Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria

Roque‐Borda, Cesar Augusto; Silva, Patrícia Bento da; Rodrigues, Mosar Corrêa; Filippo, Leonardo Delello Di; Duarte, Jonatas Lobato; Chorilli, Marlus; Vicente, Eduardo Festozo; Garrido, Saulo Santesso; Pavan, Fernando Rogério

doi:10.1016/j.ejmech.2022.114640

Cited by 27 publications

(19 citation statements)

References 225 publications

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“…[ 139 ] Compared with single peptides, AMPs that incorporate biomaterials achieve slow release, provide effective local concentrations, reduce off‐target effects and toxicity, improve the stability and activity of the AMPs, and modulate the efficacy of the local microenvironment. [ 140 ] Additionally, advances in biomaterials engineering will further allow the co‐administration of different classes of antimicrobial agents to maximize therapeutic indices and minimize the development of resistance and other adverse effects. [ 141 ]…”

Section: Discussionmentioning

confidence: 99%

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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Owing to the increase in multidrug-resistant bacterial isolates in hospitals globally and the lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have increased substantially. There is thus an urgent need to develop new antimicrobial drugs and their related formulations. In recent years, natural antimicrobial peptides (AMPs), AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery of AMPs have shown great potential in the treatment of bacterial infections. In this review, it is focused on the development prospects and shortcomings of various AMP-based biomaterials for treating animal model infections, such as abdominal, skin, and eye infections. It is hoped that this review will inspire further innovations in the design of AMP-based biomaterials for the treatment of bacterial infections and accelerate their commercialization.

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Section: Discussionmentioning

confidence: 99%

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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“…Simple substitution can bring changes in functional and structural properties because this class of peptides have a very short length. For an instance, if we replace Pro residue with Ala in the tritpticin then the peptide structure will be transformed into α helical conformation that has higher cytotoxicity and improved activity against antimicrobial agents [39]. Biofilm and antibacterial peptides Antibacterial peptides' activity against biofilm is less studied as compared to the study of these peptides against microorganisms.…”

Section: Structural Classification Of Antibacterial Peptidesmentioning

confidence: 99%

A review on the potential of antibacterial peptides to control biofilm resistance

Liaqat¹

2023

PAB

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Biofilms are comprised of communities of bacteria that are encased in the matrix. In biofilm, microbes become dormant and less sensitive to ordinary antibiotics. It is difficult for the antibiotics to penetrate and reach the depth of biofilm. These characteristics of biofilm make it 1000 times more resistant than planktonic microbes. Antibacterial peptides are used as an alternative of antibiotics to deal with the infections that are related to biofilm. Antibacterial peptides are small peptides that have broad action against Gram-positive and Gram-negative bacteria. Significant mechanisms of antibacterial peptides are: 1) degradation or disruption of the membrane potential of biofilms' embedded cell, 2) interruption of bacterial cells' signaling system, 3) degradation of polysaccharides and matrix of biofilm, 4) inhibition of the bacterial alarmone to avoid the stringent responses and 5) down-regulation of the genes that are responsible for biofilm formation and transportation of the binding proteins. The main purpose of this review article is to summarize the fresh material related to antibacterial peptides, their activity, and mechanism of action against the biofilm. Furthermore, health community and society can get new information regarding the suitable alternatives of ordinary antibiotics to control resistance in biofilms.

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“…These molecules are constituents of the defense systems of several organisms, are widely distributed in nature, and act against various pathogens, including bacteria, fungi, Leishmania , and viruses [ 3 , 4 ]. AMPs are promising novel antibiotics that kill multidrug-resistant bacteria and show activity against some bacteria that are considered a priority by the WHO [ 5 ]. Their sequence normally has from 10 to 50 amino acids and is modulated by structure–function relationships [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein

et al. 2023

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Recent studies have shown that the peptide [des-Cys11,Lys12,Lys13-(p-BthTX-I)2K] (p-Bth) is a p-BthTX-I analog that shows enhanced antimicrobial activity, stability and hemolytic activity, and is easy to obtain compared to the wild-type sequence. This molecule also inhibits SARS-CoV-2 viral infection in Vero cells, acting on SARS-CoV-2 PLpro enzymatic activity. Thus, the present study aimed to assess the effects of structural modifications to p-Bth, such as dimerization, dendrimerization and chirality, on the antibacterial activity and inhibitory properties of PLpro. The results showed that the dimerization or dendrimerization of p-Bth was essential for antibacterial activity, as the monomeric structure led to a total loss of, or significant reduction in, bacterial activities. The dimers and tetramers obtained using branched lysine proved to be prominent compounds with antibacterial activity against Gram-positive and Gram-negative bacteria. In addition, hemolysis rates were below 10% at the corresponding concentrations. Conversely, the inhibitory activity of the PLpro of SARS-CoV-2 was similar in the monomeric, dimeric and tetrameric forms of p-Bth. Our findings indicate the importance of the dimerization and dendrimerization of this important class of antimicrobial peptides, which shows great potential for antimicrobial and antiviral drug-discovery campaigns.

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Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria

Cited by 27 publications

References 225 publications

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

A review on the potential of antibacterial peptides to control biofilm resistance

Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein

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