Pharmaceutical Options for Stress Urinary Incontinence

Juneau, Andrea D.; Gomelsky, Alex

doi:10.1007/s11884-019-00537-4

Cited by 2 publications

(2 citation statements)

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“…Ефективність дулоксетину була показана при лікуванні жінок із гіперактивним сечовим міхуром [31,35,47] Було зроблено висновок, що використання дулоксетину у поєднані з електростимуляцію шийки сечового міхура та вправами для зміцнення м'язів тазового дна покращує результати лікування жінок із СНС, а тому за відсутності протипоказань до електростимуляції таке поєднане лікування потрібно застосовувати з метою покращення якості життя пацієнток, уникнення хірургічного втручання та відбору хворих для операції.…”

Section: место дулоксетина в консервативной терапии стрессового недержания мочи у женщин и мужчин ви горовой ве литвинецею гурженкоunclassified

Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence

Gorovyi

Литвинець

Gurzhenko

2021

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History of introduction of duloxetine in medical practice, mechanism of action and using of duloxetine in concervative treatment women and men with stress urinary incontinence are shown. Modern structure of external urethral sphincter in women and men was shown with increasing of sphincter tone under duloxetine influence. Duloxetine recommended by International Continent Society for initial treatment women with stress urinary incontinence but this drug gives only improvement of urine continence and quality of life with side effects. Duloxetine with connection with pelvic floor muscle training gives better results than using separately duloxetine and pelvic floor muscle training. Nausuea is the most frequency side symptom after using duloxetine. Results of own investigations were shown and indications for using duloxetine in women with stress urinary incontinence were summed up. The most positive results were obtained after combination of duloxetine with pelvic floor muscle training and electrostimulation of urethral sphincter. Duloxetine for treatment men with stress urinary incontinence after radical prostatectomy is only clinical tested. Estimation of efficacy of duloxetine in treatment men with stress urinary incontinence after open prostatectomy due to benign prostatic hyperplasia is needed.

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Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence

Gorovyi

Литвинець

Gurzhenko

2021

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“…[ 13 ] Pharmaceutical approaches, such as alpha-adrenergic agonist, hormone replacement treatment, are available drug therapies for urinary incontinence. [ 14 ] However, the insufficient efficacy and significant side effects limit the wide use of these pharmaceutical approaches. Therefore, conservative interventions have become the first-line option for managing women with PPUI.…”

Section: Introductionmentioning

confidence: 99%

A network meta-analysis protocol of conservative interventions for urinary incontinence in postpartum women

Wang

et al. 2020

Medicine

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Background: Postpartum urinary incontinence (PPUI) is a common urological condition in women after childbirth. Due to the side effects of surgical and pharmacological therapies, the patients and physicians alike express a strong preference for conservative approaches on PPUI, such as pelvic floor muscle training, biofeedback, electrical stimulation, bladder training, vaginal cones and acupuncture. Application of these conservative approaches should be guided by high quality evidence, yet their comparative effectiveness has not been well documented. Therefore, the network meta-analysis aims to compare, rank and summarize all available studies to determine which conservative intervention is more effective for PPUI. Methods: In this present study, qualified English and Chinese studies will be searched in PubMed, Scopus, EMBASE, The Cochrane Library, Web of Science, VIP Database, Wanfang Database, Chinese Biomedical Literature Database and China National Knowledge Infrastructure. All eligible randomized controlled trails (RCTs) of conservative interventions for PPUI will be included. R software 3.61 (R Foundation for Statistical Computing, Vienna, Austria) will be applied to synthesize data and conduct network meta-analysis. I 2 statistic and Z test will be used to assess heterogeneity and inconsistency, respectively. Results: Ethical approval is not required for this existed literature based meta-analysis. The findings of this research will be disseminated through a recognized journal. Conclusion: The findings of this study will provide ranking evidence for clinicians and patients to choose a more appropriate conservative therapy on PPUI. Trial registration number: PROSPERO CRD42020168042

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Pharmaceutical Options for Stress Urinary Incontinence

Cited by 2 publications

References 50 publications

Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence

Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence

A network meta-analysis protocol of conservative interventions for urinary incontinence in postpartum women

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