Pharmaceuticals' sorptions relative to properties of thirteen different soils

Kodešová, Radka; Grabic, Roman; Kočárek, Martin; Klement, Aleš; Golovko, Oksana; Fér, Miroslav; Nikodem, Antonín; Jakšík, Ondřej

doi:10.1016/j.scitotenv.2014.12.088

Cited by 155 publications

(127 citation statements)

References 60 publications

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“…This approach has been used for other ionisable compounds in different environmental matrices [40,59]. Multiple linear regression analysis was performed to explore relationships between sediment and chemical properties and sorption coefficients (Kd) for each individual pharmaceuticals.…”

Section: Multiple Linear Regressions For Kd Predictionmentioning

confidence: 99%

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Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems

Al-Khazrajy

Boxall

2016

Journal of Hazardous Materials

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Sorption is a key factor in determining the persistence, attenuation and bioavailability of sediment-associated contaminants. However, our understanding of the sorption behaviour of pharmaceuticals in sediments is poor. In this study, we investigated the sorption behaviour of a diverse set of pharmaceuticals in a range sediment types. Sorption affinity of pharmaceuticals for all sediments was found to increase in the order mefenamic acid < cimetidine < atenolol < amitriptyline < diltiazem. Comparison of the experimental observations with predictions from an existing model for estimating sorption revealed the model worked poorly for the study pharmaceuticals. Multiple linear regression analysis was therefore used to develop new models for estimating sorption of individual pharmaceuticals based on sediment properties. The analyses indicated that sorption is related to properties such as Log Dow of a compound in the the sediment (lipophilicity corrected for the sediment pH), cation exchange capacity, clay%, organic carbon content and exchangeable Ca 2+ , although, with the exception of atenolol, robust relationships between sediment properties and sorption were not obtained. Overall, the results demonstrate how complex the processes are that drive the sorption of pharmaceuticals in sediments and highlight the need for generation of further experimental data and further model development work.

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Section: Multiple Linear Regressions For Kd Predictionmentioning

confidence: 99%

“…In addition, basic ionisable compounds are known to interact to clay fraction via electrostatic interaction to surface particles [40,58]. However, the high surface area of clay leads to an increase in the number of available sorption sites [59].…”

Section: +mentioning

confidence: 99%

Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems

Al-Khazrajy

Boxall

2016

Journal of Hazardous Materials

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“…The number of studies dealing with the sorption of different compounds in various matrices related to soil and subsurface water environment has recently increased (e.g. Kodešová et al 2015;Schaffer & Licha 2015;Klement et al 2018). The sorption of non-ionic (neutral) molecules is mainly driven by hydrophobic partitioning to the soil organic matter via van der Waals and electron donor-acceptor interactions and by hydrogen bonding with hydroxyl groups on the solid surfaces and therefore is highly dependent on the soil organic matter content.…”

mentioning

confidence: 99%

“…The sorption of non-ionic (neutral) molecules is mainly driven by hydrophobic partitioning to the soil organic matter via van der Waals and electron donor-acceptor interactions and by hydrogen bonding with hydroxyl groups on the solid surfaces and therefore is highly dependent on the soil organic matter content. The sorption of cationic molecules is mainly governed by the attraction to negative charges of the solid surface (e.g., a clay mineral surface or organic matter) and thus is controlled by the cation exchange capacity or by the basic cation saturation (Kodešová et al 2015). The anionic molecules are eventually sorbed on the positively charged surface of soil constituents (edges of layered clay, radical fragment of humus) via cation bridging on negative charges.…”

mentioning

confidence: 99%

Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess

Fér¹,

Kodešová²,

Golovko³

et al. 2018

Soil Water Res.

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Fér M., Kodešová R., Golovko O., Schmidtová Z., Klement A., Nikodem A., Kočárek M., Grabic R. (2018): Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess. Soil & Water Res., 13: 177−183.The leakage of pharmaceuticals present in soils towards groundwater is largely controlled by sorption of those compounds in soils. In some soils, soil aggregates are covered by coatings, which may have considerably different composition in comparison to that in an inner part of the aggregates. The aim of this study was to evaluate the sorption of three pharmaceuticals, which were applied in single or all compounds solutions, onto soil samples taken from the Bt horizon of a Haplic Luvisol. Analyses were performed on three types of disturbed soil samples: (1) entire aggregates, (2) aggregates from which coatings were removed, and (3) clay-organic coatings. Sorption of atenolol onto material from coatings was slightly higher than that onto material from the inner parts of the aggregates. On the other hand, sorption of sulfamethoxazole onto material from the coatings was lower than that from the aggregate interior. Both associates with a dominant fraction of clay particles (that are mostly negatively charged) in the coatings in comparison to soil composition in interiors and thus larger cation exchange capacity, which increased sorption of the positively charged atenolol and decreased sorption of the negatively charged sulfamethoxazole. Sorption of carbamazepine, which was in neutral form, did not substantially differ. The sorption of all three compounds did not decrease due to the competition between these compounds for the same sorption sites when applied simultaneously. Atenolol sorption was similar for both applications. Sorption of sulfamethoxazole increased when applied in solution with the other two compounds in comparison to its negligible sorption measured for the single compound solution likely due to sorption of the positively charged molecules of atenolol onto the negatively charged surface of soil components and reduction of repulsion between the soil components and the negatively charged molecules of sulfamethoxazole. Carbamazepine sorption also increased probably due to ionization of molecules due to dipole -induced dipole interaction between non-polar and polar molecules in solution.

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“…They observed dramatic reduction in ibuprofen sorption by all three minerals with increasing pH. Inverse relationships between the sorption and the soil pH are also common for other acidic pharmaceuticals like naproxen (Schaffer et al 2012) and sulfamethoxazole (Kodešová et al 2015). An additional explanation of the decreased sorption of ibuprofen in soil at higher pH is that ibuprofen anions are more soluble and hydrophilic than their neutral counterparts (octanol-water partition coefficient logK ow = 4.91 for the neutral ibuprofen vs 1.39 for the ibuprofen anion; Kerns et al (2003)), supressing its sorption interactions with natural solids.…”

Section: Resultsmentioning

confidence: 88%

Effect of temperature and soil pH on the sorption of ibuprofen in agricultural soil

Hiller¹,

Šebesta²

2017

Soil Water Res.

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Hiller E., Šebesta M. (2017): Effect of temperature and soil pH on the sorption of ibuprofen in agricultural soil. Soil & Water Res., 12: 78−85.Besides many natural factors, soil pH and temperature can have significant effects on the sorption of pharmaceuticals in soils. This is the first study, which aimed to evaluate the effect of soil pH and temperature on the sorption of ibuprofen in soil. Sorption-desorption experiments at 20°C indicated weak retention of ibuprofen in the soil. Sorption of ibuprofen in the soil was affected by both temperature and pH with the latter showing much greater effect. The extent of ibuprofen sorption increased with decreasing pH mainly due to the change of ibuprofen speciation from negatively charged ions at high pH to the neutral form at low pH. At pH 4, the distribution coefficient K d was 1.30 l/kg, whereas at pH 8, it was only 0.42 l/kg. When temperature increased, the sorption of ibuprofen decreased, showing that its sorption was exothermic.

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Pharmaceuticals' sorptions relative to properties of thirteen different soils

Cited by 155 publications

References 60 publications

Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems

Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems

Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess

Effect of temperature and soil pH on the sorption of ibuprofen in agricultural soil

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