Pharmaceuticals: Natural Products and Natural Product Models

Singh, Sheo B.

doi:10.1002/9780470048672.wecb444

Wiley Encyclopedia of Chemical Biology 2008

DOI: 10.1002/9780470048672.wecb444

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Pharmaceuticals: Natural Products and Natural Product Models

Sheo B. Singh

Abstract: Natural products have played a vital role in the treatment of human ailments for thousands of years and continue to play a big role in the modern discovery of new agents for the treatment of diseases today. In certain therapeutic areas, natural products account for almost all key modern medicine used today. Many drugs are formulated and used directly as they are found in nature, some are derived directly from natural products by semisynthesis, and others are modeled after natural products. In this overview, ex… Show more

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2013

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Cited by 1 publication

References 145 publications

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Current Developments of Coumarin Compounds in Medicinal Chemistry

Peng¹,

Damu²,

Zhou

2013

CPD

411

170

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Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such as anticoagulant and antineurodegenerative agents have been extensively used in clinic. Coumarin-containing supramolecular medicinal agents as a new increasing expansion of supramolecular chemistry in pharmaceutical science have also been actively investigated in recent years. Coumarin-derived artificial ion receptors, fluorescent probes and biological stains are growing quickly and have a variety of potential applications in monitoring timely enzyme activity, complex biological events as well as accurate pharmacological and pharmacokinetic properties. This review provides a systematic summary and insight of the whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains. Some rational design strategies, structure-activity relationships and action mechanisms are discussed. The perspectives of the future development of coumarinbased medicinal chemistry are also presented.

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Current Developments of Coumarin Compounds in Medicinal Chemistry

Peng¹,

Damu²,

Zhou

2013

CPD

411

170

View full text Add to dashboard Cite

show abstract

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Pharmaceuticals: Natural Products and Natural Product Models

Cited by 1 publication

References 145 publications

Current Developments of Coumarin Compounds in Medicinal Chemistry

Current Developments of Coumarin Compounds in Medicinal Chemistry

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