Pharmacodynamic differences between racemic ibuprofen and dexibuprofen in murine preclinical study
HUGO F MIRANDA,
VIVIANA NORIEGA,
VICENTE AGUILERA
et al.
Abstract:Non-steroidal anti-inflammatory drugs (NSAIDs) are among the best therapeutic options to treat pain, but their use is restricted by their adverse effects. In this study, the pharmacological profile of ibuprofen and dexibuprofen was evaluated using the murine acetic acid writhing test, and the participation of naltrexone, naltrindole, nor-binaltorphimine, L-NAME, risperidone, and tropisetron in the antinociceptive efficacy. Antinociception was assessed by dose–response curves to ibuprofen and dexibuprofen befor… Show more
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