Pharmaceuticals and trace metals in the surface water used for crop irrigation: Risk to health or natural attenuation?

Santiago-Martín, Ana de; Meffe, Raffaella; Teijón, Gloria; Martínez-Hernández, Virtudes; López-Heras, Isabel; Alonso-Alonso, Covadonga; Romasanta, Marta Arenas; Bustamante, Irene de

doi:10.1016/j.scitotenv.2019.135825

Cited by 56 publications

(28 citation statements)

References 37 publications

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“…These data strongly suggest an environmental exposure besides the self-medication-related exposure. In agreement, IBU, DCF, and APAP have been detected in 2.5–23% of raw water and in 1–4% of treated water (low ng/L) samples ( ANSES Laboratory, 2011 ) ( Wee and Aris, 2017 ) and also in effluents from treatment plants and surface waters (few hundred ng/L) ( Aydin et al, 2019 ; De Santiago-Martin et al, 2020 ; Palma et al, 2020 ), indicating that they are not completely removed at wastewater treatment plants. IBU and DCF are also often found in drinking water ( Rabiet et al, 2006 ; Mompelat et al, 2009 ; Wang et al, 2017 ; Nantaba et al, 2020 ; Palma et al, 2020 ).…”

Section: Nonsteroidal Anti-inflammatory Drugs and Analgesics: Use And...mentioning

confidence: 68%

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

et al. 2022

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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid), diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or paracetamol), are widely used to treat inflammation and pain. APAP and IBU are over-the-counter drugs and are among the most commonly taken drugs in the first trimester of pregnancy, even in combination. Furthermore, these drugs and their metabolites are released in the environment, and can be frequently detected in wastewater, surface water, and importantly in drinking water. Although their environmental concentrations are much lower than the therapeutics doses, this suggests an uncontrolled low-dose exposure of the general population, including pregnant women and young children, two particularly at risk populations. Epidemiological studies show that exposure to these molecules in the first and second trimester of gestation can favor genital malformations in new-born boys. To investigate the cellular, molecular and mechanistic effects of exposure to these molecules, ex vivo studies with human or rodent gonadal explants and in vivo experiments in rodents have been performed in the past years. This review recapitulates recent data obtained in rodent models after in utero or postnatal exposure to these drugs. The first part of this review discusses the mechanisms by which NSAIDs and analgesics may impair gonadal development and maturation, puberty development, sex hormone production, maturation and function of adult organs, and ultimately fertility in the exposed animals and their offspring. Like other endocrine disruptors, NSAIDs and APAP interfere with endocrine gland function and may have inter/transgenerational adverse effects. Particularly, they may target germ cells, resulting in reduced quality of male and female gametes, and decreased fertility of exposed individuals and their descendants. Then, this review discusses the effects of exposure to a single drug (APAP, aspirin, or IBU) or to combinations of drugs during early embryogenesis, and the consequences on postnatal gonadal development and adult reproductive health. Altogether, these data may increase medical and public awareness about these reproductive health concerns, particularly in women of childbearing age, pregnant women, and parents of young children.

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Section: Nonsteroidal Anti-inflammatory Drugs and Analgesics: Use And...mentioning

confidence: 68%

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

et al. 2022

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“…The quantification of samples was carried out by the method developed by Santiago-Martín et al [26]. Briefly, samples were analyzed using a 1200 series liquid chromatograph coupled to a triple quadrupole, equipped with an electrospray ionisation interface (ESI).…”

Section: The Hplc-ms/ms Separation and Determination Proceduresmentioning

confidence: 99%

“…The injection volume was set at 20 µL. [26]. The quantification method showed appropriate instrumental analytical parameters.…”

Section: The Hplc-ms/ms Separation and Determination Proceduresmentioning

confidence: 99%

“…Recent studies have shown the effect of micropollutant properties on their ability to be absorbed by roots, and to translocated and bioconcentrated in the rest of the plant [24]. Indeed, very few studies mention the uptake of pharmaceuticals in field experiments [25,26] under similar conditions to those of agricultural practices, apart from hydroponic ones, where roots come into direct contact with pharmaceutical solutions [27]. Christou et al [28] point out the need to study the uptake of pollutants by plants during agricultural practices.…”

Section: Introductionmentioning

confidence: 99%

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Soil and Water Management Factors That Affect Plant Uptake of Pharmaceuticals: A Case Study

Mendoza-Grimón

Fernández-Vera²,

Hernández‐Moreno

et al. 2022

Water

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Water and food security are of global concern. Improving knowledge on crops’ potential uptake of pharmaceutical compounds (PhCs) is necessary to guarantee consumer health and improve the public’s perception of reclaimed water reuse. This study aimed to determine how water management (bottom-up applied for being supplied by Subsurface Drip Irrigation) and the plant rhizosphere effect on the uptake of PhCs. Five PhCs were mixed: atenolol, carbamazepine, dicoflenac, ibuprofen and valsartan. A total of 5 treatments were considered: 3 concentrations of PhCs in agricultural volcanic soil: 0.1, 10 and 100 µg·L−1; 0.1 µg·L−1 in sterilized soil; and a blank with three plant replications at 30, 45, and 60 days after emerging. The maximum quantity of the added PhCs was 100 µg·kg soil−1. A variant of the QuEChERS method was followed to extract PhCs from samples. The limits of quantification were between 10 ng·L−1 and 100 ng·L−1 in extracts. No PhCs over the limits of detection were detected (0.06–0.6 µg·kg−1 of dry plant sample). Hence, the described water reuse methodology poses a negligible consumer risk, which contrasts with hydroponic systems in which this risk has been shown. The results are discussed in terms of the effects of irrigation system, water management and the soil-plant barrier.

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“…The recognized (PSs) or suspected (CECs) impact of these organic micropollutants (OMPs) on the environment and human health have been reported 6 – 8 , in particular when occurring in surface (SW) and drinking water (DW). OMPs are released in effluents from conventional urban and municipal wastewater treatment plants (WWTPs), which are not designed to eliminate these compounds, and from several other activities (e.g., agriculture, livestock and aquaculture), reaching water bodies and courses in a direct way and/or through surface runoff 9 , 10 . Therefore, the broad identification and quantification of PSs and CECs in aquatic compartments are essential to compile the data needed to evolve regulatory frameworks in the field of water policy (e.g., transport and fate in the environment and effects on human and ecological health).…”

Section: Introductionmentioning

confidence: 99%

Carbon xerogels combined with nanotubes as solid-phase extraction sorbent to determine metaflumizone and seven other surface and drinking water micropollutants

Barbosa

Ribeiro

et al. 2021

Sci Rep

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Carbon xerogels (CXs) were synthesized by polycondensation of resorcinol and formaldehyde, followed by thermal annealing, and subjected to hydrothermal oxidation. Solid-phase extraction (SPE) cartridges were filled with CXs and tested for extraction of metaflumizone and other seven environmental micropollutants (acetamiprid, atrazine, isoproturon, methiocarb, carbamazepine, diclofenac, and perfluorooctanesulfonic acid) before chromatographic analysis. The recoveries obtained with the pristine CX were low for most analytes, except for metaflumizone (69 ± 5%). Moreover, it was concluded that the adsorption/desorption process of the micropollutants performed better on CXs with a less acidic surface (i.e., pristine CX). Thus, cartridges were prepared with pristine CX and multi-walled carbon nanotubes (MWCNTs) in a multi-layer configuration. This reusable cartridge was able to simultaneously extract the eight micropollutants and was used to validate an analytical methodology based on SPE followed by ultra-high performance liquid chromatography-tandem mass spectrometry. A widespread occurrence of 6/8 target compounds was observed in surface water collected in rivers supplying three drinking water treatment plants and in the resulting drinking water at the endpoint of each distribution system. Therefore, the first study employing CXs and MWCNTs as sorbent in multi-layer SPE cartridges is herein reported as a proof of concept for determination of multi-class water micropollutants.

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Pharmaceuticals and trace metals in the surface water used for crop irrigation: Risk to health or natural attenuation?

Cited by 56 publications

References 37 publications

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

Soil and Water Management Factors That Affect Plant Uptake of Pharmaceuticals: A Case Study

Carbon xerogels combined with nanotubes as solid-phase extraction sorbent to determine metaflumizone and seven other surface and drinking water micropollutants

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