Pharmacia and biological functionalities of nutrient broth dispersed multi-walled carbon nanotubes: A novel drug delivery system

Abstract

A new drug delivery system was developed using the interaction of nutrient broth treated multi-walled carbon nanotubes (NBT-MWCNTs) and cefotaxime sodium (CTX) as a model. Investigated factors of the drug delivery system include dispersion effect, biocompatibility of NBT-MWCNTs, pharmacodynamic effect and delivery efficiency in vitro. It was found that MWCNTs can be well dispersed in the nutrient broth and stable at least for one week at 4 °C. The formed NBT-MWCNTs suspension scarcely exhibits toxicity to E. coli at concentrations lower than 10.24 g/mL, but displays enhanced pharmacodynamic effect of CTX via its bridge effect and targeted transport. Compared with general acid treated MWCNTs (AT-MWCNTs), our present NBT-MWCNTs show good biocompatibility, enhanced pharmacodynamic effect, and high delivery efficiency.drug delivery system, multiwalled carbon nanotubes, biocompatibility, pharmacodynamic effect, flow cytometry

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

“…Among diverse classes of HNDDSs, those based on the carbon nanotubes have attracted particular attention as carriers for biologically relevant molecules due to their unique properties such as the ability to cross cell membranes and high surface area per unit weight for high drug loading. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] A varity of HNDDSs based on the carbon nanotubes have been recently prepared and tested in vitro and in vivo for delivery of drugs. [25][26][27][28][29][30][31] Poor water solubility and low functionality are two critical factors that influence the performance of CNTs for biomedical applications.…”

Carbamazepine drug using multi walled carbon nanotubes

“…In another study, MWCNTs were introduced for genetically modified Bifidobacterium longum because they can be transformed into a thick membrane 15 . MWCNTs are considered as a novel drug delivery system for the interaction of nutrient broth-treated (NBT) and cefotaxime sodium (CTX) 16 . In general, the interaction between drug and MWCNT carrier can be in different ways [17][18][19][20] .…”