Pharmaceutical residues in digested sewage sludge: Occurrence, seasonal variation and risk assessment for soil

Aydın, Senar; Ulvi, Arzu; Bedük, Fatma; Aydın, Mehmet Emin

doi:10.1016/j.scitotenv.2021.152864

Cited by 39 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of antibiotics detected in the present study was generally lower than values reported by other authors. Aydın et al (2022) found ten different antibiotics in WWTP sludge in Turkey, with maximum concentrations detected in the same range that in the current study. In different works carried out in China, the maximum concentration of antibiotic detected in sewage sludge was higher than in our study.…”

Section: Presence Of Antibiotics In Sludge From Wwtpssupporting

confidence: 83%

“…In this regard, Golovko et al (2014) found in water from WWTPs higher concentrations of different antibiotics in winter than in the rest of the year. In the northern hemisphere, antibiotics consumption peaks between January and March (Van Boeckel et al, 2014), which can lead to a total daily pharmaceutical load in the sludge as high as 1 kg day −1 in that season (Aydın et al, 2022). In the current study, the higher presence of antibiotics in spring than in autumn might be due to this seasonal consumption pattern.…”

Section: Presence Of Antibiotics In Sludge From Wwtpsmentioning

confidence: 57%

See 1 more Smart Citation

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

Barreiro¹,

Cela-Dablanca²,

Nebot³

et al. 2022

Span. J. Soil Sci.

View full text Add to dashboard Cite

The huge worldwide use of antibiotics triggers the accumulation of these substances in sludge from wastewater treatment plants (WWTP) and the possible contamination of soils amended with it, as well as of crops growing in these soils. In this work we analyzed the presence of the antibiotics amoxicillin (AMO), cefuroxime (CEF), ciprofloxacin (CIP), clarithromycin (CLA), levofloxacin (LEV), lincomycin (LIN), norfloxacin (NOR), sulfadiazine (SUL), and trimethoprim (TRI), in sludge from different WWTPs in Galicia (NW Spain), as well as in sludge technically treated by waste-managers, in soils where treated sludge was applied, and in crops (corn and vineyard) growing in the amended areas. The antibiotics were quantified by means of high resolution HPLC-mass-chromatography. The results indicate that almost all the sludge samples contained antibiotics, being ciprofloxacin and levofloxacin the most abundant reaching maximum values of 623 and 893 ng/g, respectively. The sludge treatment significantly reduced the number and the concentrations of antibiotics. In 12% of the soil samples where sludge was applied, some antibiotics were detected, but always in small concentrations. Regarding the crops, no antibiotic was detected in the roots, stalk, leaves and grain of corn, neither in grapes sampled in vineyards. It can be concluded that the treatments currently applied in the WWTPs under study are not totally effective in removing antibiotics from the sludge, although the findings of this research suggest that the additional specific treatment of the sludge derived from these WWTPs is effective in reducing the risk of environmental pollution due to a variety of antibiotics, and specifically in the case of soils amended with these organic materials and crops growing on it.

show abstract

Section: Presence Of Antibiotics In Sludge From Wwtpssupporting

confidence: 83%

Section: Presence Of Antibiotics In Sludge From Wwtpsmentioning

confidence: 57%

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

Barreiro¹,

Cela-Dablanca²,

Nebot³

et al. 2022

Span. J. Soil Sci.

View full text Add to dashboard Cite

show abstract

“…In fact, these antibiotics are considered within the group of emerging pollutants. In recent years, these substances have been detected in increasing concentrations in the environment, and it has been facilitated due to their increased use related to comorbidities associated with the COVID-19 pandemic [ 1 ]. According to Ezzariai et al [ 2 ] it can be estimated that the amount of antibiotics used annually worldwide is between 100,000 and 200,000 t.…”

Section: Introductionmentioning

confidence: 99%

“…Between 30 and 90% of the amount of antibiotics ingested by humans is excreted in feces and urine, in their original form or as metabolites [ 1 , 3 ]. In wastewater treatment plants, antibiotics are not completely eliminated, with variate percentage removals, such as 13% in the case of TRI and 87% in the case of fluoroquinolones [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…These emerging pollutants reach the soil after the use of wastewater for irrigation as well as due to the application of sludge as agricultural soil amendments [ 2 ], with both pathways being the main inputs of antibiotics into the environment, along with the application of slurries as soil amendments [ 9 ]. In this sense, in different European countries, including Spain, 50% of the sewage sludge produced is used as an agricultural amendment, since it has high organic matter and nutrient contents, including nitrogen and phosphorus [ 1 , 4 ]. Soils devoted to corn and vineyard production are among those most modified with sludge and manure to increase their fertility, since they are two of the ten most important products derived from agriculture in Spain [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ciprofloxacin and Trimethoprim Adsorption/Desorption in Agricultural Soils

Rodríguez-López

Santás-Miguel

Cela-Dablanca

et al. 2022

IJERPH

View full text Add to dashboard Cite

The current research focuses on the adsorption/desorption characteristics of the antibiotics ciprofloxacin (CIP) and trimethoprim (TRI) taking place in 17 agricultural soils, which are studied by means of batch-type experiments. The results show that adsorption was higher for CIP, with Freundlich KF values ranging between 1150 and 5086 Ln µmol1−n kg−1, while they were between 29 and 110 Ln µmol1−n kg−1 in the case of TRI. Other parameters, such as the Langmuir maximum adsorption capacity (qm(ads)), as well as the Kd parameter in the linear model and also the adsorption percentages, follow the same trend as KF. Desorption was lower for CIP (with KF(des) values in the range 1089–6234 Ln µmol1−n kg−1) than for TRI (with KF(des) ranging between 26 and 138 Ln µmol1−n kg−1). The higher irreversibility of CIP adsorption was also confirmed by its lower nF(des)/nF(ads) ratios, compared to TRI. Regarding soil characteristics, it was evidenced that nitrogen and carbon contents, as well as mineral fractions, had the highest influence on the adsorption/desorption process. These results can be considered relevant as regards the fate of both antibiotics when they reach the environment as pollutants and therefore could be considered in assessment procedures focused on environmental and public health aspects.

show abstract

Multiresidue method for the determination of critically and highly important classes of antibiotics and their metabolites in agricultural soils and sewage sludge

Mejías,

Santos,

Martín

et al. 2023

Anal Bioanal Chem

View full text Add to dashboard Cite

In this paper, a method is proposed for the determination of antibiotics classified by the World Health Organization as critically important (four macrolides and three quinolones) and highly important (one tetracycline, one diaminopyridine, and three sulfonamides) and eight of their metabolites. The method is based on ultrasound-assisted extraction, dispersive solid-phase extraction clean-up, and analytical determination by liquid chromatography–tandem mass spectrometry. Variables affecting each stage of the analytical method were thoroughly optimised. The method was validated for its application to sewage sludge from different treatment stages (non-treated sludge: primary and secondary sludge; and treated sludge: digested sludge and compost) and to agricultural soil. Limits of quantification were in the range of 0.03–7.50 ng g−1 dry weight (dw) for most of the compounds. Accuracy values were in the range of 70–102%. Precision was below 17%. The application of the method to real samples revealed that macrolides and fluoroquinolones were the antibiotic classes at the highest concentrations in all types of samples. The lowest concentrations of antibiotics were measured in compost (highest concentration: 27 ng g−1 dw, corresponding to norfloxacin) and soil samples (highest concentration: 93 ng g−1 dw, corresponding to a metabolite of clarithromycin). The proposed method is the first developed to date for the determination of multiclass antibiotics and their main metabolites in sludge from different treatment stages. The method can provide a useful tool for obtaining information about antibiotics in sewage sludge prior to its application to agricultural soils and in agricultural soils. Graphical Abstract

show abstract

Pharmaceutical residues in digested sewage sludge: Occurrence, seasonal variation and risk assessment for soil

Cited by 39 publications

References 43 publications

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

Ciprofloxacin and Trimethoprim Adsorption/Desorption in Agricultural Soils

Multiresidue method for the determination of critically and highly important classes of antibiotics and their metabolites in agricultural soils and sewage sludge

Contact Info

Product

Resources

About