C ARDIOVASCULAR DISEASE (CVD) is the leading cause of death in North America. 1 Dyslipidemia is one of a number of risk factors such as age, sex, hypertension, diabetes, and smoking that independently increases the risk for coronary disease. 2,3 More than half (50.7%) of adults older than 20 years have total cholesterol concentrations greater than 200 mg/dL. 1 Furthermore, just less than one half (45.8%) of the population has a low-density lipoprotein cholesterol (LDL-C) concentration greater than 130 mg/dL. 1 Given that LDL-C is the most atherogenic component of the lipid profile and the primary target for most therapeutic interventions, a significant number of patients require lipid-modifying therapy to decrease LDL-C to target values.There have been numerous large-scale, randomized clinical trials demonstrating the benefit of aggressive lipid-modifying therapy, particularly with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ("statins"), in reducing the mortality and morbidity associated with CVD. 4-11 Patients with documented CVD derive the greatest benefit from aggressive lipid-modifying therapy. [4][5][6][7]11 Despite the abundance of literature supporting aggressive use of lipid-modifying therapy and the wide dissemination of clinical practice guidelines outlining management strategies for patients, particularly those at the greatest cardiovascular risk, studies indicate that a significant proportion of patients are not screened, initiated on appropriate therapy, or treated to target lipid levels. 12,13 Less than one half of the population, including those with documented CVD, who are eligible for lipid-modifying therapy receive it. 12,13 Furthermore, long-term patient adherence to these therapies after they are prescribed is poor. Approximately 50% of the population prescribed lipid-modifying therapy is still on it at 1 year. 14,15 In an effort to close the so-called treatment gap and address patient, physician, and health care system factors likely responsible for this gap, multidisciplinary teams that focus on cardiac risk factor management are essential to assist patients in achieving lipid targets. Pharmacists, as part of the multidisciplinary team, can play a vital role in assisting Dyslipidemia is one of a number of independent risk factors for cardiovascular disease. Numerous large-scale, randomized clinical trials demonstrate the benefit of aggressive lipid-modifying therapy in reducing the mortality and morbidity associated with cardiovascular disease. Despite these data and the wide dissemination of clinical practice guidelines outlining management strategies for patients with dyslipidemia, particularly those at the greatest cardiovascular risk, studies indicate that a significant proportion of patients are not screened, initiated on appropriate therapy, or treated to target lipid levels. Pharmacists, as part of the multidisciplinary team, can play a vital role in assisting in the management of patients with dyslipidemias. This article reviews published studies that have evaluate...