“…In the last few years, pharmaceuticals as emerging trace contaminants have become a matter of great concern due to their widespread distribution in the aquatic environment (Dhodapkar and Gandhi, 2019;Sangion and Gramatica, 2016), their pseudopersistence and high biological activity (Desbiolles et al, 2018;Fernández et al, 2014b;Verlicchi and Zambello, 2014), and their potential threat to aquatic life and human health (Chavoshani et al, 2020). These compounds enter the aquatic environment from multiple sources, such as municipal sewage, wastewater treatment plants (WWTPs) (Calisto and Esteves, 2009;Felis et al, 2020;Philip et al, 2018;Piram et al, 2008;Silva et al, 2011), effluents from hospitals and the pharmaceutical industry (Cardoso et al, 2014;Oliveira et al, 2015), livestock wastewater (Cycoń et al, 2019), and the utilization of animal manure as a fertilizer in the agriculture sector, animal waste storage, and disposal tanks (FAO & IWMI, 2018).…”