2019
DOI: 10.1002/jac5.1166
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Pharmacists' perceptions and practice changes resulting from emergence of the vancomycin‐piperacillin/tazobactam nephrotoxicity phenomenon

Abstract: Purpose To elucidate the considerations pharmacists have when using concomitant vancomycin and piperacillin/tazobactam (VPT) and strategies implemented across hospitals in response to published data on this phenomenon. Methods A survey of pharmacist members of the infectious diseases and critical care (CC) practice and research networks of the American College of Clinical Pharmacy was conducted. Participants were grouped based on their belief (yes or no) in the association between VPT and acute kidney injury (… Show more

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Cited by 3 publications
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“…Importantly, the number of studies published on the potential nephrotoxicity of vancomycin and piperacillin-tazobactam have influenced prescribing patterns, which may have downstream implications. In a survey of infectious disease and critical care pharmacists, 89% of respondents reported a belief that the combination of vancomycin and piperacillin-tazobactam resulted in an increased probability of developing AKI compared with vancomycin alone or in combination with other beta-lactam antibiotics (5). Of those respondents, 64% reported they less frequently recommend the combination of vancomycin and piperacillin-tazobactam in a patient with existing AKI (5).…”
Section: Discussionmentioning
confidence: 99%
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“…Importantly, the number of studies published on the potential nephrotoxicity of vancomycin and piperacillin-tazobactam have influenced prescribing patterns, which may have downstream implications. In a survey of infectious disease and critical care pharmacists, 89% of respondents reported a belief that the combination of vancomycin and piperacillin-tazobactam resulted in an increased probability of developing AKI compared with vancomycin alone or in combination with other beta-lactam antibiotics (5). Of those respondents, 64% reported they less frequently recommend the combination of vancomycin and piperacillin-tazobactam in a patient with existing AKI (5).…”
Section: Discussionmentioning
confidence: 99%
“…In a survey of infectious disease and critical care pharmacists, 89% of respondents reported a belief that the combination of vancomycin and piperacillin-tazobactam resulted in an increased probability of developing AKI compared with vancomycin alone or in combination with other beta-lactam antibiotics (5). Of those respondents, 64% reported they less frequently recommend the combination of vancomycin and piperacillin-tazobactam in a patient with existing AKI (5). This would appear to complicate the antibiotic selection for patients with sepsis and AKI.…”
Section: Discussionmentioning
confidence: 99%
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