecules with improved therapeutics. Herbal medications have been utilized to treat cardiovascular diseases for many years around the world. The advancement of herbal nanotechnology in the field of CVDs has been shown to have astounding benefits over herbal crude drug formulations or herbal extracts, including better solubility, bioavailability, toxicity protection, pharmacological activity augmentation, dose reduction, and stability. This paper discusses the traditional herbal drugs and the herbal formulations, specifically herbal nanoparticles (NPs), for the treatment of CVDs and their advantages. INTRODUCTION:CVDs are the biggest cause of death worldwide and are expected to continue to be so. Coronavirus disease 2019 (COVID-19), caused by a coronavirus strain known as SARS-CoV-2, has spread worldwide, affecting billions of people. COVID-19 and cardiovascular disease appear to be linked, according to research. Patients with COVID-19 with pre-existing cardiovascular illness had the worst results and were more likely to die, whereas COVID-19 can also cause myocardial damage, arrhythmia, acute coronary syndrome, and venous thromboembolism, which has become a severe concern 1 .

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Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Cited by 9 publications

References 12 publications

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity

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