Pharmaceutical perspective on bioactives from Alstonia scholaris: ethnomedicinal knowledge, phytochemistry, clinical status, patent space, and future directions

Pandey, Komal; Shevkar, Chaitrali; Bairwa, Khemraj; Kate, Abhijeet S.

doi:10.1007/s11101-020-09662-z

Cited by 30 publications

(15 citation statements)

References 154 publications

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“…is locally known as Sitaona in Bodo and blackboard or devil's tree in English (13). It belongs to the family Apocynaceae, an evergreen tree native to southern China, tropical Asia and Australasia (14). Though A. scholaris bark is reported to be toxic at a higher dose (15), yet, it is found to be used in the treatment of myriad diseases (16).…”

Section: Plant Materialsmentioning

confidence: 99%

“…Though A. scholaris bark is reported to be toxic at a higher dose (15), yet, it is found to be used in the treatment of myriad diseases (16). It is also reportedly used for medicinal purposes for the treatment of various diseases such as dysentery, diarrhoea, fever and other stomach aches (17), hepatoprotective (18), malaria, jaundice, gastrointestinal troubles and cancer (13).…”

Section: Plant Materialsmentioning

confidence: 99%

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Characterisation of indigenous plants for herbal formulations preparation based on pharmacognostic and physiochemical data

et al. 2022

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The use of plant-based drugs has increased considerably in the modern world for their efficiency in managing diseases with lesser side effects than synthetic drugs. The current study was aimed to confirm the identity, quality and purity of some locally available potential medicinal plants such as Alstonia scholaris (bark), Centella asiatica (whole plant), Drymaria cordata (whole plant), Hydrocotyle sibthorpioides (whole plant), Oroxylum indicum (bark), Senna hirsuta (leaf), Senna occidentalis (leaf), Solanum indicum (root), Stephania japonica (tuber) in powdered form. The powdered plant parts were evaluated for preliminary phytochemicals, pharmacognostical studies, physical characteristics and heavy metals. Preliminary phytochemical screening of the different extracts inferred the existence of carbohydrates, phenolics, alkaloids and amino acids while triterpenoids were absent. Microscopical study of the powder revealed the diagnostic qualities such as stone cells, trichomes, stomata, calcium oxalate crystal, fibres, xylem vessel, pitted spiral vessels, etc. The colour, odour, flavour/taste and texture of the pulverized plant were overall acceptable. The physical characteristics which determine the flow rate of the powder with respect to Carr’s index and Hausner’s ratio were found to be good to passable except for Hydrocotyle sibthorpioides (whole plant), Oroxylum indicum (bark), which were not easily passable. The heavy metal test showed the absence of bismuth, cadmium and lead. Thus the present study may serve as a standard reference for the quality control analysis of the herbal drug either singly or in synergy.

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Section: Plant Materialsmentioning

confidence: 99%

Section: Plant Materialsmentioning

confidence: 99%

Characterisation of indigenous plants for herbal formulations preparation based on pharmacognostic and physiochemical data

et al. 2022

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“…Some of the important results of such pharmacological studies are summarized in table 3. Nearly 169 alkaloids have been reported, along with iridoids, coumarins, flavonoids, and steroids from this plant (Pandey et al 2020). Several pharmacologically active compounds such as alstonine, echitamine chloride, villalstonine, lupeol acetate, scholaricine, etc.…”

Section: Alstonia Scholaris In Ethnomedicinal Traditionmentioning

confidence: 99%

“…have been isolated from this plant (Arulmozhi et al 2007). Strictamine isolated from this plant has shown antiviral activity equivalent to that of acyclovir (Pandey et al 2020).…”

Section: Alstonia Scholaris In Ethnomedicinal Traditionmentioning

confidence: 99%

Alstonia scholaris in the ethnomedicinal and religious tradition of Coastal Karnataka, India

Bhandary¹

2020

Biodiversitas

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Abstract. MJ Bhandary. 2020. Alstonia scholaris in the ethnomedicinal and religious tradition of Coastal Karnataka, India. Biodiversitas 21: 1569-1577. The tribal and non-tribal indigenous communities of coastal districts of Karnataka use Alstonia scholaris (L.) R. Br. for the treatment of various ailments such as fever, asthma, leucorrhea, eczema, indigestion and also to heal spider bites. An annual health-related ritual of mass drinking of a bitter juice or decoction of the stem bark of this tree on the new moon (amavasya) day of ‘aati’ month of the traditional ‘tulu’ calendar coinciding with the rainy monsoon season is popularly followed in the study area, especially by the rural families. The underlying belief is that this drink keeps away all ailments and ensures wellbeing. The recorded ethnomedicinal uses and the traditional practice of mass drinking of the bitter juice appear to be scientifically meaningful when interpreted on the background of the ayurvedic uses and the wide range of curative properties ascribed to this plant, many of which have been confirmed by reported pharmaco-chemical studies. Studies have also indicated that the toxicity of the bark extract was minimum during monsoon season and the concentration of active principle was maximum in the bark juice collected on the particular new moon day. This further justifies the timing of the described annual medicine drinking event. In addition, some Tulu language-speaking indigenous communities consider this tree as the reincarnation of a mythological demon called Bali and worship its branch during the festival days of Deepavali, in honor of him. Thus, A. scholaris emerges as a plant of great ethnobotanical significance in the study area.

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“…Alstonia scholaris , historically used in “Dai” ethnopharmacology in China, is well known for its ability to produce pentacyclic triterpenes and alkaloids . The defined mixture of alkaloids from A. scholaris has been registered as an investigational new botanical drug (no.…”

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confidence: 99%

Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

Zhao

Xiong

et al. 2021

Org. Lett.

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Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo.

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Pharmaceutical perspective on bioactives from Alstonia scholaris: ethnomedicinal knowledge, phytochemistry, clinical status, patent space, and future directions

Cited by 30 publications

References 154 publications

Characterisation of indigenous plants for herbal formulations preparation based on pharmacognostic and physiochemical data

Characterisation of indigenous plants for herbal formulations preparation based on pharmacognostic and physiochemical data

Alstonia scholaris in the ethnomedicinal and religious tradition of Coastal Karnataka, India

Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

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