Pharmacobotanical analysis and regulatory qualification of Capsicum fruits and Capsicum extracts. A survey.

Kuźma, Monika; Past, T; Mózsik, Gyula; Perjési, Pál

doi:10.5772/58812

Cited by 4 publications

(2 citation statements)

References 78 publications

(61 reference statements)

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“…2007; Kuzma et al 2014;Proudlock et al 2004). Together, our results suggest that capsaicin has an anti-genotoxic effect and may inhibit the DNA damage induced by DMH, as previously demonstrated by other (De et al 1995;Melgar-Lalanne et al 2017;Proudlock et al 2004).…”

Section: Discussionsupporting

confidence: 83%

Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Caetano

Tablas

Pereira

et al. 2018

Toxicology and Applied Pharmacology

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Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is the major pungent ingredient found in chili peppers consumed worldwide. Most reports on capsaicin potential carcinogenicity have yielded inconsistent findings. Some studies have shown that capsaicin exerts anti-proliferative and pro-apoptotic effects on different cancer cell lines, while others have reported an association between capsaicin at high doses with mutagenicity and carcinogenicity. Thus, this study aimed at assessing the effects of capsaicin administration on 1,2-dimethyl-hydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. Our results show that capsaicin administration, before and during carcinogen exposure, modified DMH-induced cytotoxicity and genotoxicity, promoting anti-proliferative and pro-apoptotic responses through the expression of the genes involved in apoptosis, cell cycle suppression and cell/tissue differentiation. Furthermore, capsaicin reduced aberrant crypt foci (ACF) number and multiplicity, although there were no differences in tumor incidence and multiplicity among the groups. Taken together, the results suggest that capsaicin may have a preventive effect against DMH-induced colorectal carcinogenesis.

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Section: Discussionsupporting

confidence: 83%

Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Caetano

Tablas

Pereira

et al. 2018

Toxicology and Applied Pharmacology

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“…It was earlier demonstrated that capsaicinoids display analgesic action [5,6,7,8,9], protect the gastric mucosa against the damage caused by the non-steroid anti-inflammatory drugs (NSAIDs) and alcohol [10,11,12,13,14,15], have anti-inflammatory effect [16,17,18], as well as anti-tumor and antioxidant potential [19,20,21]. Much of the published literature on capsaicin relates to capsaicin containing pepper extracts; these extracts are typically a mixture of capsaicin, dihydrocapsaicin, and the minor capsaicinoids nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin [22]. The actual percentage of capsaicin and other capsaicinoids of the extracts varies depending on the peppers and the method of extraction.…”

Section: Introductionmentioning

confidence: 99%

Toxicokinetic Study of a Gastroprotective Dose of Capsaicin by HPLC-FLD Method

et al. 2019

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Background: A low dose of capsaicin and its natural homologs and analogs (capsaicinoids) have shown to prevent development of gastric mucosal damage of alcohol and non-steroid anti-inflammatory drugs. Based on this experimental observation, a drug development program has been initiated to develop per os applicable capsaicin containing drugs to eliminate gastrointestinal damage caused by non-steroid anti-inflammatory drugs. Methods: As a part of this program, a sensitive and selective reverse-phase high-performance liquid chromatography-based method with fluorescence detection has been developed for quantification of capsaicin and dihydrocapsaicin in experimental dog’s plasma. Results: The method was evaluated for a number of validation characteristics (selectivity, repeatability, and intermediate precision, LOD, LOQ, and calibration range). The limit of detection (LOD) was 2 ng/mL and the limit of quantification (LOQ) was 10 ng/mL for both capsaicin and dihydrocapsaicin. The method was used for analysis of capsaicin and dihydrocapsaicin in the plasma samples obtained after per os administration of low doses (0.1, 0.3, and 0.9 mg/kg bw) of Capsaicin Natural (USP 29) to the experimental animals. Conclusions: The obtained results indicated that the administered capsaicinoids did not reach the general circulation.

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Current Information on <i>Capsicum frutescens</i>: A Critical Review of Pharmacological Potential

Chinnkar

Jadhav

2023

IJND

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Capsicum frutescens is a species of the Solanaceae family of the genus Capsicum, which has around 20 species, five of which are regularly cultivated: “Capsicum annuum, Capsicum baccatum, Capsicum chinense, Capsicum frutescens, and Capsicum pubescens.” Since ancient times, C. frutescens has been used to taste and colour food all throughout the world. However, it is also employed for its medical benefits by many civilizations all over the world. This prompted researchers to concentrate on its chemical components, which led to a number of studies. The components isolated from C. frutescens such as capsaicinoids, carotenoids, and saponins authenticated its antibacterial, antidiabetic, anti-fungal, cardiovascular, thrombolytic, anti-cancer, and anti-oxidant activities along with a few more through various studies. This review focuses on all the pharmacological properties of these components highlighting the significance of Capsicum frutescens in herbal medicine.

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Pharmacobotanical analysis and regulatory qualification of Capsicum fruits and Capsicum extracts. A survey.

Cited by 4 publications

References 78 publications

Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Toxicokinetic Study of a Gastroprotective Dose of Capsaicin by HPLC-FLD Method

Current Information on <i>Capsicum frutescens</i>: A Critical Review of Pharmacological Potential

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