Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine

Hou, Min; Tang, Qing; Xue, Qiang; Zhang, Xiaona; Liu, Yang; Yang, Sihua; Chen, Liechun; Xu, Xiaoyu

doi:10.1016/j.jep.2016.11.025

Cited by 29 publications

(26 citation statements)

References 24 publications

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“…Further clinical studies are needed to validate this synergistic effect. Besides, a previous study found that the volatile oil of Radix Angelicae dahuricae could ameliorate nitroglycerin-induced migraine in rats [ 6 ]. Not surprisingly, the pharmacokinetic and pharmacodynamic synergistic effects might both exist when co-administration of Radix Angelicae dahuricae and ligustrazine.…”

Section: Discussionmentioning

confidence: 99%

“…Shan et Yuan. It is always co-administered with another medicine [ 6 , 7 ], such as ligustrazine ( Figure 1 ), a synthetic drug with different forms (e.g., tablet and injection) and is used for the clinical treatment of ischemic cerebrovascular disease and migraine in China [ 8 , 9 , 10 ]. Animal experimental evidence indicates that the main ingredients in Radix Angelicae dahuricae , furanocoumarins (such as imperatorin and isoimperatorin, Figure 1 ), have the potential to increase the pharmacokinetic and therapeutic effects of co-administered drugs [ 7 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

Feng

Zhong

et al. 2018

Molecules

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Radix Angelicae dahuricae, containing coumarins, which might affect cytochrome P450 enzyme (CYP450) activity, has been co-administered with ligustrazine, a substrate of CYP450s, for the clinical treatment of migraine. However, whether a pharmacokinetic-based synergy exists between Radix Angelicae dahuricae and ligustrazine is still unknown. In this study, the total coumarin extract (TCE) of Radix Angelicae dahuricae (50 mg/kg, orally) reinforced the anti-migraine activity of ligustrazine by declining head scratching, plasma calcitonin gene-related peptide, and serum nitric oxide, as well as increasing plasma endothelin levels in rats (p < 0.05). Moreover, the pharmacokinetic study reflected that TCE potentiated the area under the concentration–time curve of ligustrazine and prolonged its mean retention time in rats (p < 0.05). Besides, the IC50 for TCE, imperatorin and isoimperatorin inhibiting ligustrazine metabolism were 5.0 ± 1.02, 1.35 ± 0.46, 4.81 ± 1.14 µg/mL in human liver microsomes, and 13.69 ± 1.11, 1.19 ± 1.09, 1.69 ± 1.17 µg/mL in rat liver microsomes, respectively. Moreover, imperatorin and isoimperatorin were CYP450s inhibitors with IC50 < 10 µM for CYP1A2, 2C9, 2D6, and 3A4. Therefore, this study concluded that Radix Angelicae dahuricae could increase ligustrazine plasma concentration and then reinforce its pharmacological effect by inhibiting its metabolism through interference with CYP450s. This could be one mechanism for the synergy between Radix Angelicae dahuricae and ligustrazine on migraine treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

Feng

Zhong

et al. 2018

Molecules

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“…The method used in the present study was according to a previously published protocol (21). A total of 60 rats were randomly divided into five groups: Control, model, rizatriptan, VME high-dose (7 g/kg) and low-dose (1.75 g/kg) groups (n=12).…”

Section: Methodsmentioning

confidence: 99%

“…Traditional Chinese Medicine has the scope and long-reaching experience for the treatment of migraine (16,17), with acupuncture being a good example. Scutellaria baicalensis , Du Liang soft capsule, and other Chinese patent medicines have also proved effective for migraine (18–21). Fructus Viticis is the dried fruit of Vitex trifolia L. var.…”

Section: Introductionmentioning

confidence: 99%

Fructus�Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission

Wen

Chen

et al. 2019

Exp Ther Med

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Migraine, characterized by hyperalgesia of the trigeminovascular system, is a severe condition that leads to severe reductions in the quality of life. Upon external stimulation, the levels of various neurotransmitters, including aspartic acid (Asp), glutamic acid (Glu), γ-amino butyric acid (GABA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), are significantly altered; this directly or indirectly promotes trigeminal hypersensitivity. Fructus Viticis is a Traditional Chinese Medicine with analgesic properties to provide efficient relief of migraine. In the present study, the underlying mechanisms of the analgesic effect of Fructus Viticis methanolic extract were assessed in rats with nitroglycerin-induced migraine. The plasma levels of the neurotransmitters calcitonin gene-related peptide (CGRP) and substance P (SP), as well as the amount of c-fos immunoreactive cells (c-fos IR cells) in the brain, were detected. The analgesic effect was obvious, as Fructus Viticis methanolic extract ameliorated migraine-like behaviours in nitroglycerin-induced rats. The levels of 5-HT, GABA and NE in the brain of migraine model rats was lower compared with that of control rats, whereas opposite observations were made in the contents of excitatory amino acids. Pre-treatment with Fructus Viticis methanolic extract elevated the levels of 5-HT, GABA and NE, and also lowered the levels of excitatory amino acids, including Glu and Asp. In addition, treatment with Fructus Viticis methanolic extract lowered the plasma levels of CGRP and SP and decreased the c-fos IR cells in the brainstem. The present study provided a further scientific basis for the anti-migraine effects of Fructus Viticis.

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“…The Baizhi–Chuanxiong (BZ–CX) herb couple, consisting of Radix Angelicae Dahuricae (BaiZhi, BZ) and Rhizoma Chuanxiong (ChuanXiong, CX), which was first recorded in Pu Ji Fang , has been used for several centuries to treat migraine in China (Hou et al, ; Ran, Ma, Peng, Zhang, & Qin, ). Migraines are difficult to cure because the pathophysiology mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of ligustilide, dl‐3‐n‐butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction

Wang

Yan

Jiang

et al. 2019

Biomedical Chromatography

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The herb couple has special clinical significance in reducing the toxicity and increasing the efficacy of drugs. The combination of Radix Angelicae Dahuricae (Baizhi, BZ) andRhizoma Chuanxiong (ChuanXiong, CX) is a traditional herb couple. The combination performs better than the CX extract alone in the treatment of migraine and has been used for thousands of years. However, the specific compatibility mechanisms are still unclear. Ligustilide, DL-3-n-butylphthalide and senkyunolide A are the major active ingredients in CX and BZ-CX decoction. However, a comprehensive study of the pharmacokinetics of CX has not been carried out. A gas chromatography-mass spectroscopy (GC-MS) method with high selectivity, sensitivity and accuracy was developed. An SH-Rxi-5Sil (30 m × 0.25 mm i.d., and 0.25 μm film thickness) column was employed in the GC separation. Selectivity, linearity, precision, accuracy, recovery, matrix effect and stability were used to validate the current GC-MS method. Using the validated method, this is the first time to study on the comparative pharmacokinetics of ligustilide, DL-3-n-butylphthalide and senkyunolide A from CX alone and BZ-CX decoction in rat plasma. The pharmacokinetic parameters (C max , T max , T 1/2 , AUC 0-t , AUC 0-∞ and CLz/ F ) of all of the detected ingredients showed significant differences between the two groups (P < 0.05). The results are helpful for further investigation of the compatibility mechanism of BZ-CX decoction.

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Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine

Cited by 29 publications

References 24 publications

A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats

Fructus�Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission

Simultaneous quantification of ligustilide, dl‐3‐n‐butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction

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