Pharmaceuticals in water and sediment of small streams under the pressure of urbanization: Concentrations, interactions, and risks

Kondor, A.; Molnár, Éva D.; Jakab, Gergely; Vancsik, Anna; Filep, Tibor; Szeberényi, József; Szabó, László Z.; Maász, Gábor; Pirger, Zsolt; Weiperth, András; Ferincz, Árpád; Staszny, Ádám; Dobosy, Péter; Kiss, Katalin Horváthné; Hatvani, István Gábor; Szalai, Zoltán

doi:10.1016/j.scitotenv.2021.152160

Cited by 23 publications

(11 citation statements)

References 92 publications

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“…In this study, the concentrations of psychotropic pharmaceuticals and their metabolites detected were generally lower than most values reported in the literature for surface water. For instance, the CBZ concentrations observed in this study (1.5 to 2.8 ng/L) were lower than those reported for western French river waters (39 to 65 ng/L) and Hungarian surface waters (ND to 58.9 μg/L) . RIS (ND to 3.3 ng/L) and 9-OH-RIS (ND to 0.3 ng/L), commonly prescribed antipsychotic medications, have limited information on their occurrence in surface water.…”

Section: Resultscontrasting

confidence: 88%

“…For instance, the CBZ concentrations observed in this study (1.5 to 2.8 ng/ L) were lower than those reported for western French river waters (39 to 65 ng/L) 14 and Hungarian surface waters (ND to 58.9 μg/L). 36 RIS (ND to 3.3 ng/L) and 9-OH-RIS (ND to 0.3 ng/L), commonly prescribed antipsychotic medications, have limited information on their occurrence in surface water. These compounds were detected at slightly lower concentrations compared to those reported for the Aegean Sea from Greece [e.g., RIS (ND to 3.2 ng/L) and 9-OH-RIS (ND to 11.8 ng/L)].…”

Section: Psychotropic Pharmaceuticals and Their Metabolites In Surfacementioning

confidence: 99%

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Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

et al. 2023

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Psychotropic pharmaceuticalsand their metabolites are a growing concern for aquatic environments and may accumulate in aquatic organisms. In this study, 21 parent psychotropic pharmaceuticals and 8 metabolites from three categories of psychotropic drugs (anxiolytics, antiepileptics, and antidepressants) were evaluated in Gao–Bao–Shaobo lake (GBSL), a shallow lake in China. Among them, 18 psychotropic pharmaceuticals and 8 metabolites were detected in water samples from GBSL (0.2 up to ∼24.5 ng/L), and 13 psychotropic pharmaceuticals and 5 metabolites were identified in fish (1 up to ∼126.2 ng/g dw). In the wet season, concentrations of psychotropic pharmaceuticals and their metabolites showed an increase from the inflow to the discharge subarea. Carbamazepine and sertraline were the dominant pharmaceuticals detected in fish with bioaccumulation factors, exceeding 5000 L/kg. Physicochemical parameters (log K ow and MW) were negatively correlated with the pharmaceutical levels in fish. Carbamazepine posed a moderate risk to aquatic organisms in all subareas. Hazard quotient results showed that the consumption of fish from GBSL is unlikely to exhibit a direct adverse effect on humans. Our results indicated that a comprehensive understanding of psychotropic pharmaceutical contaminations in surface waters should consider not only the parent pharmaceuticals but also the subsequent accumulation of their metabolites in fish.

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Section: Resultscontrasting

confidence: 88%

Section: Psychotropic Pharmaceuticals and Their Metabolites In Surfacementioning

confidence: 99%

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

et al. 2023

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“…When analyzing samples taken from rivers within Krakow (samples 1–8), it is noticed that in the Vistula and its tributaries, the studied pharmaceuticals are present at comparable levels of concentration. This confirms that pollutants dissolved in water, such as pharmaceuticals, have the ability to accumulate in the bottom sediments of tributaries, as confirmed by other researchers [ 36 , 37 , 38 ].…”

Section: Discussionsupporting

confidence: 88%

Determination and Removal of Selected Pharmaceuticals and Total Organic Carbon from Surface Water by Aluminum Chlorohydrate Coagulant

et al. 2022

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In the present research, the removal of Total Organic Carbon (TOC) and erythromycin (ERY), fluoxetine (FLX), amoxicillin (AMO), colistin (COL), ethynylestradiol (EE), and diclofenac (DIC) from surface water by coagulation is studied. The concentration of selected pharmaceuticals in 24 surface water samples originating from some rivers located in Lesser Poland Voivodeship and Silesia Voivodeship, Poland, was determined. The removal of TOC and pharmaceuticals was carried out using the application of Design of Experiments (DOE), Response Surface Methodology (RSM), and by addition of aluminum chlorohydrate (ACH) as a coagulant. The study found that the concentration ranges of ERY, FLX, AMO, COL, EE, and DIC in analyzed water samples were 7.58–412.32, 1.21–72.52, 1.22–68.55, 1.28–32.01, 5.36–45.56, 2.20–182.22 ng/L, respectively. In some cases, concentrations lower than 1 ng/L were determined. In optimal conditions of coagulation process of spiked surface water (pH = 6.5 ± 0.1, ACH dose = 0.35 mL/L, Time = 30 min; R2 = 0.8799, R2adj = 0.7998), the concentration of TOC, ERY, FLX, AMO, COL, EE, and DIC was decreased by 88.7, 36.4, 24.7, 29.0, 25.5, 35.4, 30.4%, respectively. Simultaneously, turbidity, color, Total Suspended Solids (TSS), Chemical Oxygen Demand (COD), Total Nitrogen (Total N), and Ammonium-Nitrogen (N-NH4) were decreased by 96.2%, >98.0%, 97.8%, 70.0%, 88.7%, 37.5%, respectively. These findings suggest that ACH may be an optional reagent to remove studied pharmaceuticals from contaminated water.

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“…Environmental risk assessment was performed by calculating risk quotients (RQs) for arti cial sweeteners detected in each river water and sediment sample. RQs were calculated by dividing the measured environmental concentration (MEC) of each sweetener with the corresponding predicted noeffect concentration (PNEC) for freshwater or sediment (Alves et al 2021;Kondor et al 2022). In principle, the PNEC is calculated by dividing the lowest short-term EC50 (median effective concentration), shortterm LC50 (median lethal concentration) or long-term NOEC (no observed effect concentration) by the appropriate assessment factor (AF).…”

Section: Environmental Risk Assessmentmentioning

confidence: 99%

Untreated Wastewater Impact and Environmental Risk Assessment of Artificial Sweeteners in River Water and Sediments of the Danube River Basin in Serbia

Gvozdić¹,

Bujagić

Đurkić

et al. 2023

Preprint

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Artificial sweeteners are receiving increasing attention as newly recognized emerging contaminants that mainly reach the aquatic environment through the discharge of municipal wastewater containing large amount of these compounds. In this study, the impact of raw untreated wastewater discharges on the levels and the water/sediment distribution of artificial sweeteners in the Danube River and its largest tributaries in Serbia was evaluated, and a comprehensive assessment of environmental risks for freshwater and benthic organisms was performed. Acesulfame and sucralose were detected in all river water samples, while saccharin and cyclamate were less frequently found, indicating long-term continuous sewage-derived pollution. Aspartame and neotame were the only artificial sweeteners recorded in the sediment samples due to their preference to sorb to particulate matter in the water/sediment system. In terms of ecotoxicological risk, a low risk for aquatic organisms was determined at the detected levels of saccharin in river water, while a high to medium risk was found for benthic biota at the concentrations of neotame and aspartame detected in sediments. The largest contribution to the pollution of the Danube River Basin with artificial sweeteners, and consequently the highest environmental risk, was determined in the two largest cities, the capital Belgrade and Novi Sad, which raises the issue of transboundary pollution.

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Pharmaceuticals in water and sediment of small streams under the pressure of urbanization: Concentrations, interactions, and risks

Cited by 23 publications

References 92 publications

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

Occurrence and Bioaccumulation of Psychotropic Pharmaceuticals and Their Metabolites in Water and Fish in a Shallow Lake in China: Implications for Ecological and Human Health Risks

Determination and Removal of Selected Pharmaceuticals and Total Organic Carbon from Surface Water by Aluminum Chlorohydrate Coagulant

Untreated Wastewater Impact and Environmental Risk Assessment of Artificial Sweeteners in River Water and Sediments of the Danube River Basin in Serbia

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