Pharmacodynamic Analysis of Antimalarials Used in Plasmodium falciparum Imported Malaria in Northern Italy

Caramello, Pietro; Canta, Francesca; Cavecchia, Ilaria; Sergi, Giuseppina; Lipani, Filippo; Calleri, Guido; Gobbi, Federico; Perri, Giovanni Di

doi:10.2310/7060.2005.12305

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Artemisinin dapat menurunkan kepadatan parasit lebih cepat daripada kuinin dan meflokuin. Dengan artemisinin kepadatan parasit turun sebesar 50% setelah 7,9 jam pemberian artemisinin dan turun sebesar 90% setelah 12 jam dan rata-rata parasit tidak terdeteksi lagi setelah 48 jam pemberian artemisinin (10). Artemisinin oral akan dikonversi menjadi bentuk metabolit aktif berupa dihidroartemisinin (DHA) yang mempunyai aktifitas puncak 1 jam setelah pemberian.…”

Section: Diskusiunclassified

EFEK KOMBINASI ARTEMISININ DAN N-acetylcysteineTERHADAP KADAR Malondialdehyde(MDA) OTAK DAN PARU MENCIT GALUR Balb/c YANG DIINFEKSI Plasmodium berghei

Fitri

Iskandar

Permatasari

et al. 2013

JKB

View full text Add to dashboard Cite

Cerebral and lung damage during malaria infection is believed to be caused by free radicals activities that are produced during immunology process. The free radicals react with lipid component of cellular membrane which generates malondialdehyde (MDA) as its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was more effective in decreasing cerebral and lung MDA level compared to artemisinin mono-therapy. The research was post-test-control-only design using 5 groups consisted of group A (negative control group), group B mice which infected with P.berghei without therapy (positive control group), group C mice which infected with P.berghei and received artemisinin mono-therapy (0.04 mg/g BW for 7 days), group D mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 7 days) and group E mice which infected with P.berghei and received artemisinin in combination with NAC (1 mg/g BW for 3 days and tapered into ½ mg/g BW for 4 days). On the 3 rd , 5 th ,and 7 th day, 3 mice from each group were scarified and assayed for MDA level. On the 3 rd day, a decreasing trend of cerebral and lung MDA level was observed on all treatment groups. On the 5 th day, a decreasing trend of cerebral and lung MDA level was observed in group that received artemisinin and NAC whereas group's that received artemisinin mono-therapy increased. Cerebral and lung MDA level of group that received artemisinin mono-therapy was significantly different with group that received combination of artemisinin and NAC in constant dose (p = 0.014) and with group that received combination artemisinin and NAC in tapering dose (p = 0.004). On the 7 th day, cerebral MDA level of group that received combination artemisinin and NAC in constant dose was significantly lower than the group that received artemisinin monotherapy (p = 0.005). In the lung, the MDA level of group that received artemisin mono-therapy increased, while the MDA level of combination group decreased. There was a significantly difference between group that receiving artemisinin mono-therapy and group that received combination of artemisinin and NAC tapering dose (p = 0.000). The conclusion is the combination of artemisinin and NAC is more effective in lowering cerebral and lung MDA level compared to artemisinin mono therapy on mice infected with P.berghei.

show abstract

Section: Diskusiunclassified