Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds

Razdan, Karan; García‐Lara, Jorge; Sinha, Vivek Ranjan; Singh, Kamalinder K.

doi:10.1016/j.drudis.2022.04.020

Cited by 30 publications

(14 citation statements)

References 85 publications

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“…(iii) Biofilm maturation where microcolonies progressively increase, recruiting more microbial cells, together with the deposition of organic and inorganic solutes. (iv) Detachment of cells that occurs when some cells detach from the biofilm individually or in clusters to colonize new niches [ 16 , 41 ].…”

Section: Infected Woundsmentioning

confidence: 99%

“…Additionally, the infected wound can be considered a chronic inflammatory state that can increase the mortality rate [ 15 ]. Chronic wounds, such as diabetic foot and pressure ulcers, have a greater propensity for the formation of biofilms of pathogenic bacteria since the environment constituted by necrotic tissue and debris allows the attachment of these microorganisms [ 16 ]. In view of this, it is mandatory to understand the cellular basis of wound pathology in order to develop therapeutically viable and cost-effective treatments.…”

Section: Introduction To Wound Healingmentioning

confidence: 99%

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The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

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Despite the fact that skin has a stronger potential to regenerate than other tissues, wounds have become a serious healthcare issue. Much effort has been focused on developing efficient therapeutical approaches, especially biological ones. This paper presents a comprehensive review on the wound healing process, the classification of wounds, and the particular characteristics of each phase of the repair process. We also highlight characteristics of the normal process and those involved in impaired wound healing, specifically in the case of infected wounds. The treatments discussed here include proteins, lipids, and carbohydrates. Proteins are important actors mediating interactions between cells and between them and the extracellular matrix, which are essential interactions for the healing process. Different strategies involving biopolymers, blends, nanotools, and immobilizing systems have been studied against infected wounds. Lipids of animal, mineral, and mainly vegetable origin have been used in the development of topical biocompatible formulations, since their healing, antimicrobial, and anti-inflammatory properties are interesting for wound healing. Vegetable oils, polymeric films, lipid nanoparticles, and lipid-based drug delivery systems have been reported as promising approaches in managing skin wounds. Carbohydrate-based formulations as blends, hydrogels, and nanocomposites, have also been reported as promising healing, antimicrobial, and modulatory agents for wound management.

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Section: Infected Woundsmentioning

confidence: 99%

Section: Introduction To Wound Healingmentioning

confidence: 99%

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

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“…Wounds or skin injuries can provide an excellent habitat for biofilm formation, which can impair the host immune system, exacerbate the patient's condition, and retard the wound closure rate. 57 Therefore, strategies to target the microbial recalcitrant biofilms are essential. In this regard, CYNFs with promising antibiofilm activity could be used as a smart wound dressing material to achieve better clinical outcomes.…”

Section: Storage Stability Analysismentioning

confidence: 99%

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Mishra

Gupta

Srivastava³

et al. 2023

ACS Appl. Bio Mater.

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Wound dressings with outstanding biocompatibility, antimicrobial, and tissue regeneration activities are essential to manage emerging recalcitrant antifungal infections to speed up healing. In this study, we have engineered p-cymene-loaded gellan/PVA nanofibers using electrospinning. Morphological and physicochemical properties of the nanofibers were characterized using a multitude of techniques to validate the successful integration of p-cymene (p-cym). The fabricated nanomaterials exhibited strong antibiofilm activity against Candida albicans and Candida glabrata compared to pure p-cymene. In vitro biocompatibility assay demonstrated that nanofibers did not possess any cytotoxicity to the NIH3T3 cell lines. In vivo, full-thickness excision wound healing study showed that the nanofibers were able to heal skin lesions faster than the conventional clotrimazole gel in 24 days without forming any scar. These findings unraveled p-cymene-loaded gellan gum (GA)/poly(vinyl alcohol) (PVA) nanofibers as an effective biomaterial for cutaneous tissue regeneration.

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“…This helps fight antibiotic resistance. Some antimicrobial nanotherapeutics have the potential to stop biofilms from forming and kill pathogens that live inside cells [ 54 ]. Prominently, nanoparticle surface chemistry is helpful in functionalizing more than one therapeutic agent to target specifically one kind of cell.…”

Section: Nanomedicine-based Advancement In Sepsismentioning

confidence: 99%