Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect

Khan, Arif Ullah; Gilani, A.H.

doi:10.38212/2224-6614.2355

Cited by 22 publications

(14 citation statements)

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“…Garlic has been shown to have antihypertensive, antihyperlipidemic, antioxidant, and antiatherosclerotic effects [14][15][16]. Terminalia bellirica is shown to have antioxidant and antihypertensive effects [17]. Curcuma aeruginosa rhizoma and Amomi fructus (Amomum compactum) or cardamom have also been proven as antioxidants [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats

Sholikhah

Mustofa

Nugrahaningsih

et al. 2020

BioMed Research International

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The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect on a rat model of hypertension. However, toxicity data were not available for this polyherbal formulation. This study is aimed at evaluating the acute and subchronic oral toxicity of the polyherbal formulation in rats. The acute toxicity study was conducted on 6 female Wistar rats using the fixed-dose method for the treatment group and 5 female Wistar rats for the control. The single dose of 2,000 mg/kg of the polyherbal formulation was given orally. There were no significant toxic effects and no death observed until the end of the study, and it was showed that the lethal dose 50% (LD50) of the polyherbal formulation was estimated to be more than 2,000 mg/kg. The macroscopic and microscopic examination of vital organs showed no symptoms of toxicity. At the subchronic toxicity study, the polyherbal formulation with 3 dose variations of 252 mg/kg, 1,008 mg/kg, and 4,032 mg/kg was administered for 91 days orally. The lowest dose of 252 mg/kg is equivalent to the daily recommended dose for a human. There were no significant toxic effects observed at all doses on physical sign and symptoms, weight gain, food intake, hematological parameters, biochemical parameters, and macroscopic and microscopic examination of organs. These findings showed that the short- and long-term oral administration of the polyherbal formulation is safe to use within its dose recommendation.

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Section: Introductionmentioning

confidence: 99%

Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats

Sholikhah

Mustofa

Nugrahaningsih

et al. 2020

BioMed Research International

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“…Terminalia bellerica is known to act as an antioxidant, anti‐hypertensive, hepatoprotective and antipyretic agent. It has been evaluated for its anti‐hypertensive effect in hypertension models: in rats under anaesthesia, in isolated guinea‐pig atria model and in thoracic aorta of rabbit (Khan & Gilanii, ; Dwivedi, et al, ). “Triphala” a well‐known Ayurvedic polyherbal formulations is the mixture of three (tri) fruits (phala) consisting of Emblica officinalis , Terminalia bellirica and Terminalia chebula .…”

Section: Herbs Administered In Cvd and Their Reported Hdi With Cardiomentioning

confidence: 99%

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Shaikh

Thomas

Chitlange

2020

Phytotherapy Research

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About 70% of the world population is currently using medicinal herbs as complementary or alternative medicine, which is increasing at a tremendous pace in both developed and developing countries in the last two decades (World Health Organization Medicines Strategy 2002–2005). This increase in consumer demand of medicinal herbs continues despite the rarity of scientific data to establish their safety and efficacy profile. Its popularity is also attributed to several factors, including easy availability, cost effectiveness leading to better purchasing power and general perception that they are safe. Herbs are often administered concomitantly with therapeutic drugs for the treatment of major ailments, raising the potential for herb–drug interactions (HDIs). The major pathways postulated for HDIs involves the cytochrome P450 (CYP450)‐mediated inhibition or induction and transport and efflux proteins. In our review, we highlight frequently used herbal medicines for the treatment of cardiovascular disorders (CVD), their established HDIs studied using in vitro tools and in vivo pharmacokinetic and pharmacodynamic assays and case reports. Herbs have been divided into different sections on the basis of availability of HDI data in relevance to cardiovascular drugs: herbs reported to interact with cardiac drugs, herbs yet to be reported for interaction with drugs of any class and herbs reported to interact with drugs of other therapeutic category but not with cardiac drugs. The amount of active phytoconstituents present in the selected herbs and their extent of bioavailability are also mentioned. This review can serve as a quick reference database for physicians and health care professionals involved in CVD treatment, aimed at maximizing clinical outcomes with reduction in adverse and toxic effects.

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“…The clinical study also indicates that A. sativum can lower blood pressure when compared with placebo [2]. Meanwhile, B. fructus or Terminalia bellerica or known as jelawe in Indonesia is also proved to have antioxidant and antihypertensive effects [3,4]. C. aeruginosa rhizome or locally known as temu ireng has demonstrated activity as an antioxidant [5,6].…”

Section: Research Articlementioning

confidence: 99%

“…The study of A. sativum on rat with two kidneys, one clip model of hypertension, showed that garlic blood pressure lowering activity is mediated by its activity on modulating nitric oxide which then causes vasodilatation [14]. Research on jelawe (B. fructus) showed that jelawe has antihypertensive and antioxidant effects [3,4]. B. fructus showed its antihypertensive effect by antagonizing the calcium (Ca) channel which was examined using rabbit thoracic aorta in vitro [4].…”

Section: Nugrahaningsih Et Almentioning

confidence: 99%

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Blood Pressure Lowering Effect of Polyherbal Preparation Containing Allium Sativum, Belericae Fructus, Curcuma Aeruginosa, and Amomi Fructus on Rat Model of Hypertension

Nugrahaningsih

Mustofa

et al. 2019

Asian J Pharm Clin Res

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Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension. Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats were divided into five groups that were no treatment (negative control group [NEG]), hydrochlorothiazide treatment, polyherbal preparation 63 mg/kg treatment (DOSE 1), polyherbal preparation 126 mg/kg treatment (DOSE 2), and polyherbal preparation 252 mg/kg treatment (DOSE 3). The treatment was started after hypertension developed and given for 3 weeks. Results: The result showed that the mean of systolic blood pressure in DOSE 2 group was significantly lower compared with those on NEG group (145.86 mmHg vs. 174.71 mmHg, p<0.05). Conclusion: Our study provides evidence to support the use of the polyherbal preparation containing A. sativum, B. fructus, C. aeruginosa, and A. fructus for lowering blood pressure.

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Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect

Cited by 22 publications

References 0 publications

Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats

Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Blood Pressure Lowering Effect of Polyherbal Preparation Containing Allium Sativum, Belericae Fructus, Curcuma Aeruginosa, and Amomi Fructus on Rat Model of Hypertension

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